2 Results for "

perivascular pathways

" in MedChemExpress (MCE) Product Catalog:
Products (2)

2 Results for "perivascular pathways" in MCE Product Catalog:

Pegevongitide
Pegevongitide
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Cat. No.: HY-P10887
CAS No.: 2988012-71-9
Synonyms: AV-001
Target:  

Tie ANGPTL SARS-CoV Aquaporin TNF Receptor PAI-1 CXCR P-selectin

Research Areas:  

Cardiovascular Disease Infection Neurological Disease

Pegevongitide (AV-001) is a Tie2 agonist. Pegevongitide resists the increased endothelial cell permeability induced by SARS-CoV-2 infection. Pegevongitide activates the angiogenin (angiogenin)/Tie2 signaling pathway. Pegevongitide reduces perivascular space dilation and upregulates perivascular Aquaporin-4 expression. Pegevongitide decreases the expression of TNF-α, PAI-1, CXCL9 and P-selectin, improves white matter integrity, enhances cognitive function and exerts neuroprotective effects. Pegevongitide improves white matter integrity in middle-aged rats with vascular dementia induced by multiple microinfarctions . Pegevongitide can be used in related research on diseases such as COVID-19 and vascular dementia .
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(S,S)-Formoterol
(S,S)-Formoterol
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Cat. No.: HY-B0010C
CAS No.: 67346-48-9
Synonyms: (+)-Formoterol
Target:  

Interleukin Related Adrenergic Receptor IFNAR

Research Areas:  

Inflammation/Immunology

(S,S)-Formoterol ((+)-Formoterol) is the (S,S)-enantiomer of Formoterol (HY-B0010B). (S,S)-Formoterol is a β2-adrenergic receptor (β2-adrenergic receptor) ligand. (S,S)-Formoterol can induce mast cell mediator release, peribronchial and perivascular inflammatory cell infiltration, basal airway tone, IFN-γ production, and IL-4 production. (S,S)-Formoterol acts through the β2-adrenergic receptor, altering its transduction pathways and modulating receptor structure and function. (S,S)-Formoterol can be used in the study of asthma .
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