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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
58 Results for "
phosphatidylinositol 3-kinase
" in MedChemExpress (MCE) Product Catalog:
Products (58)
58 Results for "phosphatidylinositol 3-kinase" in MCE Product Catalog:
1221
1221 Publications Verification
Target:
Research Areas:
LY294002 hydrochloride is a potent and broad-spectrum PI3K inhibitor, with IC50 values of 0.5, 0.57, and 0.97 μM for P110α, P110δ and P110β, respectively. LY294002 hydrochloride also inhibits CK2 with an IC50 of 98 nM. LY294002 hydrochloride can be used for pancreatic cancer research .
8
8 Cited Publications
Cat. No.: HY-P80846
Synonyms: PIK3R1; GRB1; phosphatidylinositol 3-kinase regulatory subunit alpha; PI3-kinase regulatory subunit alpha; PI3K regulatory subunit alpha; PtdIns-3-kinase regulatory subunit alpha; phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha; PI3-kinase s
7
7 Cited Publications
Cat. No.: HY-P81211
Synonyms: PI3-kinase p110 subunit beta; p-PI3Kβ(Ser1070); PI 3-kinase C2β; p110 BETA; p110Beta; phosphatidylinositol 3 kinase catalytic beta polypeptide; phosphatidylinositol 4 5 bisphosphate 3 kinase 110 kDa catalytic subunit beta; phosphatidylinositol 4 5 bisphosphate 3 kinase catalytic subunit beta isoform; phosphatidylinositol-4; Phosphoinositide 3 kinase catalytic beta polypeptide; PI3 kinase p110 subunit beta; PI3-kinase subunit beta; PI3K; PI3K beta; PI3K-beta; PI3Kbeta; PI3KCB; PIK3C1; Pik3cb; PK3CB_HUMAN; PtdIns 3 kinase p110; PtdIns-3-kinase subunit beta; PtdIns-3-kinase subunit p110-beta; 5-bisphosphate 3-kinase 110 kDa catalytic subunit beta; 5-bisphosphate 3-kinase catalytic subunit beta isoform.
4
Category:
Alkaloids Rutaceae Quinoline Alkaloids Plants Skimmia reevesiana Fort. Disease Research Fields Inflammation/Immunology
Target:
4
4 Cited Publications
Cat. No.: HY-P80867
Synonyms: PIK3R1; GRB1; phosphatidylinositol 3-kinase regulatory subunit alpha; PI3-kinase regulatory subunit alpha; PI3K regulatory subunit alpha; PtdIns-3-kinase regulatory subunit alpha; phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha; PI3-kinase s
1
1 Cited Publications
Cat. No.: HY-P1116
CAS No.: 794466-43-6
Research Areas:
1
1 Cited Publications
Cat. No.: HY-P703580
Purity: ≥ 85%, as determined by reducing SDS-PAGE.
Synonyms: PIK3CA; phosphatidylinositol-4,5-Bisphosphate 3-kinase; phosphatidylinositol-4,5-Bisphosphate 3-kinase Catalytic Subunit Alpha; PI3-kinase P110 Subunit Alpha; phosphatidylinositol 4,5-Bisphosphate 3-kinase Catalytic Subunit Alpha Isoform; PtdIns-3-kinase
Species:
Human
Source:
Sf9 insect cells
1
1 Cited Publications
Cat. No.: HY-P701744
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: PIK3R3; PI3-kinase Regulatory Subunit Gamma; Phosphoinositide-3-kinase Regulatory Subunit 3; PI3K Regulatory Subunit Gamma; phosphatidylinositol 3-kinase 55 KDa Regulatory Subunit Gamma; PI3-kinase Subunit P55-Gamma; phosphatidylinositol 3-kinase Regulato
Species:
Human
Source:
Sf9 insect cells
Synonyms: ME-401; PWT-143
Zandelisib (ME-401) is a selective, orally active, non-covalent inhibitor of PI3Kδ. Zandelisib can sustainably inhibit AKT phosphorylation and downstream signaling pathways. Zandelisib can be used in the study of malignancies such as relapsed/refractory B-cell lymphoma .
Vulolisib is a potent and orally active phosphatidylinositol 3-kinase (PI3K) inhibitor, with IC50 values of 0.2 nM, 168 nM, 90 nM and 49 nM for PI3Kα, PI3Kβ, PI3Kγ and PI3Kδ, respectively. Antiproliferative and antineoplastic activity .
Cat. No.: HY-P10323
Synonyms: Tumstatin (74-98), human
Cat. No.: HY-P10323A
Synonyms: Tumstatin (74-98), human TFA
Cat. No.: HY-W049881
CAS No.: 2521-07-5
Target:
Research Areas:
9-Methyl-β-carboline is a monoamine oxidase inhibitor and dopaminergic modulator, with an IC50 of 1 μM against human MAO-A and an IC50 of 15.5 μM against human MAO-B. 9-Methyl-β-carboline possesses cognitive enhancement potential and can cross the blood-brain barrier. 9-Methyl-β-carboline increases dopamine levels by inhibiting monoamine oxidase activity and microglial proliferation. 9-Methyl-β-carboline activates PKA/PKC and mitochondrial respiratory chain complex I, promotes neurotrophic factor expression and reduces α-synuclein (α-synuclein) levels, thereby reversing neurotoxin-induced dopaminergic neuron damage. 9-Methyl-β-carboline also regulates the PI3K pathway and exerts an anti-proliferative effect on astrocytes. 9-Methyl-β-carboline is widely used in Parkinson's disease-related studies .
Cat. No.: HY-109029
CAS No.: 1262440-25-4
Synonyms: INCB040093
Dezapelisib (NCB040093) is a potent inhibitor of phosphatidylinositol 3-kinase δ (PI3Kδ). Dezapelisib is a promising research strategy for select R/R B-cell lymphomas .
Cat. No.: HY-P991842
Target:
Research Areas:
Cat. No.: HY-116497
CAS No.: 1627843-95-1
PH11 is a novel focal adhesion kinase (FAK) inhibitor that rapidly induces apoptosis in TRAIL-resistant PANC-1 cells when combined with TRAIL, but has no effect on normal human fibroblasts. The study found that PH11 downregulates c-FLIP through inhibition of FAK and phosphatidylinositol-3-kinase (PI3K)/AKT pathways, thereby restoring the TRAIL apoptotic pathway, suggesting that this combination therapy may provide an attractive therapeutic strategy for the safe and effective treatment of pancreatic cancer. PH11 selectively inhibits c-FLIP expression by modulating upstream signaling pathways and may represent an innovative therapeutic strategy. Although further work is needed to fully elucidate the mechanism of PH11-induced TRAIL sensitization, we believe that our results will provide a new approach to target c-FLIP without the risk of interfering with caspase-8 processing, which could potentially lead to TRAIL resistance. This study also suggests a role for the FAK/AKT signaling pathway in regulating c-FLIP expression in TRAIL-induced apoptosis, and this understanding will provide important clues to control the resistance mechanism to optimize the potential of TRAIL-based pancreatic cancer treatment.
Cat. No.: HY-135526
CAS No.: 56617-66-4
Synonyms: Desmethoxyviridiol
Demethoxyviridiol is a mycotoxin originally isolated from N. hinnuleum. Demethoxyviridiol induces lethality in day-old cockerels (LD50=4.2 mg/kg). Demethoxyviridiol is also an inhibitor of phosphatidylinositol 3-kinase (PI3K).
Cat. No.: HY-17651
CAS No.: 2504036-13-7
Target:
Research Areas:
PI3K-IN-60 (Compound 34) is a highly selective phosphatidylinositol 3-kinase gamma (PI3Kγ) inhibitor. PI3K-IN-60 is promising for research of autoimmune diseases (e.g., multiple sclerosis) and cancers (e.g., breast cancer, pancreatic ductal adenocarcinoma) .
Cat. No.: HY-171558
CAS No.: 2633645-58-4
PI3K-IN-56 (Compound 1) is an orally active, potent and selective irreversible inhibitor of phosphoinositide 3-kinase (PI3K). PI3K-IN-56 irreversibly blocks the phosphatidylinositol-3,4,5-triphosphate (PIP3) production and downstream AKT signaling pathway. PI3K-IN-56 is promising for research of PI3Kα-driven cancers, such as breast and ovarian cancers .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
