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phosphoenolpyruvate carboxykinase

" in MedChemExpress (MCE) Product Catalog:

標的別:	PEPCK (1) Endogenous Metabolite (1) GABA Receptor (1) Glucocorticoid Receptor (1) Histone Demethylase (1) Monoamine Oxidase (1) PKC (1)
研究分野別:	Cancer (1) Cardiovascular Disease (1) Inflammation/Immunology (2) Metabolic Disease (2) Neurological Disease (1)

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Targets Recommended: PEPCK

製品番号	製品名	Target	研究分野	構造式

HY-128923

SKF-34288 hydrochloride 5+ Cited Publications 3-Mercaptopicolinic acid hydrochloride; 3-MPA hydrochloride	PEPCK	Metabolic Disease
SKF-34288 (3-Mercaptopicolinic acid) hydrochloride is an orally active phosphoenolpyruvate carboxykinase (PEPCK) inhibitor (K_i: 2-9 μM). SKF-34288 hydrochloride is a potent hypoglycemic agent by inhibiting glucose synthesis. SKF-34288 hydrochloride also inhibits Asn metabolism and increases amino acids and amides .

HY-113422

Tetrahydrocorticosterone	Endogenous Metabolite Glucocorticoid Receptor	Inflammation/Immunology
Tetrahydrocorticosterone is a glucocorticoid. One of its active forms, 5α-Tetrahydrocorticosterone (HY-113364), exerts its effects by binding to the GC receptor and inhibiting inflammatory processes. Tetrahydrocorticosterone is naturally synthesized by the adrenal glands and plays a key role in regulating the metabolism of carbohydrates, proteins and fats .

HY-B1018A

Phenelzine sulfate 5+ Cited Publications	Monoamine Oxidase GABA Receptor Histone Demethylase	Cardiovascular Disease Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
Phenelzine sulfate, an antidepressant agent, is an irreversible and orally active monoamine oxidase (MAO-A and MAO-B) inhibitor. Phenelzine sulfate inhibits GABA transaminase and primary amine oxidase (PrAO), and sequester reactive aldehydes. Phenelzine sulfate also inhibits LSD1 (Ki: 5.6 μM) and suppresses oxidative stress and lipogenesis. Phenelzine sulfate elevates neurotransmitters (serotonin, norepinephrine, dopamine). Phenelzine sulfate is studied in neurological, metabolic and cancer diseases for depression and anxiety disorders, stroke, spinal cord injury, traumatic brain injury, multiple sclerosis, Parkinson’s disease, Alzheimer’s disease, inflammatory pain, obesity and prostate cancer .

HY-N13191

Ingenol 3-monobenzoate Ingenol 3-benzoate	PKC	Others
Ingenol 3-monobenzoate (Ingenol 3-benzoate) is a disgust inducing agent. Ingenol 3-monobenzoate can bind to and activate PKC (K_i=0.14 nM), inhibit the gene expression of phosphoenolpyruvate carboxykinase, thereby inhibiting gluconeogenesis, and increasing blood cortisol levels, producing food aversion .

Tetrahydrocorticosterone	Structural Classification Endogenous metabolite Steroids Source Classification	Endogenous Metabolite Glucocorticoid Receptor
Tetrahydrocorticosterone is a glucocorticoid. One of its active forms, 5α-Tetrahydrocorticosterone (HY-113364), exerts its effects by binding to the GC receptor and inhibiting inflammatory processes. Tetrahydrocorticosterone is naturally synthesized by the adrenal glands and plays a key role in regulating the metabolism of carbohydrates, proteins and fats .

Ingenol 3-monobenzoate Ingenol 3-benzoate	天然物 Euphorbia esula L. Euphorbiaceae Plants Source Classification	PKC
Ingenol 3-monobenzoate (Ingenol 3-benzoate) is a disgust inducing agent. Ingenol 3-monobenzoate can bind to and activate PKC (K_i=0.14 nM), inhibit the gene expression of phosphoenolpyruvate carboxykinase, thereby inhibiting gluconeogenesis, and increasing blood cortisol levels, producing food aversion .

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HY-P75957

	PCK2 Protein, Human (sf9, His-GST) phosphoenolpyruvate carboxykinase [GTP], mitochondrial; PEPCK-M; PCK2; PEPCK2	Human	Sf9 insect cells
	As a key enzyme in cellular metabolism, PCK2 protein catalyzes the conversion of oxaloacetate (OAA) into phosphoenolpyruvate (PEP), representing the rate-limiting step in the metabolic pathway and responsible for the production of glucose from other precursors derived from lactate and citric acid cycle. PCK2 Protein, Human (sf9, His-GST) is the recombinant human-derived PCK2 protein, expressed by Sf9 insect cells , with C-His, N-GST labeled tag.

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Host:	Mouse (1) Rabbit (2)
Reactivity:	Human (3) Bovine (1) Rat (3) Mouse (3) Dog (1) Pig (1)
Application:	IHC-P (2) ICC/IF (2) IHC-F (2) WB (3)
Isotype:	IgG (2)
Conjugation:	Non-conjugated (3)
Clonality:	Monoclonal (2) Recombinant (1)
Modification:	Unmodified (2)

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HY-P81802

	PCK2 Antibody (YA1547) PCK2; PEPCK2; phosphoenolpyruvate carboxykinase [GTP]; mitochondrial; PEPCK-M; phosphoenolpyruvate carboxylase	WB, IHC-F, IHC-P, ICC/IF	Human, Mouse, Rat
	PCK2 Antibody (YA1547) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to PCK2.

HY-P85451

	PCK2 Antibody (YA5143) PCK2; PEPCK2; phosphoenolpyruvate carboxykinase [GTP]; mitochondrial; PEPCK-M; phosphoenolpyruvate carboxylase	WB	Human, Mouse, Rat, Bovine, Dog, Pig
	PCK2 Antibody (YA5143) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to PCK2.

HY-P81802A

	PCK2 Antibody (YA1547)(PBS only) PCK2; PEPCK2; phosphoenolpyruvate carboxykinase [GTP]; mitochondrial; PEPCK-M; phosphoenolpyruvate carboxylase	WB, IHC-F, IHC-P, ICC/IF	Human, Mouse, Rat
	PCK2 Antibody (YA1547) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to PCK2.

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BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.

BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

MedchemExpress Validation 03

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred

MedchemExpress Validation 04

MedchemExpress Validation

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