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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
47 Results for "
platelet P2Y12 receptor
" in MedChemExpress (MCE) Product Catalog:
Products (47)
47 Results for "platelet P2Y12 receptor" in MCE Product Catalog:
33
33 Publications Verification
Synonyms: Clopidogrelum
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Clopidogrel is an orally active platelet inhibitor that targets P2Y12 receptor. Clopidogrel is used to inhibit blood clots in coronary artery disease, peripheral vascular disease, and cerebrovascular disease.
13
13 Cited Publications
Synonyms: AZD6140; AR-C 126532XX
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Ticagrelor (AZD6140) is a reversible oral P2Y12 receptor antagonist for the treatment of platelet aggregation.
1
1 Cited Publications
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PSB-0739 is a high-affinity potent, competitive, nonselective platelet P2Y12 receptor antagonist with a Ki values of 24.9 nM. The P2Y12 receptor plays a crucial role in platelet aggregation. Antithrombotic effect .
1
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Prasugrel (PCR 4099), a thienopyridine and proagent, inhibits platelet function. Prasugrel is an orally active and potent P2Y12 receptor antagonist, and inhibits ADP-induced platelet aggregation .
1
1 Cited Publications
Synonyms: PCR 4099 hydrochloride
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Prasugrel hydrochloride (PCR 4099 hydrochloride), a thienopyridine and proagent, inhibits platelet function. Prasugrel hydrochloride is an orally active and potent P2Y12 receptor antagonist, and inhibits ADP-induced platelet aggregation .
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N6-(4-Hydroxybenzyl) adenosine (Para-topolin riboside) is an equilibrative nucleoside transporter 1 (ENT1) inhibitor and a selective agonist of adenosine A2a receptor (A2aR), and also exhibits activity against P2Y12 receptor. N6-(4-Hydroxybenzyl) adenosine reduces ethanol intake and preference, attenuates operant conditioning-induced ethanol place preference, decreases the value of ethanol-related rewards, and inhibits collagen-induced platelet aggregation. N6-(4-Hydroxybenzyl) adenosine can be used in studies related to alcohol use disorder .
1
1 Cited Publications
Cat. No.: HY-N0910
CAS No.: 155683-00-4
1
1 Cited Publications
Cat. No.: HY-10064S
CAS No.: 1265911-55-4
1
1 Cited Publications
Cat. No.: HY-P87002
Synonyms: ADP glucose receptor antibody; ADP-glucose receptor antibody; ADPG R antibody; ADPG-R antibody; ADPGR antibody; BDPLT8 antibody; G protein coupled receptor SP1999 antibody; Gi coupled ADP receptor HORK 3 antibody; Gi coupled ADP receptor HORK3 antibody; HORK 3 antibody; ADP glucose receptor antibody; ADP-glucose receptor antibody; ADPG R antibody; ADPG-R antibody; ADPGR antibody; BDPLT8 antibody; G protein coupled receptor SP1999 antibody; Gi coupled ADP receptor HORK 3 antibody; Gi coupled ADP receptor HORK3 antibody; HORK 3 antibody; HORK3 antibody; P2RY 12 antibody; P2RY12 antibody; P2T(AC) antibody; P2Y 12 antibody; P2Y purinoceptor 12 antibody; P2Y(12)R antibody; P2Y(AC) antibody; P2Y(ADP) antibody; P2Y(cyc) antibody; P2Y12 antibody; P2Y12 platelet ADP receptor antibody; P2Y12_HUMAN antibody; platelet ADP receptor antibody; Purinergic receptor P2RY12 antibody; Purinergic receptor P2Y G protein coupled 12 antibody; Purinergic receptor P2Y12 antibody; Putative G protein coupled receptor antibody; SP 1999 antibody; SP1999 antibody;
Synonyms: 2-Methylthioadenosine diphosphate trisodium; 2-Methylthio-ADP trisodium
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2-Methylthioadenosine diphosphate trisodium is a potent purinergic P2Y receptors agonist, with EC50s of 19, 6.2, and 5 nM for human P2Y13, mouse P2Y13 and human P2Y12, respectively. 2-Methylthioadenosine diphosphate trisodium has pEC50s of 8.29 and 5.75 for human P2Y1 and rat P2Y6, respectively. 2-Methylthioadenosine diphosphate trisodium induces platelet aggregation and shape change, and inhibits cyclic AMP accumulation in platelets exposed to prostaglandin E1 .
Synonyms: ACT-246475
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Selatogrel (ACT-246475) is a reversible and selective P2Y12 receptor antagonist which inhibits platelet aggregation with an IC50 of 8 nM. Selatogrel exhibits antithrombotic efficacy .
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(±)-Clopidogrel bisulfate is a platelet P2Y12 receptor inhibitor and an adenosine diphosphate (ADP) receptor antagonist. (±)-Clopidogrel bisulfate inhibits the binding of ADP to its receptors on the membranes of platelet cells, and blocks ADP-mediated activation of the glycoprotein GPIIb/IIIa complex. (±)-Clopidogrel bisulfate reduces vascular inflammation and angiotensin II induced-abdominal aortic aneurysm progression. (±)-Clopidogrel bisulfate has anti-inflammatory effects .
Synonyms: PRT060128
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Elinogrel (PRT060128) is an orally active, selective, competitive, and reversible direct-acting platelet P2Y12 antagonist (IC50 = 20 nM). Elinogrel blocks ADP-induced signaling by directly and reversibly competing for binding to the platelet P2Y12 receptor. Elinogrel exhibits rapid and potent anti-platelet aggregation and antithrombotic activities. Elinogrel is suitable for research into acute coronary syndrome and antithrombotic .
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Trans-R-138727 is the trans isomer of R-138727 (HY-123669). R-138727 is the active metabolite of the antiplatelet agent Prasugrel (HY-15284). R-138727 is an irreversible inhibitor for the platelet receptor P2Y12, and inhibits ADP-induced platelet activation and aggregation .
Cat. No.: HY-108648A
CAS No.: 34983-48-7
Synonyms: 2-Methylthioadenosine diphosphate; 2-Methylthio-ADP
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2-MeSADP is a P2Y receptor agonist, with an EC50 of 5 nM for human P2Y12, EC50 values of 19 nM and 13 nM for human P2Y13, and an EC50 of 6.2 nM for mouse P2Y13. It shows slightly higher selectivity for P2Y12 over human P2Y13. 2-MeSADP triggers increases in intracellular calcium levels, Gi-mediated cAMP inhibition, adenylate cyclase inhibition and downstream signal transduction. 2-MeSADP can be used in research related to glaucoma .
Cat. No.: HY-123669
CAS No.: 204204-73-9
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R-138727, the major active metabolite of Prasugrel (HY-15284), is a highly potent and selective irreversible antagonist of the P2Y12 receptor, with an IC50 of 2.5 μM. R-138727 covalently binds to the P2Y12 receptor on the platelet surface, blocking adenosine diphosphate-mediated platelet activation and aggregation. R-138727 can be used to study stroke, cerebral infarction and neurological deficits.
Cat. No.: HY-77734
CAS No.: 1251765-07-7
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AR-C124910XX is a metabolite of Ticagrelor (HY-10064 ). Ticagrelor is a reversible oral P2Y12 receptor antagonist, and can be used for study of platelet aggregation .
Cat. No.: HY-15284S2
CAS No.: 1189919-49-0
Synonyms: PCR 4099-d4
Cat. No.: HY-123490
CAS No.: 676251-22-2
Synonyms: INS50589
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Regrelor disodium (INS 50589) is a platelet P2Y12 receptor antagonist. Regrelor disodium is a well-tolerated, reversible ADP competitive antagonist. Regrelor disodium inhibits cell proliferation. Regrelor disodium can be used in inflammation-related research .
Cat. No.: HY-136501
CAS No.: 491611-55-3
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MRS2395, an dipivaloyl derivative, is a potent P2Y12 receptor antagonist. MRS2395 inhibits ADP-induced platelet activation with a Ki of 3.6 μM. MRS2395 inhibits cAMP induced by ADP in rat platelets in the presence of PGE1 with an IC50 of 7 µM. MRS2395 enhances platelet dense granule release in response to TRAP-6 .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
