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Results for "

prenylated flavonoid

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Aldose Reductase (1) AP-1 (1) Apoptosis (3) ATP Synthase (1) Autophagy (1) Bacterial (4) COX (3) Cytochrome P450 (1) DNA/RNA Synthesis (1) Drug Derivative (2) Drug Metabolite (1) ERK (3) Estrogen Receptor/ERR (1) Fc Receptor (FcR) (1) Glycosidase (2) HSV (1) Interleukin Related (1) JNK (1) Keap1-Nrf2 (1) NF-κB (5) NO Synthase (1) P-glycoprotein (1) p38 MAPK (3) Phosphatase (1) RANKL/RANK (1) Reactive Oxygen Species (ROS) (1) Reference Standards (1) SARS-CoV (1) Sirtuin (1) STAT (2) Succinate Receptor 1 (1) TNF Receptor (1) Transmembrane Glycoprotein (1) Tyrosinase (1) UGT (1) Virus Protease (1)
By Research Areas:	Cancer (9) Cardiovascular Disease (1) Endocrinology (1) Infection (7) Inflammation/Immunology (5) Metabolic Disease (6) Neurological Disease (2)

By Targets:

Aldose Reductase (1)

AP-1 (1)

Apoptosis (3)

ATP Synthase (1)

Autophagy (1)

Bacterial (4)

COX (3)

Cytochrome P450 (1)

DNA/RNA Synthesis (1)

Drug Derivative (2)

Drug Metabolite (1)

ERK (3)

Estrogen Receptor/ERR (1)

Fc Receptor (FcR) (1)

Glycosidase (2)

HSV (1)

Interleukin Related (1)

JNK (1)

Keap1-Nrf2 (1)

NF-κB (5)

NO Synthase (1)

P-glycoprotein (1)

p38 MAPK (3)

Phosphatase (1)

RANKL/RANK (1)

Reactive Oxygen Species (ROS) (1)

Reference Standards (1)

SARS-CoV (1)

Sirtuin (1)

STAT (2)

Succinate Receptor 1 (1)

TNF Receptor (1)

Transmembrane Glycoprotein (1)

Tyrosinase (1)

UGT (1)

Virus Protease (1)

By Research Areas:

Cancer (9)

Cardiovascular Disease (1)

Endocrinology (1)

Infection (7)

Inflammation/Immunology (5)

Metabolic Disease (6)

Neurological Disease (2)

Inhibitors & Agonists

Natural
Products

Cat. No.	상품명	Target	연구분야	Chemical Structure

HY-N0622

Morusin Maximum Cited Publications 14 Publications Verification Mulberrochromene	NF-κB STAT Bacterial	Infection Inflammation/Immunology Cancer
Morusin is a prenylated flavonoid isolated from Morus alba Linn. with various biological activities, such as antitumor, antioxidant, and anti-bacteria property. Morusin could inhibit NF-κB and STAT3 activity.

HY-N0762

Isobavachin 5 Publications Verification	Cytochrome P450 UGT p38 MAPK NF-κB NO Synthase COX Fc Receptor (FcR) RANKL/RANK Keap1-Nrf2 Reactive Oxygen Species (ROS) Apoptosis Autophagy	Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
Isobavachin is an orally active, blood-brain barrier-penetrating prenylated flavonoid present in Psoralea corylifolia. Isobavachin inhibits human CYP2B6, CYP2C9, CYP2C19, UGT1A1, UGT1A9, and UGT2B7. Isobavachin suppresses MAPK activation, NF-κB nuclear translocation, overexpression of iNOS/COX-2, FcεRI-mediated signaling pathways, and RANKL-induced osteoclastogenesis. Isobavachin induces autophagy, cytotoxicity, neuronal differentiation, and NRF2 activation; it alleviates oxidative damage, inflammatory responses, apoptosis, iron accumulation, mitochondrial biogenesis, and mast cell degranulation. Isobavachin is applicable to research related to liver injury, inflammatory diseases, osteoporosis, liver cancer, prostate cancer, glioma, periodontitis-induced bone loss, and Alzheimer's disease .

HY-126109

(±)-8-Prenylnaringenin	Estrogen Receptor/ERR Apoptosis	Metabolic Disease Endocrinology Cancer
(±)-8-Prenylnaringenin, a natural prenylated flavonoid, is a potent phytoestrogen. (±)-8-Prenylnaringenin is an orally active selective estrogen receptor modulator (SERM) (Estrogen Receptor/ERR) that inhibits ERα and ERβ with IC₅₀s of 57 nM and 68 nM, respectively. (±)-8-Prenylnaringenin has anticancer effects, and can be used for osteoporosis research .

HY-N1910

4'-O-Methylbavachalcone 4 Publications Verification	SARS-CoV Virus Protease Succinate Receptor 1 ERK	Infection Neurological Disease
4'-O-Methylbavachalcone is an orally active prenylated flavonoid that inhibits the activity of SARS-CoV papain-like protease (PLpro), with an IC₅₀ of 10.1 μM and a K_i of 4.6 μM. 4'-O-Methylbavachalcone inhibits poly (ADP-ribose) polymerase-mediated cell death (parthanatos), reduces cerebral infarct volume, binds to the orthosteric site of SUCNR1, blocks the interaction between succinate and SUCNR1, inhibits SUCNR1 activity, blocks the nuclear translocation of NFATc4, suppresses the activation of the ERK1/2 signaling pathway, inhibits cardiomyocyte hypertrophy and restores the expression of α-actinin. 4'-O-Methylbavachalcone can be used in studies related to ischemic stroke, SARS-CoV and cardiomyocyte hypertrophy .

HY-N2732

6-Prenylapigenin 6-Prenyl-4',5,7-trihydroxyflavone; 6-C-Prenylapigenin	Others	Cancer
6-Prenylapigenin (6-Prenyl-4',5,7-trihydroxyflavone; 6-C-Prenylapigenin) is a prenylated flavonoid that exists in the stems and leaves of Maclura pomifera. 6-Prenylapigenin exhibits cytotoxicity against cancer cells such as leukemia cells and solid tumor cells .

HY-N8097

Kushenol W	Bacterial	Infection
Kushenol W is a prenylated flavonoid that can be isolated from the root of Sophora flavescens. Kushenol W has antimicrobial effect, with a MIC of 10 μg/mL for Staphylococcus aureus .

HY-125612

Artonin E 5'-Hydroxymorusin	Apoptosis	Cancer
Artonin E (5'-Hydroxymorusin) is a known prenylated flavonoid that induces apoptosis and arrests the cell cycle in S phase. Artonin E can induce anti-proliferative effects through mitochondrial pathway dysregulation and can be used in cancer research .

HY-107197

8-Prenylchrysin	P-glycoprotein	Cancer
8-prenylchrysin is a C8-prenylated flavonoid. 8-prenylchrysin inhibits P-gp. 8-prenylchrysin can be used for tumor research .

HY-N8095

Kushenol N	Others	Cardiovascular Disease
Kushenol N is a prenylated flavonoid that can be isolated from the root of Sophora flavescens. Kushenol N has anti-allergic and vasorelaxation activities .

HY-N0622R

Morusin (Standard) Mulberrochromene (Standard)	NF-κB Reference Standards STAT Bacterial	Infection Inflammation/Immunology Cancer
Morusin (Standard) is the analytical standard of Morusin. This product is intended for research and analytical applications. Morusin is a prenylated flavonoid isolated from Morus alba Linn. with various biological activities, such as antitumor, antioxidant, and anti-bacteria property. Morusin could inhibit NF-κB and STAT3 activity.

HY-N8265

Abyssinone V	HSV DNA/RNA Synthesis ATP Synthase	Infection
Abyssinone V is a prenylated flavonoid with predicted anti-viral activity. Abyssinone V can be isolated from the stem bark of Erythrina melanacantha. Abyssinone V possesses good pharmacodynamics properties. Abyssinone V is predicted to be antivirals including anti-herpes (HSV) agent, with mechanisms comprising inhibition of polymerase, ATPase and membrane integrity .

HY-N10009

Cudraflavone B	NF-κB TNF Receptor COX ERK p38 MAPK Sirtuin	Inflammation/Immunology
Cudraflavone B is a prenylated flavonoid with anti-inflammatory and anti-tumor properties. Cudraflavone B is also a dual inhibitor of COX-1 and COX-2. Cudraflavone B blocks the translocation of nuclear factor κB (NF-κB) from the cytoplasm to the nucleus in macrophages. Thus, Cudraflavone B inhibits tumor necrosis factor α (TNFα) gene expression and secretion. Cudraflavone B also triggers the mitochondrial apoptotic pathway, activates NF-κB, the MAPK p38, and ERK, and induced the expression of SIRT1. Thus Cudraflavone B inhibits the growth of human oral squamous cell carcinoma cells .

HY-N10952

Epicornuin F	Others	Cancer
Epicornuin F is a prenylated flavonoid. Epicornuin F can be isolated from the leaves of Epimedium brevicornu. Epicornuin F has the cytotoxic activity against HepG2 cells with an IC₅₀ value of 33.4 μM. Epicornuin F can be used for the research of cancer .

HY-N3776

Dorsmanin A	Others	Others
Dorsmanin A is a prenylated flavonoid from the twigs of Dorstenia mannii .

HY-N11841

Mortatarin G	Glycosidase	Metabolic Disease
Mortatarin G (compound 3) is a prenylated flavonoid, that can be isolated from mulberry leaves. Mortatarin G exhibits good α-glucosidase inhibitory activity, with an IC₅₀ of 20.4±1.4 μM .

HY-179401

Morunigrol B	Drug Derivative	Others
Morunigrol B is a prenylated flavonoid that can be found in the barks of Morus nigra .

HY-N3716

Dehydroglyasperin D	Aldose Reductase COX	Metabolic Disease Inflammation/Immunology
Dehydroglyasperin D inhibits rat and human Aldose Reductase (AR) (IC₅₀: 62.4 μM and 176.2 μM respectively). Dehydroglyasperin D has anti-obesity, antioxidant effects. Dehydroglyasperin D shows anti-inflammatory activity by inhibiting COX-2 expression and the MLK3 signaling pathway. Dehydroglyasperin D also inhibits melanin synthesis. Dehydroglyasperin D is a prenylated flavonoid that can be isolated from Glycyrrhiza uralensi .

HY-107196

Gancaonin P	Others	Others
Gancaonin P (Compound 5) is a prenylated flavonoid found in the aerial parts of Glycyrrhiza uralensis FISCH. et DC .

HY-N13016

Yinyanghuo C	Transmembrane Glycoprotein	Cancer
Yinyanghuo C is a prenylated flavonoid isolated from the leaves of Epimedium sagittatum. Yinyanghuo C increases the mRNA expression levels of endothelial cell markers and enhances cancer-associated angiogenesis in the 4T1 breast tumor-bearing model .

HY-N16798

Sanggenon M	Drug Derivative	Others
Sanggenon M is a natural phenolic compound.

HY-N17601

Parvisoflavone B	Phosphatase Glycosidase	Metabolic Disease
Parvisoflavone B is a prenylated flavonoid. Parvisoflavone B can be isolated from root bark of Erythrina mildbraedii. Parvisoflavone B inhibits PTP1B activity with an IC₅₀ of 42.6 μM. Parvisoflavone B inhibits α-glucosidase with an IC₅₀ of 12.19 μM. Parvisoflavone B can be used in the research of type 2 diabetes and obesity .

HY-N16699

4'-O-Methyl-8-prenylnaringenin	Bacterial	Infection
4'-O-Methyl-8-prenylnaringenin is a prenylated flavonoid compound with antibacterial activity, which can be isolated from propolis of the Solomon Islands. 4'-O-Methyl-8-prenylnaringenin exerts its antibacterial activity by enhancing cell penetration and damaging bacterial cell membranes or cell walls. The minimum inhibitory concentrations (MICs) against Staphylococcus aureus, Bacillus subtilis, and Pseudomonas aeruginosa are 32 μg/mL, 32 μg/mL, and 128 μg/mL, respectively .

HY-N18197

Norkurarinol	Tyrosinase NF-κB AP-1 Interleukin Related p38 MAPK JNK ERK	Infection
Norkurarinol is a prenylated flavonoid. Norkurarinol can be isolated from Sophora flavescens. Norkurarinol potently inhibits mushroom Tyrosinase DOPA oxidase activity with an IC₅₀ of 2.1 μM. Norkurarinol inhibits poly(I:C)-induced NF-κB/AP-1 activation. Norkurarinol inhibits pro-inflammatory cytokines (TNF-α, IL-6). Norkurarinol inhibits phosphorylation of p38, JNK, and ERK1/2. Norkurarinol increases phosphorylation of IRF3. Norkurarinol has antiviral activity against Rotavirus KJ56-1

HY-N19800

Anhydroicaritin-3,7-di-O-glucuronide	Drug Metabolite	Metabolic Disease
Anhydroicaritin-3,7-di-O-glucuronide is a diglucuronide metabolite of icaritin. Anhydroicaritin-3,7-di-O-glucuronide is also a conjugated metabolite derived from prenylated flavonoids of the genus Epimedium in rats. In an in vitro microsomal system, Anhydroicaritin-3,7-di-O-glucuronide is mainly catalyzed by UGT1A1 and UGT1A8. Anhydroicaritin-3,7-di-O-glucuronide is generated via sequential glucuronidation at the 3-OH and 7-OH sites of icaritin, or via further conversion from monoglucuronides of icaritin .

Morusin Maximum Cited Publications 14 Publications Verification Mulberrochromene	Infection Flavonoids other families Classification of Application Fields Flavones Anti-aging Phenols Polyphenols Plants Inflammation/Immunology Disease Research Fields Source Classification	NF-κB STAT Bacterial
Morusin is a prenylated flavonoid isolated from Morus alba Linn. with various biological activities, such as antitumor, antioxidant, and anti-bacteria property. Morusin could inhibit NF-κB and STAT3 activity.

Isobavachin 5 Publications Verification	Structural Classification Flavonoids Neurological Disease Classification of Application Fields Leguminosae Flavonones Phenols Polyphenols Psoralea corylifolia L. Plants Disease Research Fields Source Classification	Cytochrome P450 UGT p38 MAPK NF-κB NO Synthase COX Fc Receptor (FcR) RANKL/RANK Keap1-Nrf2 Reactive Oxygen Species (ROS) Apoptosis Autophagy
Isobavachin is an orally active, blood-brain barrier-penetrating prenylated flavonoid present in Psoralea corylifolia. Isobavachin inhibits human CYP2B6, CYP2C9, CYP2C19, UGT1A1, UGT1A9, and UGT2B7. Isobavachin suppresses MAPK activation, NF-κB nuclear translocation, overexpression of iNOS/COX-2, FcεRI-mediated signaling pathways, and RANKL-induced osteoclastogenesis. Isobavachin induces autophagy, cytotoxicity, neuronal differentiation, and NRF2 activation; it alleviates oxidative damage, inflammatory responses, apoptosis, iron accumulation, mitochondrial biogenesis, and mast cell degranulation. Isobavachin is applicable to research related to liver injury, inflammatory diseases, osteoporosis, liver cancer, prostate cancer, glioma, periodontitis-induced bone loss, and Alzheimer's disease .

(±)-8-Prenylnaringenin	Structural Classification Flavonoids Humulus lupulus L. Flavonones Plants Moraceae Source Classification	Estrogen Receptor/ERR Apoptosis
(±)-8-Prenylnaringenin, a natural prenylated flavonoid, is a potent phytoestrogen. (±)-8-Prenylnaringenin is an orally active selective estrogen receptor modulator (SERM) (Estrogen Receptor/ERR) that inhibits ERα and ERβ with IC₅₀s of 57 nM and 68 nM, respectively. (±)-8-Prenylnaringenin has anticancer effects, and can be used for osteoporosis research .

4'-O-Methylbavachalcone 4 Publications Verification	Infection Structural Classification Chalcones Flavonoids Classification of Application Fields Leguminosae Phenols Polyphenols Psoralea corylifolia L. Plants Disease Research Fields Source Classification	SARS-CoV Virus Protease Succinate Receptor 1 ERK
4'-O-Methylbavachalcone is an orally active prenylated flavonoid that inhibits the activity of SARS-CoV papain-like protease (PLpro), with an IC₅₀ of 10.1 μM and a K_i of 4.6 μM. 4'-O-Methylbavachalcone inhibits poly (ADP-ribose) polymerase-mediated cell death (parthanatos), reduces cerebral infarct volume, binds to the orthosteric site of SUCNR1, blocks the interaction between succinate and SUCNR1, inhibits SUCNR1 activity, blocks the nuclear translocation of NFATc4, suppresses the activation of the ERK1/2 signaling pathway, inhibits cardiomyocyte hypertrophy and restores the expression of α-actinin. 4'-O-Methylbavachalcone can be used in studies related to ischemic stroke, SARS-CoV and cardiomyocyte hypertrophy .

6-Prenylapigenin 6-Prenyl-4',5,7-trihydroxyflavone; 6-C-Prenylapigenin	Structural Classification Flavonoids Flavones Maclura pomifera (Raf.) Schneid. Plants Moraceae Source Classification	Others
6-Prenylapigenin (6-Prenyl-4',5,7-trihydroxyflavone; 6-C-Prenylapigenin) is a prenylated flavonoid that exists in the stems and leaves of Maclura pomifera. 6-Prenylapigenin exhibits cytotoxicity against cancer cells such as leukemia cells and solid tumor cells .

Kushenol W	Infection Flavonoids Classification of Application Fields Leguminosae Flavonones Phenols Polyphenols Plants Sophora flavescens Aiton Disease Research Fields Source Classification	Bacterial
Kushenol W is a prenylated flavonoid that can be isolated from the root of Sophora flavescens. Kushenol W has antimicrobial effect, with a MIC of 10 μg/mL for Staphylococcus aureus .

Kushenol N	Cardiovascular Disease Flavanonols Flavonoids Classification of Application Fields Leguminosae Phenols Polyphenols Plants Sophora flavescens Aiton Disease Research Fields Source Classification	Others
Kushenol N is a prenylated flavonoid that can be isolated from the root of Sophora flavescens. Kushenol N has anti-allergic and vasorelaxation activities .

Morusin (Standard) Mulberrochromene (Standard)	Structural Classification Flavonoids other families Flavones Phenols Polyphenols Plants Source Classification	NF-κB Reference Standards STAT Bacterial
Morusin (Standard) is the analytical standard of Morusin. This product is intended for research and analytical applications. Morusin is a prenylated flavonoid isolated from Morus alba Linn. with various biological activities, such as antitumor, antioxidant, and anti-bacteria property. Morusin could inhibit NF-κB and STAT3 activity.

Abyssinone V	Flavonoids Leguminosae Flavonones Erythrina melanacantha Taub. ex Harms Plants Source Classification	HSV DNA/RNA Synthesis ATP Synthase
Abyssinone V is a prenylated flavonoid with predicted anti-viral activity. Abyssinone V can be isolated from the stem bark of Erythrina melanacantha. Abyssinone V possesses good pharmacodynamics properties. Abyssinone V is predicted to be antivirals including anti-herpes (HSV) agent, with mechanisms comprising inhibition of polymerase, ATPase and membrane integrity .

Cudraflavone B	Brosimopsis oblongifolia Phenols Polyphenols Plants Moraceae Source Classification	NF-κB TNF Receptor COX ERK p38 MAPK Sirtuin
Cudraflavone B is a prenylated flavonoid with anti-inflammatory and anti-tumor properties. Cudraflavone B is also a dual inhibitor of COX-1 and COX-2. Cudraflavone B blocks the translocation of nuclear factor κB (NF-κB) from the cytoplasm to the nucleus in macrophages. Thus, Cudraflavone B inhibits tumor necrosis factor α (TNFα) gene expression and secretion. Cudraflavone B also triggers the mitochondrial apoptotic pathway, activates NF-κB, the MAPK p38, and ERK, and induced the expression of SIRT1. Thus Cudraflavone B inhibits the growth of human oral squamous cell carcinoma cells .

Epicornuin F	Flavonoids Phenols Epimedium brevicornu Maxim. Plants Berberidaceae Isoflavones Source Classification	Others
Epicornuin F is a prenylated flavonoid. Epicornuin F can be isolated from the leaves of Epimedium brevicornu. Epicornuin F has the cytotoxic activity against HepG2 cells with an IC₅₀ value of 33.4 μM. Epicornuin F can be used for the research of cancer .

Dorsmanin A	Monophenols Phenols Plants Moraceae Dorstenia mannii Hook.f. Source Classification	Others
Dorsmanin A is a prenylated flavonoid from the twigs of Dorstenia mannii .

Mortatarin G	Flavanonols Flavonoids Phenols Polyphenols Morus alba L. Plants Moraceae Source Classification	Glycosidase
Mortatarin G (compound 3) is a prenylated flavonoid, that can be isolated from mulberry leaves. Mortatarin G exhibits good α-glucosidase inhibitory activity, with an IC₅₀ of 20.4±1.4 μM .

Morunigrol B	Structural Classification Flavonoids Morus nigra Linn. Plants Moraceae Other Flavonoids Source Classification	Drug Derivative
Morunigrol B is a prenylated flavonoid that can be found in the barks of Morus nigra .

Dehydroglyasperin D	Leguminosae Phenols Polyphenols Plants Glycyrrhiza uralensis Fisch. Source Classification	Aldose Reductase COX
Dehydroglyasperin D inhibits rat and human Aldose Reductase (AR) (IC₅₀: 62.4 μM and 176.2 μM respectively). Dehydroglyasperin D has anti-obesity, antioxidant effects. Dehydroglyasperin D shows anti-inflammatory activity by inhibiting COX-2 expression and the MLK3 signaling pathway. Dehydroglyasperin D also inhibits melanin synthesis. Dehydroglyasperin D is a prenylated flavonoid that can be isolated from Glycyrrhiza uralensi .

Gancaonin P	Structural Classification Flavonols Flavonoids Leguminosae Plants Glycyrrhiza uralensis Fisch. Source Classification	Others
Gancaonin P (Compound 5) is a prenylated flavonoid found in the aerial parts of Glycyrrhiza uralensis FISCH. et DC .

Yinyanghuo C	Structural Classification Flavonoids Epimedium sagittatum (Siebold & Zucc.) Maxim. Plants Berberidaceae Other Flavonoids Source Classification	Transmembrane Glycoprotein
Yinyanghuo C is a prenylated flavonoid isolated from the leaves of Epimedium sagittatum. Yinyanghuo C increases the mRNA expression levels of endothelial cell markers and enhances cancer-associated angiogenesis in the 4T1 breast tumor-bearing model .

Sanggenon M	Structural Classification Flavonoids Morus alba L. Plants Moraceae Other Flavonoids Source Classification	Drug Derivative
Sanggenon M is a natural phenolic compound.

Parvisoflavone B	Structural Classification Flavonoids Ficus nervosa B. Heyne ex Roth Flavones Plants Moraceae Source Classification	Phosphatase Glycosidase
Parvisoflavone B is a prenylated flavonoid. Parvisoflavone B can be isolated from root bark of Erythrina mildbraedii. Parvisoflavone B inhibits PTP1B activity with an IC₅₀ of 42.6 μM. Parvisoflavone B inhibits α-glucosidase with an IC₅₀ of 12.19 μM. Parvisoflavone B can be used in the research of type 2 diabetes and obesity .

4'-O-Methyl-8-prenylnaringenin	Structural Classification Flavonoids Animals Flavonones Source Classification	Bacterial
4'-O-Methyl-8-prenylnaringenin is a prenylated flavonoid compound with antibacterial activity, which can be isolated from propolis of the Solomon Islands. 4'-O-Methyl-8-prenylnaringenin exerts its antibacterial activity by enhancing cell penetration and damaging bacterial cell membranes or cell walls. The minimum inhibitory concentrations (MICs) against Staphylococcus aureus, Bacillus subtilis, and Pseudomonas aeruginosa are 32 μg/mL, 32 μg/mL, and 128 μg/mL, respectively .

Norkurarinol	Structural Classification Flavonoids Leguminosae Flavonones Sophora flavescens Aiton Plants Source Classification	Tyrosinase NF-κB AP-1 Interleukin Related p38 MAPK JNK ERK
Norkurarinol is a prenylated flavonoid. Norkurarinol can be isolated from Sophora flavescens. Norkurarinol potently inhibits mushroom Tyrosinase DOPA oxidase activity with an IC₅₀ of 2.1 μM. Norkurarinol inhibits poly(I:C)-induced NF-κB/AP-1 activation. Norkurarinol inhibits pro-inflammatory cytokines (TNF-α, IL-6). Norkurarinol inhibits phosphorylation of p38, JNK, and ERK1/2. Norkurarinol increases phosphorylation of IRF3. Norkurarinol has antiviral activity against Rotavirus KJ56-1

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prenylated flavonoid

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