8 Results for "

rat brain protein kinase C

" in MedChemExpress (MCE) Product Catalog:
Products (8)

8 Results for "rat brain protein kinase C" in MCE Product Catalog:

1
1 Cited Publications
Cat. No.: HY-129624A
CAS No.: 138516-31-1
Purity:  99.68%
Synonyms: Ro 31-7549 acetate; Bis VIII acetate
Target:  

PKC Apoptosis

Research Areas:  

Inflammation/Immunology Cancer

Bisindolylmaleimide VIII acetate (Ro 31-7549 acetate) is a potent and selective protein kinase C (PKC) inhibitor with an IC50 of 158 nM for rat brain PKC. Bisindolylmaleimide VIII acetate has IC50s of 53, 195, 163, 213, and 175 nM for PKC-α, PKC-βI, PKC-βII, PKC-γ, PKC-ε, respectively . Bisindolylmaleimide VIII acetate facilitates Fas-mediated apoptosis and inhibits T cell-mediated autoimmune diseases .
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Cat. No.: HY-W011297
CAS No.: 2566-89-4
Synonyms: Arachidonic acid methyl ester
Target:  

PKC

Research Areas:  

Metabolic Disease

Methyl arachidonate is a protein kinase C activator and also an orally active substrate that undergoes esterase-mediated hydrolysis. Methyl arachidonate indirectly activates protein kinase C via eicosanoid metabolites generated through the arachidonic acid metabolic pathway, exerting effects via cyclooxygenase products at low concentrations and via lipoxygenase products at high concentrations. Methyl arachidonate can be used in studies related to lipodystrophy .
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Cat. No.: HY-126419
CAS No.: 124027-58-3
Purity:  99.90%
Kobophenol A, an oligomeric stilbene, blocks the interaction between the ACE2 receptor and S1-RBD with an IC50 of 1.81 μM and inhibits SARS-CoV-2 viral infection in cells with an EC50 of 71.6 μM. Kobophenol A inhibits the activity of partially purified rat brain protein kinase C (PKC) with an IC50 of 52 µM .
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Cat. No.: HY-129624
CAS No.: 125313-65-7
Synonyms: Ro 31-7549; Bis VIII
Target:  

PKC Apoptosis

Research Areas:  

Inflammation/Immunology Cancer

Bisindolylmaleimide VIII (Ro 31-7549) is a potent and selective protein kinase C (PKC) inhibitor with an IC50 of 158 nM for rat brain PKC. Bisindolylmaleimide VIII has IC50s of 53, 195, 163, 213, and 175 nM for PKC-α, PKC-βI, PKC-βII, PKC-γ, PKC-ε, respectively . Bisindolylmaleimide VIII facilitates Fas-mediated apoptosis and inhibits T cell-mediated autoimmune diseases .
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Cat. No.: HY-N19735
CAS No.: 144678-18-2
MS-347a is an inhibitor of myosin light chain kinase (MLCK) and protein kinase C (PKC), with IC50 values of 9.2 μM, 31 μM and 16 μM against calmodulin-dependent MLCK, calmodulin-independent MLCK and PKC, respectively. MS-347a binds to the catalytic domain of MLCK and blocks both calmodulin-dependent and calmodulin-independent MLCK activity. MS-347a inhibits the growth of drug-sensitive fission yeast and multiple ascomycete phytopathogenic fungi. MS-347a exhibits fungicidal activity against a variety of phytopathogenic fungi and protective activity against Magnaporthe oryzae in rice seedlings. MS-347a shows antibacterial activity against specific Gram-positive bacteria and Proteus vulgaris. MS-347a can be used in studies related to rice blast, bacterial infections and phytopathogenic fungal diseases .
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Cat. No.: HY-N19702
CAS No.: 124824-06-2
Calphostin B is a protein kinase C (PKC) inhibitor with an IC50 of 1.04 μM in rats and an IC50 of 22.9 μM for bovine cyclic adenosine monophosphate-dependent protein kinase (PKA). Calphostin B bears aromatic structures at positions C-14 and C-17, which accounts for its higher selectivity for PKC over PKA. Calphostin B can be used in studies related to human cervical cancer and human breast cancer .
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Cat. No.: HY-114554
CAS No.: 103370-21-4
KS 619-1 is a Ca 2+/calmodulin-dependent cyclic nucleotide phosphodiesterase inhibitor. KS 619-1 exhibits strong inhibitory activity against this enzyme derived from bovine brain and heart, but shows weak inhibitory effects on calmodulin-independent phosphodiesterase and protein kinase C. KS 619-1 displays weak antibacterial activity against Staphylococcus aureus .
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Cat. No.: HY-N19701
CAS No.: 124857-59-6
Calphostin I is a selective protein kinase C (PKC) inhibitor with an IC50 of 0.14 μM in rats. Calphostin I interacts with the regulatory domain of PKC, and the aromatic groups at its C-14 and C-17 positions contribute to enhanced potency and selectivity, with no inhibition of cyclic adenosine monophosphate-dependent protein kinase (PKA) at high concentrations. Calphostin I can be used in research related to cervical cancer and breast cancer .
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