144678-18-2
Chemical Structure
MS-347a
- CAS No.: 144678-18-2
- Formula:C16H12O7
- Molecular Weight:316.26
InChIKey: DYSASOJNGXSFHH-UHFFFAOYSA-N
SMILES: O=C(C12OC1C=CC(OC3=CC(CO)=CC(O)=C34)=C2C4=O)OC
Biological Activity: MS-347a is an inhibitor of myosin light chain kinase (MLCK) and protein kinase C (PKC), with IC50 values of 9.2 μM, 31 μM and 16 μM against calmodulin-dependent MLCK, calmodulin-independent MLCK and PKC, respectively. MS-347a binds to the catalytic domain of MLCK and blocks both calmodulin-dependent and calmodulin-independent MLCK activity. MS-347a inhibits the growth of drug-sensitive fission yeast and multiple ascomycete phytopathogenic fungi. MS-347a exhibits fungicidal activity against a variety of phytopathogenic fungi and protective activity against Magnaporthe oryzae in rice seedlings. MS-347a shows antibacterial activity against specific Gram-positive bacteria and Proteus vulgaris. MS-347a can be used in studies related to rice blast, bacterial infections and phytopathogenic fungal diseases[1][2][3][4].
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MS-347a | MS-347a is an inhibitor of myosin light chain kinase (MLCK) and protein kinase C (PKC), with IC50 values of 9.2 μM, 31 μM and 16 μM against calmodulin-dependent MLCK, calmodulin-independent MLCK and PKC, respectively. MS-347a binds to the catalytic domain of MLCK and blocks both calmodulin-dependent and calmodulin-independent MLCK activity. MS-347a inhibits the growth of drug-sensitive fission yeast and multiple ascomycete phytopathogenic fungi. MS-347a exhibits fungicidal activity against a variety of phytopathogenic fungi and protective activity against Magnaporthe oryzae in rice seedlings. MS-347a shows antibacterial activity against specific Gram-positive bacteria and Proteus vulgaris. MS-347a can be used in studies related to rice blast, bacterial infections and phytopathogenic fungal diseases. | |||||||||||||||||||||
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References
- [1]. Nakanishi S, et al. MS-347a, a new inhibitor of myosin light chain kinase from Aspergillus sp. KY52178. The Journal of antibiotics. 1993 Dec;46(12):1775-81. [Content Brief]
- [2]. Honma S, et al. Re-discovery of MS-347a as a Fungicide Candidate through a New Drug Discovery Platform with a Multidrug-Sensitive Saccharomyces cerevisiae Screening System and the Introduction of a Global Secondary Metabolism Regulator, laeA Gene. Biosci Biotechnol Biochem. 2024;88:824-829. [Content Brief]
- [3]. Kimishima A, et al. Synthesis and biological evaluation of MS-347a derivatives against plant pathogenic fungi based on a strategy of gene introduction. Journal of pesticide science. 2024 Nov 20;49(4):224-231. [Content Brief]
- [4]. Kimishima A, et al. Construction of a New Drug and Agrochemical Candidates Screening Platform Utilizing Drug-Hypersensitive Fission Yeast to Discover Overlooked Natural Products. Journal of natural products. 2025 Sep 26;88(9):2090-2096. [Content Brief]
