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Results for "

retinoid receptors

" in MedChemExpress (MCE) Product Catalog:

By Targets:	RAR/RXR (48) Apoptosis (11) Autophagy (24) Drug Metabolite (5) Endogenous Metabolite (5) Environmental Pollutants (1) HCV (2) Interleukin Related (1) Isotope-Labeled Compounds (8) LXR (1) NO Synthase (1) Reactive Oxygen Species (ROS) (3) Reference Standards (14) ROR (7) SphK (2) Tyrosine Hydroxylase (1) VD/VDR (3) Wnt (1) β-catenin (1)
By Research Areas:	Cancer (40) Infection (2) Inflammation/Immunology (11) Metabolic Disease (12) Neurological Disease (13)

Inhibitors & Agonists

Fluorescent Dyes

Biochemical Assay Reagents

Natural
Products

Isotope-Labeled Compounds

GMP Molecules

Targets Recommended: RAR/RXR

Cat. No.	Nombre del producto	Target	Áreas de investigación	Chemical Structure

HY-14171

Bexarotene 20+ Cited Publications LGD1069	RAR/RXR Autophagy	Cancer
Bexarotene (LGD1069) is a high-affinity and selective retinoid X receptors (RXR) agonist with EC₅₀s of 33, 24, 25 nM for RXRα, RXRβ, and RXRγ, respectively. Bexarotene shows limited affinity for RAR receptors (EC₅₀ >10000 nM) . Bexarotene can be used for the research of cutaneous T-cell lymphoma.

HY-N0155

Nobiletin 25+ Cited Publications	ROR Reactive Oxygen Species (ROS) Apoptosis Autophagy	Neurological Disease Inflammation/Immunology Cancer
Nobiletin is a poly-methoxylated flavone from the citrus peel that improves memory loss. Nobiletin is a retinoid acid receptor-related orphan receptors (RORs) agonist. Nobiletin can reduce reactive oxygen species (ROS) levels in differentiated C2C12 myotubes and has anti-inflammation and anti-cancer properties, including anti-angiogenesis, anti-proliferation, anti-metastasis and induced apoptosis .

HY-15373

Fenretinide 5+ Cited Publications 4-HPR; ISLA-101	RAR/RXR Autophagy	Cancer
Fenretinide (4-HPR) is a synthetic retinoid deriverative, binding to the retinoic acid receptors (RAR) at concentrations necessary to induce cell death.

HY-U00449

AGN 193109 5+ Cited Publications	RAR/RXR	Cancer
AGN 193109 is a retinoid analog, and acts as a specific and highly effective antagonist of *retinoic acid receptors* (RARs), with K_ds of 2 nM, 2 nM, and 3 nM for RARα, RARβ, and RARγ**, respectively. AGN 193109 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. AGN 193109 is the antidote for retinoic acidosis, that ameliorates the skin and mucosal toxicity.

HY-107500

UVI 3003 5+ Cited Publications	RAR/RXR Autophagy	Others
UVI 3003 is a highly selective antagonist of retinoid X receptor (RXR), and inhibits xenopus and human RXRα in Cos7 cells, with IC₅₀s of 0.22 and 0.24 μM, respectively.

HY-15340

LG100268 5 Publications Verification LG268	RAR/RXR Autophagy	Metabolic Disease
LG100268 (LG268) is a potent, selective and orally active retinoid X receptor (RXR) agonist with EC₅₀ values of 4 nM, 3 nM, and 4 nM for RXR-α, RXR-β, and RXR-γ, respectively . LG100268 displays >1000-fold selectivity for RXR over RAR, the K_i values are 3.4 nM, 6.2 nM and 9.2 nM for RXR-α, RXR-β, and RXR-γ, respectively . LG100268 activates RXR homodimers to induce transcriptional activation. LG100268 can be used for the study of lung carcinogenesisy .

HY-107399

CD3254 3 Publications Verification	RAR/RXR	Metabolic Disease Cancer
CD3254 a potent and selective retinoid-X-receptor (RXR) agonist .

HY-A0067

Oxybenzone 5+ Cited Publications Benzophenone 3	Environmental Pollutants Autophagy RAR/RXR Apoptosis	Neurological Disease
Oxybenzone (Benzophenone 3) is a commonly used UV filter in sun tans and skin protectants. Oxybenzone act as endocrine disrupting chemicals (EDCs) and can pass through the placental and blood-brain barriers. Benzophenone-3 impairs autophagy, alters epigenetic status, and disrupts **retinoid X receptor** signaling in apoptotic neuronal cells .

HY-107397

Ch55 2 Publications Verification	RAR/RXR	Cancer
Ch55 is a potent synthetic retinoid. Ch55 binds to RAR-α and RAR-β receptors with high affinity. Ch55 displays low affinity for cellular retinoic acid binding protein (CRABP). Ch55 is a potent inducer of the differentiation of HL60 cells with an EC₅₀ of 200 nM. Ch55 can be used for cancer research .

HY-32350

Ercalcitriol 3 Publications Verification 1α,25-Dihydroxy Vitamin D2	VD/VDR Drug Metabolite Endogenous Metabolite	Metabolic Disease
Ercalcitriol (1α,25-Dihydroxy Vitamin D2) is a *vitamin D receptor* (VDR)** agonist with high binding affinity. After binding to VDR, Ercalcitriol forms a complex with retinoid X receptor (RXR) to regulate target gene transcription. For example, Ercalcitriol induces human gingival/oral epithelial cells to produce human cat antimicrobial peptide (hCAP-18/LL-37), which has antimicrobial activity against periodontal pathogens such as Porphyromonas gingivalis. Ercalcitriol enhances the innate immune defense of the oral mucosa by promoting the expression of antimicrobial peptides, and is mainly used in the study of periodontal diseases and immune-related oral diseases .

HY-100008

Peretinoin 5+ Cited Publications NIK333	RAR/RXR SphK Autophagy HCV	Infection Cancer
Peretinoin is an oral acyclic retinoid with a vitamin A-like structure that targets retinoid nuclear receptors such as retinoid X receptor (RXR) and *retinoic acid receptor* (RAR). Peretinoin reduces the mRNA level of sphingosine kinase 1 (SPHK1) in vitro by downregulating a transcription factor, Sp1 . Peretinoin prevents the progression of non-alcoholic steatohepatitis (NASH) and the development of hepatocellular carcinoma (HCC) through activating the autophagy pathway by increased Atg16L1 expression . Peretinoin inhibits HCV** RNA amplification and virus release by altering lipid metabolism with a EC₅₀ of 9 μM .

HY-101108

Tazarotenic acid 2 Publications Verification AGN 190299	Drug Metabolite	Others
Tazarotenic acid is the metabolite of Tazarotene. Tazarotenic acid binding to retinoic acid receptors (RARs) is the probable molecular target of retinoid action. Tazarotenic acid has the potential for the research of warty dyskeratoma .

HY-132810

Bevurogant BI 730357	ROR	Inflammation/Immunology Cancer
Bevurogant (BI 730357) is a retinoid-related *orphan receptor-gamma t (RORγt)* antagonist. Bevurogant can be used for the research of chronic inflammatory diseases .

HY-116506

Bigelovin	RAR/RXR Reactive Oxygen Species (ROS) Apoptosis Autophagy	Cancer
Bigelovin, a sesquiterpene lactone isolated from Inula hupehensis, is a selective retinoid X receptor α agonist. Bigelovin suppresses tumor growth through inducing apoptosis and autophagy via the inhibition of mTOR pathway regulated by ROS generation .

HY-153832

MSU-42011	RAR/RXR NO Synthase	Cancer
MSU-42011 is an orally active retinoid X receptor (RXR) agonist. MSU-42011 inhibits the iNOS activity and reduces the expression of p-ERK protein. MSU-42011 has immunomodulatory and antitumor activity .

HY-14653

Amsilarotene TAC-101; Am 555S	RAR/RXR Apoptosis	Cancer
Amsilarotene (TAC-101; Am 555S), an orally active synthetic retinoid, has selective affinity for *retinoic acid receptor* α (RAR-α) binding with K_i of 2.4, 400 nM for RAR-α and RAR-β. Amsilarotene induces the apoptotic** of human gastric cancer, hepatocellular carcinoma and ovarian carcinoma cells. Amsilarotene can be used for the research of cancer .

HY-W107616

3,7,11,15-Tetramethyl-2-hexadecen-1-ol	Endogenous Metabolite	Others
3,7,11,15-Tetramethyl-2-hexadecen-1-ol can be used to synthesize vitamin E and vitamin E's precursor vitamin K1. 3,7,11,15-Tetramethyl-2-hexadecen-1-ol regulates transcription in cells through the transcription factor PPAR-alpha and the retinoid X receptor (RXR)43 .

HY-120875

HX600	RAR/RXR	Neurological Disease
HX600 is a synthetic agonist for RXR (Retinoid X Receptor) heterodimer complex. HX600 prevents ischemia-induced neuronal damage. HX600 has orally bioactivity .

HY-14171S

Bexarotene-d4 LGD1069 d₄	RAR/RXR Autophagy	Cancer
Bexarotene-d₄ is a deuterium labeled Bexarotene (LGD1069). Bexarotene (LGD1069) is a selective retinoid X receptors (RXR) agonist for the treatment of cutaneous T-cell lymphoma .

HY-106735

Arotinoid Ro 13-6298; Arotinoid ethyl ester	RAR/RXR	Inflammation/Immunology Cancer
Arotinoid (RO 13-6298) is a retinoid, and acts as an orally active and highly potent agonist of retinoic acid receptors (RARs) with antipsoriatic effects. Arotinoid has antipapiltoma activity with an ED₅₀ of 0.05 mg/kg. Arotinoid can be used for the research of skin carcinomas .

HY-124136

WYC-209 1 Publications Verification	RAR/RXR Apoptosis Autophagy	Cancer
WYC-209, a synthetic retinoid, is a *retinoic acid receptor* (RAR) agonist. WYC-209 induces apoptosis primarily via the caspase 3 pathway (IC₅₀**=0.19 μM for inmalignant murine melanoma TRCs), and has long-term effects with little toxicity .

HY-A0067S

Oxybenzone-d5	RAR/RXR Apoptosis Autophagy	Neurological Disease
Oxybenzone-d₅ is the deuterium labeled Oxybenzone . Oxybenzone (Benzophenone 3) is a commonly used UV filter in sun tans and skin protectants. Oxybenzone act as endocrine disrupting chemicals (EDCs) and can pass through the placental and blood-brain barriers. Benzophenone-3 impairs autophagy, alters epigenetic status, and disrupts retinoid X receptor signaling in apoptotic neuronal cells .

HY-108525

Fluorobexarotene	RAR/RXR	Cancer
Fluorobexarotene (compound 20) is a potent retinoid-X-receptor (RXR) agonist, with a K_i value of 12 nM and an EC₅₀ value of 43 nM for RXRα receptor. Fluorobexarotene possesses an apparent RXR binding affinity that is 75% greater than Bexarotene .

HY-104070

LG-100064	RAR/RXR Autophagy	Cancer
LG-100064 is a retinoid-X-receptor (RXR) agonist, with EC₅₀s of 330 nM, 200 nM, and 260 nM for RXRα, RXRβ and RXRγ; LG-100064 can be used in the research of cancer.

HY-144377

RXR antagonist 1	RAR/RXR	Neurological Disease Metabolic Disease Cancer
RXR antagonist 1 (compound 6a) is a retinoid X receptor (RXR) modulator. RXR antagonist 1 shows potent RXR-antagonistic activity, with a pA₂ of 8.06. RXR antagonist 1 can be used for type 2 diabetes research .

HY-155437

NEt-iFQ	RAR/RXR	Others
NEt-iFQ is a fluorescent retinoid X receptor (RXR) agonist with potent solvatochromic properties. NEt-iFQ selectively binds to RXR-LBP and fluoresces .

HY-117376

(all-E)-UAB30 UAB30	RAR/RXR	Cancer
(all-E)-UAB30 (UAB30) is an retinoid X receptor (RXR) selective agonist.(all-E)-UAB30 shows anti-proliferation activity for MyLa, HuT 78, and HH cells with the IC₅₀ of 34.7, 5.1, and 22.4 μM respectively .

HY-N0155R

Nobiletin (Standard)	Reference Standards ROR Reactive Oxygen Species (ROS) Apoptosis Autophagy	Neurological Disease Inflammation/Immunology Cancer
Nobiletin (Standard) is the analytical standard of Nobiletin. This product is intended for research and analytical applications. Nobiletin is a poly-methoxylated flavone from the citrus peel that improves memory loss. Nobiletin is a retinoid acid receptor-related orphan receptors (RORs) agonist. Nobiletin can reduce reactive oxygen species (ROS) levels in differentiated C2C12 myotubes and has anti-inflammation and anti-cancer properties, including anti-angiogenesis, anti-proliferation, anti-metastasis and induced apoptosis .

HY-A0067R

Oxybenzone (Standard) Benzophenone 3 (Standard)	Reference Standards RAR/RXR Autophagy Apoptosis	Neurological Disease
Oxybenzone (Standard) is the analytical standard of Oxybenzone. This product is intended for research and analytical applications. Oxybenzone (Benzophenone 3) is a commonly used UV filter in sun tans and skin protectants. Oxybenzone act as endocrine disrupting chemicals (EDCs) and can pass through the placental and blood-brain barriers. Benzophenone-3 impairs autophagy, alters epigenetic status, and disrupts **retinoid X receptor** signaling in apoptotic neuronal cells .

HY-126044

6-Hydroxy bexarotene	Endogenous Metabolite	Metabolic Disease
6-Hydroxy bexarotene is the main circulating metabolite of bexarotene, found in rats, dogs, and humans. Compared to the parent compound, 6-hydroxy-bexarotene shows a significantly reduced ability to bind to retinoid receptors and exhibits very minimal activity in activating retinoic acid receptors .

HY-160212

JP3000	RAR/RXR	Metabolic Disease
JP3000, a chemical probe, is an agonist of RXRA, RXRB, RXRG .

HY-N2992

16α-Hydroxytrametenolic acid	RAR/RXR	Cancer
16α-Hydroxytrametenolic acid, a natural triterpene, is a potential retinoid X receptor (RXR) selective agonist .

HY-115879

SHR168442	ROR	Inflammation/Immunology Cancer
SHR168442 is a modulator of retinoid-related orphan receptor gamma (RORγ) with an IC₅₀ value of 0.035 μM.

HY-145590

Retezorogant	ROR	Cancer
Retezorogant is a retinoid-related orphan receptor γ (RORγ) antagonist, extracted from patent WO2016093342 A1.

HY-100008R

Peretinoin (Standard) NIK333 (Standard)	Reference Standards RAR/RXR SphK Autophagy HCV	Infection Cancer
Peretinoin (Standard) is the analytical standard of Peretinoin. This product is intended for research and analytical applications. Peretinoin is an oral acyclic retinoid with a vitamin A-like structure that targets retinoid nuclear receptors such as retinoid X receptor (RXR) and retinoic acid receptor (RAR). Peretinoin reduces the mRNA level of sphingosine kinase 1 (SPHK1) in vitro by downregulating a transcription factor, Sp1[1]. Peretinoin prevents the progression of non-alcoholic steatohepatitis (NASH) and the development of hepatocellular carcinoma (HCC) through activating the autophagy pathway by increased Atg16L1 expression[2]. Peretinoin inhibits HCV RNA amplification and virus release by altering lipid metabolism with a EC50 of 9 μM[3].

HY-15373R

Fenretinide (Standard) 4-HPR (Standard); ISLA-101 (Standard)	Reference Standards RAR/RXR Autophagy	Cancer
Fenretinide (Standard) is the analytical standard of Fenretinide. This product is intended for research and analytical applications. Fenretinide (4-HPR) is a synthetic retinoid deriverative, binding to the retinoic acid receptors (RAR) at concentrations necessary to induce cell death.

HY-175480

RXR agonist 2	RAR/RXR	Neurological Disease Metabolic Disease
RXR agonist 2 (Compound 22) is a highly selective retinoid X receptor (RXR) agonist (EC₅₀=0.039 μM). RXR agonist 2 is promising for research of metabolic syndrome and Alzheimer's disease .

HY-177890

UAB116	LXR RAR/RXR Wnt β-catenin	Cancer
UAB116 is a *Liver X Receptor* (LXR)/Retinoid X Receptor (RXR) agonist. UAB116 can decreases metastatic phenotype in hepatoblastoma by inhibiting the Wnt/β-Catenin** pathway via upregulation of TRIM29. UAB116 can reduce proliferation, stemness and invasiveness of metastatic hepatoblastoma cells .

HY-101108S

Tazarotenic acid-d6 AGN 190299-d₆	Isotope-Labeled Compounds Drug Metabolite	Others
Tazarotenic acid-d₆ is deuterium labeled Tazarotenic acid. Tazarotenic acid is the metabolite of Tazarotene. Tazarotenic acid binding to retinoic acid receptors (RARs) is the probable molecular target of retinoid action. Tazarotenic acid has the potential for the research of warty dyskeratoma .

HY-U00449S

AGN 193109-d7	Isotope-Labeled Compounds RAR/RXR	Cancer
AGN 193109-d₇ is the deuterium labeled AGN 193109. AGN 193109 is a retinoid analog, and acts as a specific and highly effective antagonist of retinoic acid receptors (RARs), with Kds of 2 nM, 2 nM, and 3 nM for RARα, RARβ, and RARγ, respectively.

HY-142936

RORγt modulator 3	ROR	Neurological Disease Inflammation/Immunology Cancer
RORγt modulator 3 (Compound 23) is a modulator of retinoid-related orphan receptor γt (RORγt). RORγt modulator 3 can be used for the research of RORyt mediated diseases such as, e.g., pain, inflammation, COPD, asthma, rheumatoid arthritis, colitis, multiple sclerosis, psoriasis, neurodegenerative diseases and cancer .

HY-117182

LG190178	Apoptosis VD/VDR RAR/RXR	Metabolic Disease Inflammation/Immunology Cancer
LG190178 is a non-steroidal vitamin D receptor (VDR) ligand that can induce the formation of heterodimer complexes between VDR and retinoid X receptor (RXR), stabilizing the agonistic conformation of the VDR ligand-binding domain and promoting its interaction with co-activators. LG190178 has functions in regulating calcium homeostasis, bone mineralization, as well as cell proliferation, differentiation, and apoptosis, making it useful for research in psoriasis, osteoporosis, and cancer .

HY-142935

RORγt modulator 2	ROR	Neurological Disease Inflammation/Immunology Cancer
RORγt modulator 2 (Compound 21) is a modulator of retinoid-related orphan receptor γt (RORγt) with the IC₅₀ of <50 nM. RORγt modulator 2 can be used for the research of RORyt mediated diseases such as, e.g., pain, inflammation, COPD, asthma, rheumatoid arthritis, colitis, multiple sclerosis, psoriasis, neurodegenerative diseases and cancer .

HY-14171S2

Bexarotene-13C6 LGD1069-¹³C₆	Isotope-Labeled Compounds RAR/RXR Autophagy	Cancer
Bexarotene- ¹³C₆ (LGD1069- ¹³C₆) is ¹³C labeled Bexarotene. Bexarotene (LGD1069) is a high-affinity and selective retinoid X receptors (RXR) agonist with EC₅₀s of 33, 24, 25 nM for RXRα, RXRβ, and RXRγ, respectively. Bexarotene shows limited affinity for RAR receptors (EC₅₀ >10000 nM) . Bexarotene can be used for the research of cutaneous T-cell lymphoma.

HY-14171R

Bexarotene (Standard) LGD1069 (Standard)	Reference Standards RAR/RXR Autophagy	Cancer
Bexarotene (Standard) is the analytical standard of Bexarotene. This product is intended for research and analytical applications. Bexarotene (LGD1069) is a high-affinity and selective retinoid X receptors (RXR) agonist with EC₅₀s of 33, 24, 25 nM for RXRα, RXRβ, and RXRγ, respectively. Bexarotene shows limited affinity for RAR receptors (EC₅₀ >10000 nM) . Bexarotene can be used for the research of cutaneous T-cell lymphoma.

HY-101108R

Tazarotenic acid (Standard) AGN 190299 (Standard)	Reference Standards Drug Metabolite	Others
Deoxycholic acid (Standard) is the analytical standard of Deoxycholic acid. This product is intended for research and analytical applications. Deoxycholic acid (cholanoic acid), a bile acid, is a by-product of intestinal metabolism, that activates the G protein-coupled bile acid receptorTGR5 .

HY-W777169

Bexarotene-13C4 LGD1069-¹³C₄	Isotope-Labeled Compounds RAR/RXR Autophagy	Cancer
Bexarotene- ¹³C₄ (LGD1069- ¹³C₄) is the ¹³C-labeled Bexarotene (HY-14171). Bexarotene (LGD1069) is a high-affinity and selective retinoid X receptors (RXR) agonist with EC₅₀s of 33, 24, 25 nM for RXRα, RXRβ, and RXRγ, respectively. Bexarotene shows limited affinity for RAR receptors (EC₅₀ >10000 nM) . Bexarotene can be used for the research of cutaneous T-cell lymphoma.

HY-U00449R

AGN 193109 (Standard)	Reference Standards RAR/RXR	Cancer
AGN 193109 is a retinoid analog, and acts as a specific and highly effective antagonist of retinoic acid receptors (RARs), with Kds of 2 nM, 2 nM, and 3 nM for RARα, RARβ, and RARγ, respectively. AGN 193109 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. AGN 193109 is the antidote for retinoic acidosis, that ameliorates the skin and mucosal toxicity.

HY-101108S1

Tazarotenic acid-13C2,d2 AGN 190299-¹³C₂,d₂	Drug Metabolite Isotope-Labeled Compounds	Others
Tazarotenic acid-13C2,d2 (AGN 190299-13C2,d2) is the ¹³C and deuterium labeled isotope of Tazarotenic acid (HY-101108). Tazarotenic acid is the metabolite of Tazarotene. Tazarotenic acid binding to retinoic acid receptors (RARs) is the probable molecular target of retinoid action. Tazarotenic acid has the potential for the research of warty dyskeratoma .

HY-A0067S1

Oxybenzone-13C6 Benzophenone 3-13C₆	Isotope-Labeled Compounds RAR/RXR Autophagy Apoptosis	Neurological Disease
Oxybenzone- ¹³C₆ (Benzophenone 3- ¹³C₆) is the ¹³C-labeled Oxybenzone (HY-A0067). Oxybenzone (Benzophenone 3) is a commonly used UV filter in sun tans and skin protectants. Oxybenzone act as endocrine disrupting chemicals (EDCs) and can pass through the placental and blood-brain barriers. Benzophenone-3 impairs autophagy, alters epigenetic status, and disrupts retinoid X receptor signaling in apoptotic neuronal cells .

Cat. No.	Nombre del producto	Type

HY-107413G

SR11237

Fluorescent Dyes

SR11237 GMP is SR11237 (HY-107413) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. SR11237 is a RXR activator and lipid metabolism regulator that promotes the differentiation of induced neural stem cells into dopaminergic (TH-positive) neurons. SR11237 induces transcriptional regulation of lipogenic genes and cholesterol transporters, increases glycosaminoglycan release, and elevates total cellular triglyceride levels. SR11237 promotes heterodimerization of RXR with Nurr1, thereby enhancing tyrosine hydroxylase expression and facilitating dopamine release. SR11237 produces a synergistic effect when used in combination with bFGF/EGF. SR11237 is mainly used in studies related to osteoarthritis and Parkinson's disease .

Cat. No.	Nombre del producto	Type

HY-107413G

SR11237

Biochemical Assay Reagents

Cat. No.	Nombre del producto	Category	Target	Chemical Structure

HY-N0155

Nobiletin 25+ Cited Publications	Flavonoids Neurological Disease Classification of Application Fields Flavones Rutaceae Plants Inflammation/Immunology Disease Research Fields Citrus reticulata Blanco Source Classification	ROR Reactive Oxygen Species (ROS) Apoptosis Autophagy
Nobiletin is a poly-methoxylated flavone from the citrus peel that improves memory loss. Nobiletin is a retinoid acid receptor-related orphan receptors (RORs) agonist. Nobiletin can reduce reactive oxygen species (ROS) levels in differentiated C2C12 myotubes and has anti-inflammation and anti-cancer properties, including anti-angiogenesis, anti-proliferation, anti-metastasis and induced apoptosis .

HY-32350

Ercalcitriol 3 Publications Verification 1α,25-Dihydroxy Vitamin D2	Productos naturales Classification of Application Fields Metabolic Disease Endogenous metabolite Disease Research Fields Source Classification	VD/VDR Drug Metabolite Endogenous Metabolite
Ercalcitriol (1α,25-Dihydroxy Vitamin D2) is a *vitamin D receptor* (VDR)** agonist with high binding affinity. After binding to VDR, Ercalcitriol forms a complex with retinoid X receptor (RXR) to regulate target gene transcription. For example, Ercalcitriol induces human gingival/oral epithelial cells to produce human cat antimicrobial peptide (hCAP-18/LL-37), which has antimicrobial activity against periodontal pathogens such as Porphyromonas gingivalis. Ercalcitriol enhances the innate immune defense of the oral mucosa by promoting the expression of antimicrobial peptides, and is mainly used in the study of periodontal diseases and immune-related oral diseases .

HY-116506

Bigelovin	Classification of Application Fields Ketones, Aldehydes, Acids Acacia auriculiformis A.Cunn. ex Benth Plants Compositae Disease Research Fields Cancer	RAR/RXR Reactive Oxygen Species (ROS) Apoptosis Autophagy
Bigelovin, a sesquiterpene lactone isolated from Inula hupehensis, is a selective retinoid X receptor α agonist. Bigelovin suppresses tumor growth through inducing apoptosis and autophagy via the inhibition of mTOR pathway regulated by ROS generation .

HY-W107616

3,7,11,15-Tetramethyl-2-hexadecen-1-ol	Productos naturales Rudbeckia laciniata L. Plants Compositae Source Classification	Endogenous Metabolite
3,7,11,15-Tetramethyl-2-hexadecen-1-ol can be used to synthesize vitamin E and vitamin E's precursor vitamin K1. 3,7,11,15-Tetramethyl-2-hexadecen-1-ol regulates transcription in cells through the transcription factor PPAR-alpha and the retinoid X receptor (RXR)43 .

HY-N0155R

Nobiletin (Standard)	Structural Classification Flavonoids Flavones Rutaceae Plants Citrus reticulata Blanco Source Classification	Reference Standards ROR Reactive Oxygen Species (ROS) Apoptosis Autophagy
Nobiletin (Standard) is the analytical standard of Nobiletin. This product is intended for research and analytical applications. Nobiletin is a poly-methoxylated flavone from the citrus peel that improves memory loss. Nobiletin is a retinoid acid receptor-related orphan receptors (RORs) agonist. Nobiletin can reduce reactive oxygen species (ROS) levels in differentiated C2C12 myotubes and has anti-inflammation and anti-cancer properties, including anti-angiogenesis, anti-proliferation, anti-metastasis and induced apoptosis .

HY-N2992

16α-Hydroxytrametenolic acid	Other Terpenoids Classification of Application Fields Terpenoids Polyporaceae Poria cocos Plants Disease Research Fields Cancer Source Classification	RAR/RXR
16α-Hydroxytrametenolic acid, a natural triterpene, is a potential retinoid X receptor (RXR) selective agonist .

HY-N19756

Cochinchinone P	Structural Classification Flavonoids Cratoxylum cochinchinense (Lour.) Blume Hypericaceae Plants Other Flavonoids Source Classification	RAR/RXR
Cochinchinone P is a retinoid X receptor-α (RXRα) inhibitor that inhibits 9-cis-retinoic acid (HY-15128)-induced transcriptional activity of RXRα in vitro. Cochinchinone P can be used in cancer research .

HY-W107616R

3,7,11,15-Tetramethyl-2-hexadecen-1-ol (Standard)	Structural Classification Productos naturales Rudbeckia laciniata L. Plants Compositae Source Classification	Endogenous Metabolite Reference Standards
3,7,11,15-Tetramethyl-2-hexadecen-1-ol (Standard) is the analytical standard of 3,7,11,15-Tetramethyl-2-hexadecen-1-ol (HY-W107616). This product is intended for research and analytical applications. 3,7,11,15-Tetramethyl-2-hexadecen-1-ol can be used to synthesize vitamin E and vitamin E's precursor vitamin K1. 3,7,11,15-Tetramethyl-2-hexadecen-1-ol regulates transcription in cells through the transcription factor PPAR-alpha and the retinoid X receptor (RXR)43 .

Cat. No.	Nombre del producto	Chemical Structure

HY-14171S

Bexarotene-d4
Bexarotene-d₄ is a deuterium labeled Bexarotene (LGD1069). Bexarotene (LGD1069) is a selective retinoid X receptors (RXR) agonist for the treatment of cutaneous T-cell lymphoma .

HY-A0067S

Oxybenzone-d5
Oxybenzone-d₅ is the deuterium labeled Oxybenzone . Oxybenzone (Benzophenone 3) is a commonly used UV filter in sun tans and skin protectants. Oxybenzone act as endocrine disrupting chemicals (EDCs) and can pass through the placental and blood-brain barriers. Benzophenone-3 impairs autophagy, alters epigenetic status, and disrupts retinoid X receptor signaling in apoptotic neuronal cells .

HY-101108S

Tazarotenic acid-d6
Tazarotenic acid-d₆ is deuterium labeled Tazarotenic acid. Tazarotenic acid is the metabolite of Tazarotene. Tazarotenic acid binding to retinoic acid receptors (RARs) is the probable molecular target of retinoid action. Tazarotenic acid has the potential for the research of warty dyskeratoma .

HY-U00449S

AGN 193109-d7
AGN 193109-d₇ is the deuterium labeled AGN 193109. AGN 193109 is a retinoid analog, and acts as a specific and highly effective antagonist of retinoic acid receptors (RARs), with Kds of 2 nM, 2 nM, and 3 nM for RARα, RARβ, and RARγ, respectively.

HY-14171S2

Bexarotene-13C6

Bexarotene- ¹³C₆ (LGD1069- ¹³C₆) is ¹³C labeled Bexarotene. Bexarotene (LGD1069) is a high-affinity and selective retinoid X receptors (RXR) agonist with EC₅₀s of 33, 24, 25 nM for RXRα, RXRβ, and RXRγ, respectively. Bexarotene shows limited affinity for RAR receptors (EC₅₀ >10000 nM) . Bexarotene can be used for the research of cutaneous T-cell lymphoma.

HY-W777169

Bexarotene-13C4
Bexarotene- ¹³C₄ (LGD1069- ¹³C₄) is the ¹³C-labeled Bexarotene (HY-14171). Bexarotene (LGD1069) is a high-affinity and selective retinoid X receptors (RXR) agonist with EC₅₀s of 33, 24, 25 nM for RXRα, RXRβ, and RXRγ, respectively. Bexarotene shows limited affinity for RAR receptors (EC₅₀ >10000 nM) . Bexarotene can be used for the research of cutaneous T-cell lymphoma.

HY-101108S1

Tazarotenic acid-13C2,d2
Tazarotenic acid-13C2,d2 (AGN 190299-13C2,d2) is the ¹³C and deuterium labeled isotope of Tazarotenic acid (HY-101108). Tazarotenic acid is the metabolite of Tazarotene. Tazarotenic acid binding to retinoic acid receptors (RARs) is the probable molecular target of retinoid action. Tazarotenic acid has the potential for the research of warty dyskeratoma .

HY-A0067S1

Oxybenzone-13C6

Oxybenzone- ¹³C₆ (Benzophenone 3- ¹³C₆) is the ¹³C-labeled Oxybenzone (HY-A0067). Oxybenzone (Benzophenone 3) is a commonly used UV filter in sun tans and skin protectants. Oxybenzone act as endocrine disrupting chemicals (EDCs) and can pass through the placental and blood-brain barriers. Benzophenone-3 impairs autophagy, alters epigenetic status, and disrupts retinoid X receptor signaling in apoptotic neuronal cells .

HY-W653958

Oxybenzone-d3

Oxybenzone-d₃ (Benzophenone 3-d₃) is a deuterium labeled Oxybenzone (HY-A0067). Oxybenzone (Benzophenone 3) is a commonly used UV filter in sun tans and skin protectants. Oxybenzone act as endocrine disrupting chemicals (EDCs) and can pass through the placental and blood-brain barriers. Benzophenone-3 impairs autophagy, alters epigenetic status, and disrupts retinoid X receptor signaling in apoptotic neuronal cells .

HY-32350S1

Ercalcitriol-d3

Ercalcitriol-d₃ (1α,25-Dihydroxy Vitamin D2-d₃) is the deuterium labeled Ercalcitriol (HY-32350). Ercalcitriol (1α,25-Dihydroxy Vitamin D2) is a vitamin D receptor (VDR) agonist with high binding affinity. After binding to VDR, Ercalcitriol forms a complex with retinoid X receptor (RXR) to regulate target gene transcription. For example, Ercalcitriol induces human gingival/oral epithelial cells to produce human cat antimicrobial peptide (hCAP-18/LL-37), which has antimicrobial activity against periodontal pathogens such as Porphyromonas gingivalis. Ercalcitriol enhances the innate immune defense of the oral mucosa by promoting the expression of antimicrobial peptides, and is mainly used in the study of periodontal diseases and immune-related oral diseases .

Targets Recommended: RAR/RXR

Cat. No.	Nombre del producto	Target	Áreas de investigación	Chemical Structure

HY-107413G

SR11237	RAR/RXR Tyrosine Hydroxylase	Neurological Disease Inflammation/Immunology
SR11237 GMP is SR11237 (HY-107413) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. SR11237 is a RXR activator and lipid metabolism regulator that promotes the differentiation of induced neural stem cells into dopaminergic (TH-positive) neurons. SR11237 induces transcriptional regulation of lipogenic genes and cholesterol transporters, increases glycosaminoglycan release, and elevates total cellular triglyceride levels. SR11237 promotes heterodimerization of RXR with Nurr1, thereby enhancing tyrosine hydroxylase expression and facilitating dopamine release. SR11237 produces a synergistic effect when used in combination with bFGF/EGF. SR11237 is mainly used in studies related to osteoarthritis and Parkinson's disease .

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