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vascular endothelial cadherin

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By Targets:	Cadherin (3) Akt (3) Apoptosis (1) Claudin (2) GSK-3 (1) MDM-2/p53 (1) MMP (1) mTOR (1) OGT (1) PARP (1) PI3K (2) Reactive Oxygen Species (ROS) (1) Tie (2)
By Research Areas:	Cancer (1) Cardiovascular Disease (3) Infection (2) Inflammation/Immunology (3) Neurological Disease (1)

4

Inhibitors & Agonists

3

Peptides

1

Natural
Products

3

Recombinant Proteins

3

Antibodies

Targets Recommended: VEGFR Cadherin VAP-1

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

Murine Fibrinogen	MMP Cadherin	Cardiovascular Disease Neurological Disease
Murine Fibrinogen is a native fibrinogen derived from mouse plasma. Murine Fibrinogen acts as a cerebrovascular permeability enhancer. Murine Fibrinogen activates matrix metalloproteinase-9 (MMP-9), downregulates the expression of vascular endothelial cadherin (VE-cadherin), and upregulates the expression of plasmalemmal vesicle-associated protein-1 (PV-1). Murine Fibrinogen increases macromolecular leakage from pial veins, thereby disrupting the microvascular integrity of cerebral blood vessels. Murine Fibrinogen can be used in studies related to cerebrovascular dysfunction .

Dammarenediol II	OGT Akt mTOR GSK-3 Reactive Oxygen Species (ROS) Apoptosis PARP MDM-2/p53	Inflammation/Immunology Cancer
Dammarenediol II is a ginsenoside precursor . Dammarenediol II reduces the activity of O-GlcNAc transferase (OGT) and downregulates the global O-GlcNAcylation level. Dammarenediol II inhibits the phosphorylation of Akt, mTOR and GSK3β. Dammarenediol II inhibits human carboxylesterase activity, VEGF-induced ROS production, stress fiber formation and vascular endothelial cadherin disruption. Dammarenediol II promotes cell apoptosis (apoptosis), increases the levels of cleaved PARP1 and p53, and inhibits retinal microvascular leakage. Dammarenediol II can be used in studies related to liver cancer and diabetic retinopathy .

Vasculotide	Tie PI3K Akt Cadherin Claudin	Cardiovascular Disease Infection Inflammation/Immunology
Vasculotide is a blood-brain barrier (BBB)-penetrant Tie2 agonist. Vasculotide binds to a unique domain of Tie2, induces receptor clustering to drive phosphorylation, activates downstream PI3K/Akt and eNOS pathways, enhances inter-endothelial cell junctions (such as *VE-cadherin* and claudin-5), and inhibits inflammatory adhesion molecules, ultimately stabilizing the vascular endothelial barrier and reducing its permeability . Vasculotide alleviates pulmonary microvascular leakage and microcirculatory dysfunction caused by cardiopulmonary bypass, acts as an adjuvant radioprotective agent to reduce acute radiation dermatitis, and promotes BBB recovery after focused ultrasound (FUS). Combination of Vasculotide with antibiotics reduces lung injury .

Vasculotide TFA	Cadherin Tie Claudin PI3K Akt	Cardiovascular Disease Infection Inflammation/Immunology
Vasculotide TFA is a blood-brain barrier (BBB)-penetrant Tie2 agonist. Vasculotide TFA binds to a unique domain of Tie2, induces receptor clustering to drive phosphorylation, activates downstream PI3K/Akt and eNOS pathways, enhances inter-endothelial cell junctions (such as *VE-cadherin* and claudin-5), and inhibits inflammatory adhesion molecules, ultimately stabilizing the vascular endothelial barrier and reducing its permeability . Vasculotide TFA alleviates pulmonary microvascular leakage and microcirculatory dysfunction caused by cardiopulmonary bypass, acts as an adjuvant radioprotective agent to reduce acute radiation dermatitis, and promotes BBB recovery after focused ultrasound (FUS). Combination of Vasculotide TFA with antibiotics reduces lung injury .

Cat. No.	Product Name	Target	Research Area

Vasculotide	Tie PI3K Akt Cadherin Claudin	Cardiovascular Disease Infection Inflammation/Immunology
Vasculotide is a blood-brain barrier (BBB)-penetrant Tie2 agonist. Vasculotide binds to a unique domain of Tie2, induces receptor clustering to drive phosphorylation, activates downstream PI3K/Akt and eNOS pathways, enhances inter-endothelial cell junctions (such as *VE-cadherin* and claudin-5), and inhibits inflammatory adhesion molecules, ultimately stabilizing the vascular endothelial barrier and reducing its permeability . Vasculotide alleviates pulmonary microvascular leakage and microcirculatory dysfunction caused by cardiopulmonary bypass, acts as an adjuvant radioprotective agent to reduce acute radiation dermatitis, and promotes BBB recovery after focused ultrasound (FUS). Combination of Vasculotide with antibiotics reduces lung injury .

pVEC (Cadherin-5)	Peptides	Others
pVEC (Cadherin-5) is a cell-penetrating 18-amino acid-long peptide derived from the murine sequence of the cell adhesion molecule vascular endothelial cadherin. pVEC (Cadherin-5) is efficiently and rapidly taken up into cells, it can be used as a carrier peptide .

Vasculotide TFA	Cadherin Tie Claudin PI3K Akt	Cardiovascular Disease Infection Inflammation/Immunology
Vasculotide TFA is a blood-brain barrier (BBB)-penetrant Tie2 agonist. Vasculotide TFA binds to a unique domain of Tie2, induces receptor clustering to drive phosphorylation, activates downstream PI3K/Akt and eNOS pathways, enhances inter-endothelial cell junctions (such as *VE-cadherin* and claudin-5), and inhibits inflammatory adhesion molecules, ultimately stabilizing the vascular endothelial barrier and reducing its permeability . Vasculotide TFA alleviates pulmonary microvascular leakage and microcirculatory dysfunction caused by cardiopulmonary bypass, acts as an adjuvant radioprotective agent to reduce acute radiation dermatitis, and promotes BBB recovery after focused ultrasound (FUS). Combination of Vasculotide TFA with antibiotics reduces lung injury .

Cat. No.	Product Name	Category	Target	Chemical Structure

Dammarenediol II	Triterpenes Structural Classification other families Boswellia freerana Terpenoids Plants Source Classification	OGT Akt mTOR GSK-3 Reactive Oxygen Species (ROS) Apoptosis PARP MDM-2/p53
Dammarenediol II is a ginsenoside precursor . Dammarenediol II reduces the activity of O-GlcNAc transferase (OGT) and downregulates the global O-GlcNAcylation level. Dammarenediol II inhibits the phosphorylation of Akt, mTOR and GSK3β. Dammarenediol II inhibits human carboxylesterase activity, VEGF-induced ROS production, stress fiber formation and vascular endothelial cadherin disruption. Dammarenediol II promotes cell apoptosis (apoptosis), increases the levels of cleaved PARP1 and p53, and inhibits retinal microvascular leakage. Dammarenediol II can be used in studies related to liver cancer and diabetic retinopathy .

Species:	Human (1) Mouse (1) Rat (1)
Tag:	His (3) Fc (1)
Source:	HEK293 (3)

Cat. No.	Compare	Product Name	Species	Source	Image

	VE-Cadherin Protein, Rat (HEK293, His) cadherin-5; VE-cadherin; CD144; CDH5	Rat	HEK293
	VE-cadherin is critical for cellular functions such as β-catenin binding and signaling receptor activity, and is involved in processes such as cell-cell junction organization and vascular maturation. It is predicted to localize in cell-cell junctions and nuclei, serving as a biomarker for pulmonary hypertension. VE-Cadherin Protein, Rat (HEK293, His) is the recombinant rat-derived VE-Cadherin protein, expressed by HEK293 , with C-His labeled tag.

	VE-Cadherin Protein, Mouse (HEK293, His) cadherin-5; VE-cadherin; CD144; CDH5	Mouse	HEK293
	VE-cadherin is a calcium-dependent glycoprotein critical for mediating cell adhesion and coordinating morphogenetic events during development. Lack of VE-cadherin in mice leads to uterine death due to increased endothelial cell apoptosis leading to vascular insufficiency. VE-Cadherin Protein, Mouse (HEK293, His) is the recombinant mouse-derived VE-Cadherin protein, expressed by HEK293 , with C-10*His labeled tag.

	VE-Cadherin Protein, Human (HEK293, His-Fc) cadherin-5; VE-cadherin; CD144; CDH5	Human	HEK293
	The FGFR-4 protein binds to its ligands and activates signaling pathways involved in cell growth, differentiation, and survival. It plays a role in various developmental processes, including skeletal development, liver metabolism, and cancer progression. In the absence of ligand binding, FGFR-4 remains inactive and does not initiate downstream signaling cascades. VE-Cadherin Protein, Human (HEK293, His-Fc) is the recombinant human-derived VE-Cadherin protein, expressed by HEK293 , with C-hFc, C-6*His labeled tag.

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Host:	Mouse (1) Rabbit (2)
Reactivity:	Human (2) Rat (2) Mouse (2)
Application:	IHC-P (2) ICC/IF (3) IP (1) WB (2) FC (1) ELISA (1)
Isotype:	IgG (2)
Conjugation:	Non-conjugated (3)
Clonality:	Monoclonal (3) Recombinant (1)
Modification:	Unmodified (3)

Cat. No.	Compare	Product Name	Application	Reactivity	Image

	VE-Cadherin Antibody (YA5468) cadherin-5; 7B4 antigen; vascular endothelial cadherin; VE-cadherin; CD antigen CD144;	IHC-P, ICC/IF	Human, Mouse, Rat
	VE-Cadherin Antibody (YA5468) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to VE-Cadherin.

	VE Cadherin Antibody (YA6053) CDH5; cadherin-5; 7B4 antigen; vascular endothelial cadherin; VE-cadherin; CD antigen CD144	WB, IHC-P, ICC/IF, IP, ELISA	Mouse, Rat
	VE Cadherin Antibody (YA6053) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to VE Cadherin.

	VE-Cadherin Antibody (YA3491) 2 Publications Verification VE-cadherin; 7B4 antigen; VECD; vascular endothelial cell cadherin; 7B 4; 7B4; 7B4 antigen; cadherin 5; cadherin 5 type 2; cadherin-5; cadherin5; CD 144; CD144 antigen; CDH 5; CDH5; CDH5 protein; vascular endothelial cadherin; VE Cad antibody VEC; CADH5_HUMAN.	WB, ICC/IF, FC	Human
	VE-Cadherin Antibody (YA3491) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to VE-Cadherin.

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