sEH inhibitor-20
sEH inhibitor-20 is an orally active and metabolically stable sEH inhibitor (IC50: 0.2 nM). sEH inhibitor-20 has significant analgesic and anti-inflammatory activities and is expected to become a potential candidate compound for the study of neuropathic pain.
For research use only. We do not sell to patients.
- Formula: C19H15F3N4O3
- Molecular Weight:404.34
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
sEH inhibitor-20 (Compound FP9) (0.1 μM, 1 h) shows excellent metabolic stability (t₁/₂ > 184 min) in human and mouse liver microsomes, indicating that it is not easily metabolized by the liver in vivo[1].
sEH inhibitor-20 (10 μM, 16 h) shows moderate brain permeability in the PAMPA-BBB model (Pe : 3.83 × 10⁻⁶ cm/s)[1].
sEH inhibitor-20 (1-1000 nM, pre-treat for 0.5 h, then treat for 6 h) significantly reduces TNF-α and IL-6 levels in the LPS-induced PBMC inflammation model without cytotoxicity (10 μM still does not affect cell survival)[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:C57BL/6 mice (male, aged 6-8 weeks) intraperitoneally injected with Paclitaxel (5 mg/mL)[1]
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Dosage:10, 30 mg/kg
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Administration:acute : p.o. one dose; chronic : p.o. once a day for 14 consecutive days
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Result:Exhibited its maximum acute analgesic effect at 2 hours post-administration (30 mg/kg), with the effect persisting for 4 hours, demonstrating both longer duration and superior efficacy compared to gabapentin.
Maintained stable chronic analgesic effects at 30 mg/kg without inducing tolerance.
Chemical Information
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Molecular Weight 404.34
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Formula C19H15F3N4O3
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SMILES
O=C1NN=C(C2=CC=C(NC(NCC3=CC=CC=C3OC(F)(F)F)=O)C=C2)C=C1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
sEH inhibitor-20 Related Classifications
HY-173302 Related Classifications
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