SfUAP-IN-1
SfUAP-IN-1 is an inhibitor of SfUAP (UDP-N-acetylglucosamine pyrophosphorylase from Spodoptera frugiperda) with an IC50 value of 108 nM. As a growth and development inhibitor, SfUAP-IN-1 impairs larval growth and development of Plutella xylostella (diamondback moth), Spodoptera frugiperda (fall armyworm) and Spodoptera litura (tobacco cutworm). SfUAP-IN-1 can be used in research on green pesticides targeting insect UAP.
For research use only. We do not sell to patients.
- CAS No.: 3118855-92-5
- Formula: C24H18N2O4
- Molecular Weight:398.41
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
In Vitro
SfUAP-IN-1 (A15) (0.10-10.0 μM; 10-60 min) potently inhibits purified Sf UAP with an IC50 of 108 nM after 15 min, and exhibits time-dependent covalent inhibition with an IC50 reduced to 13.0 nM after 60 min incubation[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
In Vivo
SfUAP-IN-1 (500 μg/mL; oral administration; ad libitum feeding; 7 days) reduces the body weight of 3rd-instar Spodoptera frugiperda larvae fed on treated leaf discs ad libitum for 7 days to 61.0% of that of the control group[1].
SfUAP-IN-1 (500 μg/mL; oral administration; ad libitum feeding; 7 days) reduces the body weight of 3rd-instar Spodoptera litura larvae to 56.9% of that of the control group after 7 days of ad libitum feeding on treated leaf discs[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:third-instar Plutella xylostella larvae[1]
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Dosage:500 μg/mL
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Administration:oral (treated cabbage leaf discs); ad libitum; 7 days
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Result:Caused 63.3% mortality of larvae after 72 hours.
Reduced body weights of surviving larvae to 51.9% of the control group's body weights after 7 days.
Induced significantly reduced body lengths relative to controls after 7 days.
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Animal Model:3rd-instar Spodoptera frugiperda larvae[1]
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Dosage:500 μg/mL
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Administration:oral (treated leaf discs); ad libitum; 7 days
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Result:Reduced body weights of surviving larvae to 61.0% of the control group's body weights after 7 days.
Induced significantly reduced body lengths relative to controls after 7 days.\nReduced body weights of surviving larvae to 56.9% of the control group's body weights after 7 days.
Induced significantly reduced body lengths relative to controls after 7 days.
Chemical Information
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CAS No. 3118855-92-5
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Molecular Weight 398.41
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Formula C24H18N2O4
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SMILES
O=C(NC1=CC=C(OC2=CC=CC=C2)C=C1)CC3=CC=C(N4C(C=CC4=O)=O)C=C3
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocols
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Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
SfUAP-IN-1 Related Classifications
HY-183675 Related Classifications
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