SfUAP-IN-1
SfUAP-IN-1 is an inhibitor of SfUAP (UDP-N-acetylglucosamine pyrophosphorylase from Spodoptera frugiperda) with an IC50 value of 108 nM. As a growth and development inhibitor, SfUAP-IN-1 impairs larval growth and development of Plutella xylostella (diamondback moth), Spodoptera frugiperda (fall armyworm) and Spodoptera litura (tobacco cutworm). SfUAP-IN-1 can be used in research on green pesticides targeting insect UAP.
For research use only. We do not sell to patients.
- CAS No.: 3118855-92-5
- Formula: C24H18N2O4
- Molecular Weight:398.41
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
-
Biological Activity
-
Chemical Information
- Purity & Documentation
- References
-
Help & FAQs
Biological Activity
SfUAP-IN-1 (A15) (0.10-10.0 μM; 10-60 min) potently inhibits purified Sf UAP with an IC50 of 108 nM after 15 min, and exhibits time-dependent covalent inhibition with an IC50 reduced to 13.0 nM after 60 min incubation[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
SfUAP-IN-1 (500 μg/mL; oral administration; ad libitum feeding; 7 days) reduces the body weight of 3rd-instar Spodoptera frugiperda larvae fed on treated leaf discs ad libitum for 7 days to 61.0% of that of the control group[1].
SfUAP-IN-1 (500 μg/mL; oral administration; ad libitum feeding; 7 days) reduces the body weight of 3rd-instar Spodoptera litura larvae to 56.9% of that of the control group after 7 days of ad libitum feeding on treated leaf discs[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Animal Model:third-instar Plutella xylostella larvae[1]
-
Dosage:500 μg/mL
-
Administration:oral (treated cabbage leaf discs); ad libitum; 7 days
-
Result:Caused 63.3% mortality of larvae after 72 hours.
Reduced body weights of surviving larvae to 51.9% of the control group's body weights after 7 days.
Induced significantly reduced body lengths relative to controls after 7 days.
-
Animal Model:3rd-instar Spodoptera frugiperda larvae[1]
-
Dosage:500 μg/mL
-
Administration:oral (treated leaf discs); ad libitum; 7 days
-
Result:Reduced body weights of surviving larvae to 61.0% of the control group's body weights after 7 days.
Induced significantly reduced body lengths relative to controls after 7 days.\nReduced body weights of surviving larvae to 56.9% of the control group's body weights after 7 days.
Induced significantly reduced body lengths relative to controls after 7 days.
Chemical Information
-
CAS No. 3118855-92-5
-
Molecular Weight 398.41
-
Formula C24H18N2O4
-
SMILES
O=C(NC1=CC=C(OC2=CC=CC=C2)C=C1)CC3=CC=C(N4C(C=CC4=O)=O)C=C3
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Powered by Bioz