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  4. SfUAP-IN-1

SfUAP-IN-1 is an inhibitor of SfUAP (UDP-N-acetylglucosamine pyrophosphorylase from Spodoptera frugiperda) with an IC50 value of 108 nM. As a growth and development inhibitor, SfUAP-IN-1 impairs larval growth and development of Plutella xylostella (diamondback moth), Spodoptera frugiperda (fall armyworm) and Spodoptera litura (tobacco cutworm). SfUAP-IN-1 can be used in research on green pesticides targeting insect UAP.

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SfUAP-IN-1

SfUAP-IN-1 Chemical Structure

CAS No. : 3118855-92-5

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SfUAP-IN-1 Related Antibodies

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Description

SfUAP-IN-1 is an inhibitor of SfUAP (UDP-N-acetylglucosamine pyrophosphorylase from Spodoptera frugiperda) with an IC50 value of 108 nM. As a growth and development inhibitor, SfUAP-IN-1 impairs larval growth and development of Plutella xylostella (diamondback moth), Spodoptera frugiperda (fall armyworm) and Spodoptera litura (tobacco cutworm). SfUAP-IN-1 can be used in research on green pesticides targeting insect UAP[1].

In Vitro

SfUAP-IN-1 (A15) (0.10-10.0 μM; 10-60 min) potently inhibits purified Sf UAP with an IC50 of 108 nM after 15 min, and exhibits time-dependent covalent inhibition with an IC50 reduced to 13.0 nM after 60 min incubation[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

SfUAP-IN-1 Related Antibodies
In Vivo

SfUAP-IN-1 (500 μg/mL; oral administration; ad libitum feeding; 7 days) results in a mortality rate of 63.3% in third-instar Plutella xylostella larvae at 72 hours post-treatment; after 7 days of feeding, the larval body weight decreases to 51.9% of that in the control group[1].
SfUAP-IN-1 (500 μg/mL; oral administration; ad libitum feeding; 7 days) reduces the body weight of 3rd-instar Spodoptera frugiperda larvae fed on treated leaf discs ad libitum for 7 days to 61.0% of that of the control group[1].
SfUAP-IN-1 (500 μg/mL; oral administration; ad libitum feeding; 7 days) reduces the body weight of 3rd-instar Spodoptera litura larvae to 56.9% of that of the control group after 7 days of ad libitum feeding on treated leaf discs[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: third-instar Plutella xylostella larvae[1]
Dosage: 500 μg/mL
Administration: oral (treated cabbage leaf discs); ad libitum; 7 days
Result: Caused 63.3% mortality of larvae after 72 hours.
Reduced body weights of surviving larvae to 51.9% of the control group's body weights after 7 days.
Induced significantly reduced body lengths relative to controls after 7 days.
Animal Model: 3rd-instar Spodoptera frugiperda larvae[1]
Dosage: 500 μg/mL
Administration: oral (treated leaf discs); ad libitum; 7 days
Result: Reduced body weights of surviving larvae to 61.0% of the control group's body weights after 7 days.
Induced significantly reduced body lengths relative to controls after 7 days.\nReduced body weights of surviving larvae to 56.9% of the control group's body weights after 7 days.
Induced significantly reduced body lengths relative to controls after 7 days.
Molecular Weight

398.41

Formula

C24H18N2O4
CAS No.
SMILES

O=C(NC1=CC=C(OC2=CC=CC=C2)C=C1)CC3=CC=C(N4C(C=CC4=O)=O)C=C3
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Purity & Documentation
References
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SfUAP-IN-1 Related Classifications

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Keywords:

SfUAP-IN-13118855-92-5InsecticideSpodoptera frugiperda UDP-N-acetylglucosamine pyrophosphorylasesulfhydryl groupsSf UAPGSHmaleimide warheadgreen pesticidesSpodoptera lituraPlutella xylostellamolecular dynamics simulationsSpodoptera frugiperdaInhibitorinhibitorinhibit

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