TPBG - trophoblast glycoprotein Gene
Also Known as 5T4; M6P1; 5T4AG; WAIF1
Species: Homo sapiens
About TPBG
This gene has 3 transcripts (splice variants), 1 gene allele and 185 orthologues. Ubiquitous expression in esophagus (RPKM 8.0), endometrium (RPKM 5.0) and 22 other tissues.
Summary
This gene encodes a leucine-rich Transmembrane Glycoprotein that may be involved in cell adhesion. The encoded protein is an oncofetal antigen that is specific to trophoblast cells. In adults this protein is highly expressed in many tumor cells and is associated with poor clinical outcome in numerous cancers. Alternate splicing in the 5' UTR results in multiple transcript variants that encode the same protein. [provided by RefSeq, Oct 2009]
TPBG Products (3)
| mRNA | Protein | Name |
|---|---|---|
| NM_001166392.2 | NP_001159864.1 | trophoblast glycoprotein precursor |
| NM_001376922.1 | NP_001363851.1 | trophoblast glycoprotein precursor |
| NM_006670.5 | NP_006661.1 | trophoblast glycoprotein precursor |
TPBG Protein Structure
LRRNT: Leucine rich repeat N-terminal domain (61 - 90)
LRR_8: Leucine rich repeat (93 - 154)
LRR_8: Leucine rich repeat (211 - 270)
LRRCT: Leucine rich repeat C-terminal domain (321 - 345)
- 0
- 100
- 200
- 300
- 400
- 420 a.a.
| Protein Preferred Names | Protein Names | |
|---|---|---|
|
trophoblast glycoprotein |
|
Recombinant TPBG Proteins
| Cat. No. | Product Name | Accession | Purity |
|---|---|---|---|
| HY-P70512 | TPBG/5T4 Protein, Human (HEK293, His) | Q13641 (S32-S355) | ≥ 95%, as determined by reducing SDS-PAGE. |
| HY-P71374 | TPBG/5T4 Protein, Human (HEK293, mFc) | Q13641 (S32-S355) | ≥ 95%, as determined by reducing SDS-PAGE. |
| HY-P72421 | TPBG/5T4 Protein, Human (HEK293, Avi-His) | Q13641 (S32-S355) | ≥ 95%, as determined by reducing SDS-PAGE. |
| HY-P78053 | TPBG/5T4 Protein, Human (Biotinylated, HEK293, His-Avi) | Q13641 (S32-S355) | ≥ 95%, as determined by Bis-Tris PAGE. |
| HY-P700840 | FITC-Labeled TPBG/5T4 Protein, Human (HEK293, His-Avi) | Q13641-1 (S32-S355) | ≥ 95%, as determined by reducing SDS-PAGE. |
| HY-P701049 | TPBG/5T4 Protein, Human (HEK293, hFc) | Q13641 (S32-S355) | ≥ 95%, as determined by reducing SDS-PAGE. |
TPBG Antibodies
| Cat. No. | Product Name | Application | Reactivity |
|---|---|---|---|
| HY-P81352 | 5T4 Antibody (YA1097) | IHC-P | Human |
| HY-P81352A | 5T4 Antibody (YA1097)(PBS only) | IHC-P | Human |
Related Diseases
| Diseases | Alias | |
|---|---|---|
| Congenital Disorder Of Glycosylation, Type Il |
|
|
| Renal Cell Carcinoma, Nonpapillary |
|
|
| Colorectal Cancer |
|
|
Related Agents
- Pre-clinical Phase
Pre-clinical Phase
| Cat. No. | Product Name |
Effect
|
Purity |
Rare Diseases
|
|---|---|---|---|---|
| HY-RS14925 | TPBG Human Pre-designed siRNA Set A | Pre-designed Set | / | Unkown |
| HY-RS18049 | Tpbg Mouse Pre-designed siRNA Set A | Pre-designed Set | / | Unkown |
| HY-RS24523 | Tpbg Rat Pre-designed siRNA Set A | Pre-designed Set | / | Unkown |
| Cat. No. | Product Name |
Effect
|
Purity |
Rare Diseases
|
|---|---|---|---|---|
| HY-P990532 | Anti-TPBG Antibody | Activator | 96.81% | Unkown |
| HY-P992184 | Anti-5T4 scFv-Fc Antibody | / | Unkown | |
| HY-P991410 | 5T4_0108 | Inhibitor | / | Unkown |
Orthologs Information
| Species | Symbol | Source | ID |
|---|---|---|---|
| Canis familiaris | TPBG | VGNC | VGNC:47731 |
| Felis catus | TPBG | VGNC | VGNC:66469 |
| Rattus norvegicus | TPBG | RGD | RGD:621453 |
| Bos taurus | TPBG | VGNC | VGNC:36242 |
| Mus musculus | TPBG | MGD | MGI:1341264 |
| Macaca mulatta | TPBG | VGNC | VGNC:78631 |
| Others | TPBG | NCBI |
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