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Cat. No.: HY-P2207A

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Sinapultide TFA

Sinapultide TFA is a 21-amino-acid peptide that mimics the action of human surfactant protein-B (SP-B). Sinapultide TFA can be used for synthetic phospholipids surfactants improvement.

For research use only. We do not sell to patients.

CAS No.: 2828433-25-4
Formula: C₁₂₈H₂₃₉F₃N₂₆O₂₄
Molecular Weight:2583.42

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Sinapultide TFA Chemical Structure

CAS No.: 2828433-25-4

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
- In Vivo
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

Sinapultide TFA is a 21-amino-acid peptide that mimics the action of human surfactant protein-B (SP-B). Sinapultide TFA can be used for synthetic phospholipids surfactants improvement^[1].

In Vitro

Sinapultide TFA microbubble preparation (2 μg/mL, 5 μg/mL; 24 h) combined with ultrasound (0.5 MHz, 40 s) could promote the function recovery of injured AT II cells effectively via affecting TNF-α and IL-6 levels^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Sinapultide TFA-loaded microbubbles (MBs) (0.1 mg; nasal delivery; collected at 3, 6, 12 and 24 hours after LPS) improves pulmonary edema in lung injury and increases lung W/D weight in LPS-induced ALI mice^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 2828433-25-4
Molecular Weight 2583.42
Formula C₁₂₈H₂₃₉F₃N₂₆O₂₄
Sequence Shortening

KLLLLKLLLLKLLLLKLLLLK (TFA)
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (258 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Braide-Moncoeur O, et al. Peptide-based synthetic pulmonary surfactant for the treatment of respiratory distress disorders. Curr Opin Chem Biol. 2016 Jun;32:22-8. [Content Brief]

[2]. Liu D, et al. Sinapultide TFA-Loaded Microbubbles Combined with Ultrasound to Attenuate Lipopolysaccharide-Induced Acute Lung Injury in Mice. Drug Des Devel Ther. 2020 Dec 22;14:5611-5622. [Content Brief]

Calculators

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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