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Cat. No.: HY-189941

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SP-835G

SP-835G is a potent Dengue Virus inhibitor with an EC₅₀ of 0.1 μM against DENV2. SP-835G, as a prodrug, is reduced by mitochondrial MARC enzymes to the active metabolite SP-835A, which binds to the allosteric site of NS2B-NS3 protease and blocks both cis and trans cleavage of the protease by restricting the dynamic changes of the helicase subdomain. SP-835G inhibits Dengue virus replication in infected cells with very low cytotoxicity. SP-835G can be used for research on dengue fever.

For research use only. We do not sell to patients.

Formula: C₂₇H₂₃BrN₈O₃
Molecular Weight:587.43

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

SP-835G Chemical Structure

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

Cellular Effect

Cell Line	Type	Value	Description	References
Huh-7	EC₅₀	0.1 μM	Antiviral activity against human HuH7 cells infected with EDEN2 (DENV2) at MOI 0.3 one-hour post infection, measured as EC50 average of two independent experiments. Antiviral activity against human HuH7 cells infected with EDEN2 (DENV2) at MOI 0.3 one-hour post infection, measured as EC50 average of two independent experiments.	slct.74553
Huh-7	CC₅₀	> 100 μM	Cytotoxicity against human HuH7 cells assessed up to 100 μM with CC₅₀ >100 μM. Cytotoxicity against human HuH7 cells assessed up to 100 μM with CC₅₀ >100 μM.	slct.74553

In Vitro

Viral Infection

SP-835G (48 h) significantly inhibits viral replication in DENV2 (EDEN2)-infected HuH-7 cells, with an EC₅₀ of 0.1 μM and very low cytotoxicity (CC₅₀ > 100 μM)^[1].
SP-835G (100 μM) achieves up to 97% viral clearance in BHK-21 cells infected with DENV2 (EDEN2)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Related Protocols :

Chemical Information

Molecular Weight 587.43
Formula C₂₇H₂₃BrN₈O₃
SMILES

N/C(C1=CC(C2=NC(N(CC3=CC=C(Br)C=C3)C=N4)=C4C(OCC5=CC=CC(/C(N)=N/O)=C5)=N2)=CC=C1)=N\O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Kiousis D, et al. Design and synthesis of a potent, cell active purine-based amidoxime against the dengue virus. ChemistrySelect. 2026.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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