2. Apoptosis Cell Cycle/DNA Damage Protein Tyrosine Kinase/RTK
  3. Apoptosis DNA Alkylator/Crosslinker VEGFR PDGFR
  4. Sunitinib-platinum(IV) prodrug-1

Sunitinib-platinum(IV) prodrug-1 (Complex A) is a Pt(IV) prodrug based on Cisplatin (HY-17394), and this design aims to enable Pt(IV) to be reduced to active Pt(II) under intracellular reducing conditions, while simultaneously releasing a derivative of Sunitinib (HY-10255A) with tyrosine kinase inhibitor (TKI) activity. Sunitinib-platinum(IV) prodrug-1 exhibits excellent cytotoxicity against renal cell carcinoma (RCC), causing DNA crosslinking and apoptosis. Sunitinib-platinum(IV) prodrug-1 inhibits the VEGFR/PDGFR signaling pathway, suppressing tumor growth and angiogenesis. Sunitinib-platinum(IV) prodrug-1 can be used for research on renal cell carcinoma.

For research use only. We do not sell to patients.

Sunitinib-platinum(IV) prodrug-1

Sunitinib-platinum(IV) prodrug-1 Chemical Structure

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Sunitinib-platinum(IV) prodrug-1 Related Antibodies

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Description

Sunitinib-platinum(IV) prodrug-1 (Complex A) is a Pt(IV) prodrug based on Cisplatin (HY-17394), and this design aims to enable Pt(IV) to be reduced to active Pt(II) under intracellular reducing conditions, while simultaneously releasing a derivative of Sunitinib (HY-10255A) with tyrosine kinase inhibitor (TKI) activity. Sunitinib-platinum(IV) prodrug-1 exhibits excellent cytotoxicity against renal cell carcinoma (RCC), causing DNA crosslinking and apoptosis. Sunitinib-platinum(IV) prodrug-1 inhibits the VEGFR/PDGFR signaling pathway, suppressing tumor growth and angiogenesis. Sunitinib-platinum(IV) prodrug-1 can be used for research on renal cell carcinoma[1].

Molecular Weight

699.42

Formula

C20H24Cl2FN5O5Pt
SMILES

CC1=C(C(C)=C(N1)/C=C2C(NC3=C\2C=C(C=C3)F)=O)C(NCCCC(O[Pt](N)(O)(Cl)(Cl)N)=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Sunitinib-platinum(IV) prodrug-1 Related Classifications

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This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Sunitinib-platinum(IV) prodrug-1ApoptosisDNA Alkylator/CrosslinkerVEGFRPDGFRVascular endothelial growth factor receptorPlatelet-derived growth factor receptorPt(IV) prodrugSunitinib conjugateRenal cell carcinomaTargeted therapyCombination therapyCisplatin-based complexKinase inhibitorDrug deliveryIn vivo efficacyReduced systemic toxicityInhibitorinhibitorinhibit

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