SRP14 - signal recognition particle 14 Gene

Also Known as ALURBP

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 6727

About SRP14

Cytogenetic location: 15q15.1 Genomic coordinates (GRCh38): 15:40,035,690-40,039,202 (from NCBI)

This gene has 8 transcripts (splice variants) and 242 orthologues. Ubiquitous expression in endometrium (RPKM 125.3), adrenal (RPKM 118.3) and 25 other tissues.

Summary

Enables RNA binding activity. Involved in protein targeting to ER. Located in nucleus. Part of signal recognition particle, endoplasmic reticulum targeting. [provided by Alliance of Genome Resources, Apr 2022]

SRP14 Products (2)

mRNA Protein Name
NM_001309434.1 NP_001296363.1 signal recognition particle 14 kDa protein isoform 2
NM_003134.6 NP_003125.3 signal recognition particle 14 kDa protein isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
11089964 GOA
Biological Process GO Annotation Evidence References Source
involved in protein targeting to ER IMP
IMP: Inferred from mutant phenotype
18089836 GOA
Cellular Component GO Annotation Evidence References Source
located in nucleus IDA
IDA: Inferred from direct assay
22720776 GOA
part of signal recognition particle, endoplasmic reticulum targeting IDA
IDA: Inferred from direct assay
18089836 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SRP14 Protein Structure

SRP14

SRP14: Signal recognition particle 14kD protein (4 - 94)

  • 0
  • 100
  • 136 a.a.
Protein Preferred Names Protein Names

signal recognition particle 14 kDa protein

  • 18 kDa Alu RNA-binding protein

SRP14 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
SRP14 P37108 SPANXN2 Homo sapiens Q5MJ10
Validated Y2H
32296183
Intra
SRP14 P37108 SRP9 Homo sapiens P49458-1
Ion Exchange Chrom
11089964
Intra
SRP14 P37108 SRP9 Homo sapiens P49458-1
X-Ray Diffraction
11089964
Intra
SRP14 P37108 SRP9 Homo sapiens P49458
Y2H Array
32296183
Intra
SRP14 P37108 SRP9 Homo sapiens P49458
Y2H Prey Pooling
32296183
Intra
SRP14 P37108 SRP9 Homo sapiens P49458
Anti Tag CoIP
35271311
Intra
SRP14 P37108 SRP9 Homo sapiens P49458
Validated Y2H
32296183
Intra
SRP14 P37108 DDX31 Homo sapiens Q9H8H2
Anti Tag CoIP
33961781
Intra
SRP14 P37108 EAF1 Homo sapiens Q96JC9
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS13771 SRP14 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus SRP14 VGNC VGNC:80833
Mus musculus SRP14 MGD MGI:107169
Rattus norvegicus SRP14 RGD RGD:1308506
Bos taurus SRP14 VGNC VGNC:35284
Others SRP14 NCBI