PEK
Four stress sensors converge on one output: phosphorylation of Ser51 on the alpha subunit of eIF2, which switches translation from global protein synthesis to selective expression of ATF4. HRI (EIF2AK1) is heme-regulated and protects erythroid cells from oxidative and iron stress; PKR (EIF2AK2) is activated by double-stranded RNA and mediates the antiviral interferon response; PERK (EIF2AK3), the family's namesake, senses unfolded protein in the endoplasmic reticulum and drives the unfolded protein response; and GCN2 (EIF2AK4) binds uncharged tRNA during amino acid starvation. PERK loss-of-function mutations cause Wolcott-Rallison syndrome, and each kinase is a pharmacological target in metabolic, infectious and oncological disease.
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PEK Recombinant Proteins (1)
- Species:
- Source:
Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- Formula: Human
- Molecular Weight: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
