U-78517 dihydrochloride
U-78517 dihydrochloride, a Trolox (HY-101445) analog, is a potent antioxidant. U-78517 dihydrochloride inhibits DCVC (HY-19717)-induced lipid peroxidation, scavenges DPPH, oxygen- and nitrogen-based free radicals. U-78517 dihydrochloride attenuates hypoxic injury in iaolated cardiac myocytes. U-78517 dihydrochloride can be used for the research of hypoxic injury, cerebral ischemia, and cardiovascular disease.
For research use only. We do not sell to patients.
- CAS No.: 133681-84-2
- Formula: C30H46Cl2N6O2
- Molecular Weight:593.63
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
U-78517 (compound U-78517F) (100 µM; 0-3 h) dihydrochloride completely inhibits DCVC-induced lipid peroxidation fails to attenuate cell damage in rabbit renal cortical slices[1].
U-78517F (0.3-3 μM; 90 min) dihydrochloride preserves sarcolemmal integrity, reduces hypoxi-induced creatinine kinase and LDH loss in neonatal rat cardiac myocytes, (EC50 = 1.7 μM), but does not prevent ATP depletion[2].
U-78517 (0-0.02 mM) dihydrochloride scavenges superoxide radicals in a concentration-dependent manner (IC50 = 6.0 μM)[3].
U-78517 (0.4-0.8 mM) dihydrochloride scavenges hydroxyl radicals in a concentration-dependent manner (IC50 = 600 μM)[3].
U-78517 dihydrochloride (100 μM; 1 min) directly scavenges DPPH radicals, eliminating the EPR signal and altering the solution color[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 133681-84-2
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Molecular Weight 593.63
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Formula C30H46Cl2N6O2
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SMILES
OC1=C(C)C2=C(OC(CN3CCN(CC3)C4=NC(N5CCCC5)=NC(N6CCCC6)=C4)(CC2)C)C(C)=C1C.Cl.Cl
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Davis JW, et al. Inhibition of S-(1,2-dichlorovinyl)-L-cysteine-induced lipid peroxidation by antioxidants in rabbit renal cortical slices: dissociation of lipid peroxidation and toxicity. J Biochem Toxicol. 1994;9(3):121-130. [Content Brief]
[2]. Linseman DA, et al. The trolox analog, U-78517F, attenuates hypoxic injury in isolated cardiac myocytes. J Mol Cell Cardiol. 1994;26(9):1249-1257. [Content Brief]
[3]. Zhao W, et al. An in vitro EPR study of the free-radical scavenging actions of the lazaroid antioxidants U-74500A and U-78517F. Free Radic Biol Med. 1995;19(1):21-30. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
U-78517 dihydrochloride Related Classifications
HY-164295A Related Classifications
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- U-78517
- 133681-84-2
- U78517
- U 78517
- Free Radical Scavengers
- Drug Derivative
- hypoxic injury
- neonatal myocytes
- DCVC-induced lipid peroxidation
- rabbit renal cortical slices
- cerebral ischemia
- DCVC-dependent cytotoxicity
- creatine kinase
- cardiac myocytes
- nitrogen-based free radicals
- hypoxia
- oxygen-based free radicals
- lactate dehydrogenase
- hydroxyl radicals
- lazaroid
- cardiovascular disease
- free radical interactions
- superoxide radicals
- sarcolemmal integrity
- DPPH radicals
- Inhibitor
- inhibitor
- inhibit