U-78517 dihydrochloride 

U-78517 dihydrochloride, a Trolox (HY-101445) analog, is a potent antioxidant. U-78517 dihydrochloride inhibits DCVC (HY-19717)-induced lipid peroxidation, scavenges DPPH, oxygen- and nitrogen-based free radicals. U-78517 dihydrochloride attenuates hypoxic injury in iaolated cardiac myocytes. U-78517 dihydrochloride can be used for the research of hypoxic injury, cerebral ischemia, and cardiovascular disease^[1][2][3].

U-78517 (compound U-78517F) (100 µM; 0-3 h) dihydrochloride completely inhibits DCVC-induced lipid peroxidation fails to attenuate cell damage in rabbit renal cortical slices^[1].
U-78517F (0.3-3 μM; 90 min) dihydrochloride preserves sarcolemmal integrity, reduces hypoxi-induced creatinine kinase and LDH loss in neonatal rat cardiac myocytes, (EC₅₀ = 1.7 μM), but does not prevent ATP depletion^[2].
U-78517 (0-0.02 mM) dihydrochloride scavenges superoxide radicals in a concentration-dependent manner (IC₅₀ = 6.0 μM)^[3].
U-78517 (0.4-0.8 mM) dihydrochloride scavenges hydroxyl radicals in a concentration-dependent manner (IC₅₀ = 600 μM)^[3].
U-78517 dihydrochloride (100 μM; 1 min) directly scavenges DPPH radicals, eliminating the EPR signal and altering the solution color^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

593.63

C₃₀H₄₆Cl₂N₆O₂

133681-84-2

OC1=C(C)C2=C(OC(CN3CCN(CC3)C4=NC(N5CCCC5)=NC(N6CCCC6)=C4)(CC2)C)C(C)=C1C.Cl.Cl

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Davis JW, et al. Inhibition of S-(1,2-dichlorovinyl)-L-cysteine-induced lipid peroxidation by antioxidants in rabbit renal cortical slices: dissociation of lipid peroxidation and toxicity. J Biochem Toxicol. 1994;9(3):121-130.  [Content Brief]

  [2]. Linseman DA, et al. The trolox analog, U-78517F, attenuates hypoxic injury in isolated cardiac myocytes. J Mol Cell Cardiol. 1994;26(9):1249-1257.  [Content Brief]

  [3]. Zhao W, et al. An in vitro EPR study of the free-radical scavenging actions of the lazaroid antioxidants U-74500A and U-78517F. Free Radic Biol Med. 1995;19(1):21-30.  [Content Brief]