133681-84-2
Chemical Structure
U-78517 dihydrochloride
- CAS No.: 133681-84-2
- Formula:C30H46Cl2N6O2
- Molecular Weight:593.63
IUPAC Name: 2-((4-(2,6-di(pyrrolidin-1-yl)pyrimidin-4-yl)piperazin-1-yl)methyl)-2,5,7,8-tetramethylchroman-6-ol hydrochloride
InChIKey: KJGXSMZHYBXPIS-UHFFFAOYSA-N
SMILES: OC1=C(C)C2=C(OC(CN3CCN(CC3)C4=NC(N5CCCC5)=NC(N6CCCC6)=C4)(CC2)C)C(C)=C1C.Cl.Cl
Biological Activity: U-78517 dihydrochloride, a Trolox (HY-101445) analog, is a potent antioxidant. U-78517 dihydrochloride inhibits DCVC (HY-19717)-induced lipid peroxidation, scavenges DPPH, oxygen- and nitrogen-based free radicals. U-78517 dihydrochloride attenuates hypoxic injury in iaolated cardiac myocytes. U-78517 dihydrochloride can be used for the research of hypoxic injury, cerebral ischemia, and cardiovascular disease[1][2][3].
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U-78517 dihydrochloride | U-78517 dihydrochloride, a Trolox (HY-101445) analog, is a potent antioxidant. U-78517 dihydrochloride inhibits DCVC (HY-19717)-induced lipid peroxidation, scavenges DPPH, oxygen- and nitrogen-based free radicals. U-78517 dihydrochloride attenuates hypoxic injury in iaolated cardiac myocytes. U-78517 dihydrochloride can be used for the research of hypoxic injury, cerebral ischemia, and cardiovascular disease. | |||||||||||||||||||||
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References
- [1]. Davis JW, et al. Inhibition of S-(1,2-dichlorovinyl)-L-cysteine-induced lipid peroxidation by antioxidants in rabbit renal cortical slices: dissociation of lipid peroxidation and toxicity. J Biochem Toxicol. 1994;9(3):121-130. [Content Brief]
- [2]. Linseman DA, et al. The trolox analog, U-78517F, attenuates hypoxic injury in isolated cardiac myocytes. J Mol Cell Cardiol. 1994;26(9):1249-1257. [Content Brief]
- [3]. Zhao W, et al. An in vitro EPR study of the free-radical scavenging actions of the lazaroid antioxidants U-74500A and U-78517F. Free Radic Biol Med. 1995;19(1):21-30. [Content Brief]
