CLDN3 - claudin 3 Gene

Also Known as RVP1; HRVP1; C7orf1; CPE-R2; CPETR2

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 1365

About CLDN3

Cytogenetic location: 7q11.23 Genomic coordinates (GRCh38): 7:73,768,997-73,770,270 (from NCBI)

This gene has 1 transcript (splice variant), 151 orthologues and 22 paralogues.

Summary

Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. These junctions are comprised of sets of continuous networking strands in the outwardly facing cytoplasmic leaflet, with complementary grooves in the inwardly facing extracytoplasmic leaflet. The protein encoded by this intronless gene, a member of the Claudin family, is an integral membrane protein and a component of tight junction strands. It is also a low-affinity receptor for Clostridium perfringens enterotoxin, and shares aa sequence similarity with a putative apoptosis-related protein found in rat. [provided by RefSeq, Jul 2008]

CLDN3 Products (1)

mRNA	Protein	Name
NM_001306.4	NP_001297.1	claudin-3

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables identical protein binding	IDA IDA: Inferred from direct assay	28028216	GOA
enables identical protein binding	IPI IPI: Inferred from physical interaction	25849148	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	25849148	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in actin cytoskeleton organization	IMP IMP: Inferred from mutant phenotype	27593915	GOA
involved in bicellular tight junction assembly	IMP IMP: Inferred from mutant phenotype	25849148	GOA
involved in negative regulation of cell migration	IMP IMP: Inferred from mutant phenotype	27593915	GOA
involved in negative regulation of cell population proliferation	IMP IMP: Inferred from mutant phenotype	27593915	GOA
involved in negative regulation of gene expression	IMP IMP: Inferred from mutant phenotype	27593915	GOA
involved in negative regulation of wound healing	IMP IMP: Inferred from mutant phenotype	27593915	GOA
involved in positive regulation of bicellular tight junction assembly	IMP IMP: Inferred from mutant phenotype	20655293	GOA
involved in positive regulation of cell junction assembly	IMP IMP: Inferred from mutant phenotype	27593915	GOA
involved in positive regulation of cell migration	IMP IMP: Inferred from mutant phenotype	16103090	GOA
involved in positive regulation of gene expression	IMP IMP: Inferred from mutant phenotype	27593915	GOA
involved in positive regulation of metallopeptidase activity	IMP IMP: Inferred from mutant phenotype	16103090	GOA
involved in positive regulation of protein phosphorylation	IMP IMP: Inferred from mutant phenotype	27593915	GOA
involved in positive regulation of wound healing	IMP IMP: Inferred from mutant phenotype	16103090	GOA
involved in regulation of cell morphogenesis	IMP IMP: Inferred from mutant phenotype	16103090	GOA
involved in regulation of membrane permeability	IMP IMP: Inferred from mutant phenotype	20655293	GOA
involved in regulation of transepithelial transport	IMP IMP: Inferred from mutant phenotype	27593915	GOA
involved in response to hypoxia	IEP IEP: Inferred from expression pattern	15174142	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in apical junction complex	IMP IMP: Inferred from mutant phenotype	27593915	GOA
located in bicellular tight junction	IDA IDA: Inferred from direct assay	25849148	GOA
located in cell-cell junction	IDA IDA: Inferred from direct assay	18774778	GOA
part of protein-containing complex	IDA IDA: Inferred from direct assay	25849148	GOA
located in tight junction	IDA IDA: Inferred from direct assay	30734065	GOA
located in tight junction	IMP IMP: Inferred from mutant phenotype	20655293	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CLDN3 Protein Structure

PMP22_Claudin

0
100
200
220 a.a.

Protein Preferred Names	Protein Names
claudin-3	CPE-R 2

Recombinant CLDN3 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P72146	Claudin-3/CLDN3 Protein, Human (His-B2M)	O15551 (R30-R80)	≥ 90%, as determined by reducing SDS-PAGE.
HY-P700472	Claudin-3/CLDN3 Protein-VLP, Human (HEK293, His)	O15551 (M1-V220)	Purity analysis by SDS-PAGE is not available for VLP proteins.

CLDN3 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P82767	Claudin 3 Antibody (YA2512)	WB, ICC/IF, IP	Human
HY-P82767A	Claudin 3 Antibody (YA2512)(PBS only)	WB, ICC/IF, IP	Human
HY-P86091	Claudin 3 Antibody (YA5783)	WB, IHC-P, IP, ELISA, IF-Tissue	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Papillary Carcinoma	Carcinoma, Papillary Carcinoma Papillary
Williams-Beuren Syndrome	Williams Syndrome WBS Wms Deletion 7q11.23 Monosomy 7q11.23 Chromosome 7q11.23 Deletion Syndrome, 1.5- To 1.8-Mb Fanconi Schlesinger Syndrome Beuren Syndrome Elfin Facies Syndrome Elfin Facies With Hypercalcemia Hypercalcemia-Supravalvar Aortic Stenosis Ws
Endometrial Cancer	Endometrial Carcinoma Endometrial Neoplasm Malignant Neoplasm Of Endometrium Endometrioid Carcinoma Endometrial Neoplasms Carcinoma, Endometrioid Endometrial Cancer, Familial Endometrial Carcinoma, Somatic Endometrial Cancer, Susceptibility To Endometrial Ca Malignant Endometrial Neoplasm Neoplasm Of Endometrium Primary Malignant Neoplasm Of Endometrium Tumor Of Endometrium Carcinoma Of The Endometrium Endometrioid Carcinoma Of Female Reproductive System ENDMC Carcinoma Endometrioid Endometrial Cancers Cancer, Endometrial Uterine Corpus Cancer
Ovarian Cancer	Ovarian Carcinoma Ovarian Neoplasm Malignant Tumour Of Ovary Cancer Of The Ovary Epithelial Ovarian Cancer Neoplasm Of Ovary Ovarian Neoplasms Ovarian Cancers Malignant Neoplasm Of Ovary Primary Malignant Neoplasm Of Ovary Ovarian Cancer, Somatic Malignant Ovarian Tumor Ovary Neoplasm Primary Ovarian Cancer Tumor Of The Ovary Malignant Neoplasm Of The Ovary Malignant Tumor Of The Ovary Ovarian Malignant Tumor OC Ovarian Carcinomas Cancer, Ovarian Cancer Of Ovary Ovary Cancer Ca Ovary
Colorectal Cancer	Colon Cancer Colorectal Carcinoma Colon Carcinoma Colorectal Cancer, Susceptibility To Carcinoma Of Colon CRC Colorectal Cancer With Chromosomal Instability, Somatic Colon Cancer, Somatic Colon Cancer, Susceptibility To Colonic Neoplasms Colorectal Neoplasms Colorectal Cancer, Somatic Colon Cancer, Advanced, Somatic Colonic Carcinoma Colorectal Carcinomas Colon Cancers Colorectal Cancers Cancer, Colorectal, Somatic Cancer, Colon Cancer, Colorectal, Susceptibility To Colorectal Neoplasm Colonic Neoplasm Malignant Tumor Of Colon
Gastric Cancer	Stomach Cancer Gastric Carcinoma Stomach Carcinoma Gastric Cancer, Somatic Gastric Neoplasm Carcinoma Of Stomach Stomach Neoplasms Malignant Neoplasm Of Stomach Gastric Cancer Risk After H. Pylori Infection Cancer Of The Stomach Adult Stomach Cancer Adult Stomach Carcinoma GASC Gastric Cancer Intestinal Gastric Cancers Gastric Carcinomas Cancer, Gastric Stomach Neoplasm Malignant Neoplasm Of Body Of Stomach Malignant Tumor Of Lesser Curve Of Stomach Gastrocarcinoma Of Unspecified Site Leather Bottle Stomach Carcinoma Of Fundus Of Stomach Cancer Of Fundus Of Stomach Primary Malignant Neoplasm Of Body Of Stomach Cancer Of Body Of Stomach Primary Malignant Neoplasm Of Pyloric Antrum Pyloric Antrum Cancer Malignant Tumour Of Stomach
Deafness, Autosomal Recessive 29	DFNB29 Autosomal Recessive Nonsyndromic Deafness 29 Autosomal Recessive Deafness 29 Deafness, Autosomal Recessive, 29 Non-Syndromic Neurosensory Deafness Autosomal Recessive Type 29 Non-Syndromic Sensorineural Deafness Autosomal Recessive Type 29 Deafness, Autosomal Recessive, Type 29
Perinatal Necrotizing Enterocolitis	Necrotizing Enterocolitis Enterocolitis Necrotizing Enterocolitis, Necrotizing Necrotizing Enterocolitis In Fetus Or Newborn Perinatal Necrotising Enterocolitis Pseudomembranous Enterocolitis In Newborn Nec
Ovarian Cystadenoma	Cystoma Serosum Simplex Simple Cystoma Of Ovary Simple Cystoma Of The Ovary
Celiac Disease 1	Celiac Disease Coeliac Disease Celiac Sprue Celiac Disease, Susceptibility To Gluten-Sensitive Enteropathy Nontropical Sprue Sprue CELIAC1 Celiac Disease, Susceptibility To, 1 Celiac Sprue 1 Celiac Sprue, Susceptibility To, 1 Gluten-Sensitive Enteropathy 1 Gluten-Sensitive Enteropathy, Susceptibility To, 1 Idiopathic Steatorrhea Cœliac Disease Gluten Intolerance Gluten-Induced Enteropathy Gluten Enteropathy Celiac Disease, Susceptibility To, Type 1 Childhood Celiac Disease Coeliac Rickets Gee Disease Gee-Herter Disease Heubner-Herter Disease Idiopathic Steatorrhoea Thaysen'S Disease Herter Gee Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS02771	CLDN3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS20885	Cldn3 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS27402	Cldn3 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P991946	Anti-CLDN3 Antibody		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	CLDN3	MGD	MGI:1329044
Canis familiaris	CLDN3	VGNC	VGNC:39319
Bos taurus	CLDN3	VGNC	VGNC:27414
Rattus norvegicus	CLDN3	RGD	RGD:68425
Felis catus	CLDN3	VGNC	VGNC:107750
Macaca mulatta	CLDN3	VGNC	VGNC:71250
Others	CLDN3	NCBI