GALK2 - galactokinase 2 Gene

Also Known as GK2

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 2585

About GALK2

Cytogenetic location: 15q21.1-q21.2 Genomic coordinates (GRCh38): 15:49,155,774-49,367,740 (from NCBI)

This gene has 22 transcripts (splice variants), 202 orthologues and 2 paralogues. Ubiquitous expression in kidney (RPKM 4.3), duodenum (RPKM 3.4) and 25 other tissues.

Summary

This gene encodes a highly efficient N-acetylgalactosamine (GalNAc) kinase, which has Galactokinase activity when galactose is present at high concentrations. The encoded protein is a member of the GHMP kinase family. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2017]

GALK2 Products (6)

mRNA Protein Name
NM_001001556.3 NP_001001556.1 N-acetylgalactosamine kinase isoform 2
NM_001289030.2 NP_001275959.1 N-acetylgalactosamine kinase isoform 3
NM_001289031.1 NP_001275960.1 N-acetylgalactosamine kinase isoform 3
NM_001352047.1 NP_001338976.1 N-acetylgalactosamine kinase isoform 4
NM_001352048.2 NP_001338977.1 N-acetylgalactosamine kinase isoform 4
NM_002044.4 NP_002035.1 N-acetylgalactosamine kinase isoform 1

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables galactokinase activity IDA
IDA: Inferred from direct assay
7542884 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GALK2 Protein Structure

GalKase_gal_bdg

GalKase_gal_bdg: Galactokinase galactose-binding signature (24 - 73)

GHMP_kinases_N

GHMP_kinases_N: GHMP kinases N terminal domain (133 - 196)

GHMP_kinases_C

GHMP_kinases_C: GHMP kinases C terminal (355 - 418)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 458 a.a.
Protein Preferred Names Protein Names

N-acetylgalactosamine kinase

  • galNAc kinase

Recombinant GALK2 Proteins

Cat. No. Product Name Accession Purity
HY-P70404 N-acetylgalactosamine kinase/GALK2 Protein, Human (HEK293, His) Q01415-1 (M1-A458) ≥ 95%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases Alias
Galactosemia I

  • Galactosemia

  • Galt Deficiency

  • Classic Galactosemia

  • Galactose-1-Phosphate Uridylyltransferase Deficiency

  • Galactose-1-Phosphate Uridyltransferase Deficiency

  • GALAC1

  • Galactosemia, Classic

  • Galactosemia Type 1

  • Galactosemias

  • Classical Galactosemia

  • Galactosaemia

  • Galactose Intolerance

  • Epimerase Deficiency Galactosemia

  • Galactokinase Deficiency Disease

  • Galactose Epimerase Deficiency

  • Galactose-1-Phosphate Uridyl-Transferase Deficiency Disease

  • Gale Deficiency

  • Galk Deficiency

  • Udp-Galactose-4-Epimerase Deficiency Disease

  • Utp Hexose-1-Phosphate Uridylyltransferase Deficiency

  • Galactosemia 1

  • Galactosemia, Duarte Variant

  • Deficiency Of Galactokinase

  • Udpglucose 4-Epimerase Deficiency Disease

  • Classical Galactosaemia

  • Galput Deficiency - [Galactose-4-Phosphate Uridyltransferase] Deficiency

  • Classic Galactosaemia

  • Deficiency Of Hexose-1-Phosphate Uridylyltransferase

  • Deficiency Of Udpglucose-Hexose-1-Phosphate Uridylyltransferase

  • Deficiency Of Galactose-1-Phosphate Uridylyltransferase

  • Galactose-1-Phosphate Uridyl Transferase Deficiency

  • Transferase Deficiency Galactosemia

  • Deficiency Of Uridyl Transferase

  • Deficiency Of Utp-Hexose-1-Phosphate Uridylyltransferase

  • Utp-Hexose-1-Phosphate Uridyltransferase Deficiency
Galactosemia Iii

  • Galactose Epimerase Deficiency

  • Gale Deficiency

  • Udp-Galactose-4-Epimerase Deficiency

  • Epimerase Deficiency Galactosemia

  • Galactosemia Type 3

  • Gale-D

  • Uridine Diphosphate Galactose-4-Epimerase Deficiency

  • GALAC3

  • Galactosemia 3

  • Generalized Uridine Diphosphate Galactose-4-Epimerase Deficiency

  • Erythrocyte Uridine Diphosphate Galactose-4-Epimerase Deficiency

  • Galactosemia Type Iii

  • Udp-Galactose-4'-Epimerase Deficiency

  • Generalized Galactose Epimerase Deficiency

  • Generalized Gale Deficiency

  • Generalized Gale-D

  • Generalized Udp-Galactose-4-Epimerase Deficiency

  • Generalized Epimerase Deficiency Galactosemia

  • Erythrocyte Galactose Epimerase Deficiency

  • Erythrocyte Gale Deficiency

  • Erythrocyte Gale-D

  • Erythrocyte Udp-Galactose-4-Epimerase Deficiency

  • Erythrocyte Epimerase Deficiency Galactosemia

  • Galactosemias

  • Classical Galactosemia

  • Udpglucose 4-Epimerase Deficiency Disease
Galactosemia Ii

  • Galactokinase Deficiency

  • Galk Deficiency

  • Galactokinase Deficiency With Cataracts

  • Deficiency Of Galactokinase

  • GALAC2

  • Galk-D

  • Galactokinase Deficiency Galactosemia

  • Galactosemia 2

  • Galactosemia Type 2

  • Hereditary Galactokinase Deficiency

  • Galactokinase Deficiency, Cataract

  • Galactosemias

  • Galk - [Galactokinase Deficiency]
Superficial Keratitis
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-173642 NCGC00238624 Inhibitor / Unkown
HY-RS05244 GALK2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20025 Galk2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26528 Galk2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris GALK2 VGNC VGNC:41082
Macaca mulatta GALK2 VGNC VGNC:72870
Felis catus GALK2 VGNC VGNC:62440
Mus musculus GALK2 MGD MGI:1917226
Bos taurus GALK2 VGNC VGNC:29220
Rattus norvegicus GALK2 RGD RGD:1308691
Others GALK2 NCBI