2. Protein Tyrosine Kinase/RTK
  3. VEGFR
  4. VEGFR-2-IN-20

VEGFR-2-IN-20 (Compound 7) is a potent inhibitor of VEGFR. VEGFR-2-IN-20 has the potential for the research of cancer diseases.

For research use only. We do not sell to patients.

VEGFR-2-IN-20

VEGFR-2-IN-20 Chemical Structure

CAS No. : 2404581-25-3

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VEGFR-2-IN-20 Related Antibodies

Top Publications Citing Use of Products

View All VEGFR Isoform Specific Products:

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VEGFR1/Flt-1 VEGFR2/KDR/Flk-1 VEGFR3/Flt-4

  • Biological Activity

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Description

VEGFR-2-IN-20 (Compound 7) is a potent inhibitor of VEGFR. VEGFR-2-IN-20 has the potential for the research of cancer diseases[1].

Cellular Effect
Cell Line Type Value Description References
HCT-116 IC50
4.58 μM
Compound: 39
Antiproliferative activity against human HCT-116 cells assessed as reduction in cell growth incubated for 24 hrs by MTT assay
Antiproliferative activity against human HCT-116 cells assessed as reduction in cell growth incubated for 24 hrs by MTT assay
[PMID: 38728867]
HCT-116 IC50
4.83 μM
Compound: 83
Antiproliferative activity against human HCT-116 cells assessed as reduction in cell growth incubated for 24 hrs by MTT assay
Antiproliferative activity against human HCT-116 cells assessed as reduction in cell growth incubated for 24 hrs by MTT assay
[PMID: 37453330]
HepG2 IC50
3.97 μM
Compound: 39
Antiproliferative activity against human HepG2 cells assessed as reduction in cell growth incubated for 24 hrs by MTT assay
Antiproliferative activity against human HepG2 cells assessed as reduction in cell growth incubated for 24 hrs by MTT assay
[PMID: 38728867]
HepG2 IC50
3.97 μM
Compound: 83
Antiproliferative activity against human HepG2 cells assessed as reduction in cell growth incubated for 24 hrs by MTT assay
Antiproliferative activity against human HepG2 cells assessed as reduction in cell growth incubated for 24 hrs by MTT assay
[PMID: 37453330]
MCF7 IC50
4.58 μM
Compound: 83
Antiproliferative activity against human MCF7 cells assessed as reduction in cell growth incubated for 24 hrs by MTT assay
Antiproliferative activity against human MCF7 cells assessed as reduction in cell growth incubated for 24 hrs by MTT assay
[PMID: 37453330]
MCF7 IC50
4.83 μM
Compound: 39
Antiproliferative activity against human MCF7 cells assessed as reduction in cell growth incubated for 24 hrs by MTT assay
Antiproliferative activity against human MCF7 cells assessed as reduction in cell growth incubated for 24 hrs by MTT assay
[PMID: 38728867]
Molecular Weight

396.46

Formula

C20H20N4O3S
CAS No.
SMILES

CCN1C(C2=CC=CC=C2N=C1SCC(NC3=CC=C(C=C3)/C(C)=N/O)=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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VEGFR-2-IN-20 Related Classifications

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This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

VEGFR-2-IN-202404581-25-3VEGFRVascular endothelial growth factor receptorcancerInhibitorinhibitorinhibit

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