2. Protein Tyrosine Kinase/RTK
  3. VEGFR
  4. VEGFR-2-IN-24

VEGFR-2-IN-24 is a potent VEGFR-2 inhibitor with IC50 value of 0.22 µM. VEGFR-2-IN-24 can be used for tumor research.

For research use only. We do not sell to patients.

VEGFR-2-IN-24

VEGFR-2-IN-24 Chemical Structure

CAS No. : 2455414-26-1

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VEGFR-2-IN-24 Related Antibodies

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VEGFR1/Flt-1 VEGFR2/KDR/Flk-1 VEGFR3/Flt-4

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Description

VEGFR-2-IN-24 is a potent VEGFR-2 inhibitor with IC50 value of 0.22 µM. VEGFR-2-IN-24 can be used for tumor research[1].

IC50 & Target[1]

VEGFR2

0.22 μM (IC50)

Cellular Effect
Cell Line Type Value Description References
HCT-116 IC50
8.99 μM
Compound: 44; 50
Cytotoxicity against human HCT-116 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
Cytotoxicity against human HCT-116 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
[PMID: 38728867]
HepG2 IC50
11.19 μM
Compound: 44; 50
Cytotoxicity against human HepG2 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
Cytotoxicity against human HepG2 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
[PMID: 38728867]
MCF7 IC50
7.1 μM
Compound: 44; 50
Cytotoxicity against human MCF7 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
Cytotoxicity against human MCF7 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
[PMID: 38728867]
In Vitro

VEGFR-2-IN-24 (Compound 8f) (0-1000 μM, 72 hours; human tumor cell lines) exerts the most potent antitumor activities against human cancer cell lines[1].
VEGFR-2-IN-24 (Compound 8f) (0-1000 μM, 72 hours; human tumor cell lines) displays the highest anticancer activities with IC50 values of 11.19, 8.99 and 7.10 μM for HepG2, HCT-116 and MCF-7 cell lines, respectively[1].
VEGFR-2-IN-24 (Compound 8f) (0-300 μg/mL, 5 min) remarkably exhibits VEGFR-2 inhibition with IC50 value of 0.22 µM[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

VEGFR-2-IN-24 Related Antibodies

Cell Cytotoxicity Assay[1]

Cell Line: Hepatocellular carcinoma (HepG2), breast cancer (MCF-7) and colorectal carcinoma (HCT-116).
Concentration: 0.1, 10, 100 and 1000 µM
Incubation Time: 72 hours
Result: Inhibited with IC50 values of 11.19, 8.99 and 7.10 μM for HePG-2, MCF-7 and HCT-116, respectively.
Molecular Weight

529.56

Formula

C28H23N3O6S
CAS No.
SMILES

O=C(OCC)C1=CC=C(NC(C2=CC=C(NC(CN(C/3=O)C(SC3=C/C4=CC=CC=C4)=O)=O)C=C2)=O)C=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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VEGFR-2-IN-24 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

VEGFR-2-IN-242455414-26-1VEGFRVascular endothelial growth factor receptorVEGFR-2anticancer agentthiazolidine-2,4-dioneInhibitorinhibitorinhibit

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