2. Antibody-drug Conjugate/ADC Related Cytoskeleton Cell Cycle/DNA Damage
  3. Antibody-Drug Conjugates (ADCs) Microtubule/Tubulin
  4. Vorsetuzumab mafodotin

Vorsetuzumab mafodotin  (Synonyms: Anti-Human CD70 Recombinant Antibody; SGN-75)

製品番号: HY-P99334 純度: 99.69%
COA 取扱説明書 Technical Support

Vorsetuzumab mafodotin (SGN-75) is an Auristatin-based anti-CD70 antibody-drug conjugate (ADC). Vorsetuzumab mafodotin consists of a humanized monoclonal antibody, Vorsetuzumab and an ADC cytotoxin MMAF. Vorsetuzumab mafodotin has antineoplastic activity.

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Vorsetuzumab mafodotin

Vorsetuzumab mafodotin 構造式

CAS 番号 : 1165741-01-4

容量 価格（税別） 在庫状況 数量
1 mg $950 在庫あり
5 mg $2950 在庫あり
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Vorsetuzumab mafodotin 関連抗体

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製品説明

Vorsetuzumab mafodotin (SGN-75) is an Auristatin-based anti-CD70 antibody-drug conjugate (ADC). Vorsetuzumab mafodotin consists of a humanized monoclonal antibody, Vorsetuzumab and an ADC cytotoxin MMAF. Vorsetuzumab mafodotin has antineoplastic activity[1].

体外実験

Vorsetuzumab mafodotin (SGN-75; 0.01-10000 ng/mL; for 96 h) induces dose-dependent cytotoxicity that is specific with an IC50 of 29 ng/mL[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Vorsetuzumab mafodotin 関連抗体

Cell Cytotoxicity Assay[1]

Cell Line: SK-OV-3 cells
Concentration: 0.01 ng/mL, 0.1 ng/mL, 1 ng/mL, 10 ng/mL, 100 ng/mL, 1000 ng/mL, 10000 ng/mL
Incubation Time: 96 h
Result: Induced dose-dependent cytotoxicity.
体内実験

Vorsetuzumab mafodotin (SGN-75; 3 mg/kg; four intraperitoneal injections at 4-day interval) significantly reduces median tumour volumes and delays tumour growth[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Nude (nu/nu) female mice injected with MiaPaCa-2/CD70 tumour pieces[1]
Dosage: 3 mg/kg
Administration: Intraperitoneal injection; every 4 days; for a total of four doses
Result: Significantly reduced median tumour volumes and delayed tumour growth.
臨床実験
分子量

150 kDa

CAS 番号
Appearance

Liquid

Color

Colorless to light yellow

SMILES

[Vorsetuzumab mafodotin]
輸送条件

Shipping with dry ice.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
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Vorsetuzumab mafodotin Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Vorsetuzumab mafodotin1165741-01-4Anti-Human CD70 Recombinant Antibody SGN-75SGN75SGN 75SGN-75Antibody-Drug Conjugates (ADCs)Microtubule/TubulinAntibody-Drug ConjugatesCD70ADCVorsetuzumabMMAFantineoplastic activityInhibitorinhibitorinhibit

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製品名:
Vorsetuzumab mafodotin
製品番号:
HY-P99334
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