α-Glucosidase-IN-18 

α-Glucosidase-IN-18 (7B) is an orally active α-glucosidase inhibitor with an IC₅₀ value of 3.96 μM. α-Glucosidase-IN-18 has antidiabetic activity^[1].

α-Glucosidase-IN-18 (7B) (p.o., 10 or 20 mg/kg) has antidiabetic activity and significantly reduces blood glucose levels, from 392.16 mg/dL of diabetic control to 112.97 mg/dL at a concentration of 20 mg/kg after 28 days, while effectively slowing weight loss due to diabetes in male Wistar albino rats with streptozotocin-induced diabetes^[1].
α-Glucosidase-IN-18 (7B) (p.o., 10 or 20 mg/kg) had an anti-hyperlipidemic effect with total CH levels from 226.03 mg/dL in the diabetic control to 136.4 mg/dL, LDL levels from 183.3 mg/dL to 114.18 mg/dL and TG levels from 189.35 mg/dL to 118.61 mg/dL in male Wistar albino rats with streptozotocin-induced diabetes^[1].
α-Glucosidase-IN-18 (7B) decreases ALP levels from 3.01 mg/dL to 0.85 mg/dL and 0.79 mg/dL, SGPT levels from 59.43 mg/dL to 27.07 mg/dL and 23.91 mg/dL, SGOT levels from 49.67 mg/dL to 26.71 mg/dL and 23.08 mg/dL, serum creatinine from 3.01 mg/dL to 0.85 mg/dL and 0.79 mg/dL, and insulin levels from 0.369 mg/dL to 0.621 mg/dL and 0.639 mg/dL, respectively at doses of 10 and 20 mg/kg in male Wistar albino rats with streptozotocin-induced diabetes^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

373.47

C₂₃H₁₉NO₂S

2820424-81-3

CC1=CC=C(C=C1)C2=NC3=C(SC(C2)C4=CC=C(C=C4)C(O)=O)C=CC=C3

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Rabia Mehmood, et al. Synthesis of Novel 2,3-Dihydro-1,5-Benzothiazepines as α-Glucosidase Inhibitors: In Vitro, In Vivo, Kinetic, SAR, Molecular Docking, and QSAR Studies. ACS Omega 2022, August 17, 2022.