β-Glucuronide-NB-bis[N(Me)-methyl ester]-MMAE
β-Glucuronide-NB-bis[N(Me)-methyl ester]-MMAE (compound 20) is auristatins-glucuronide conjugate. Antitumor agent-122 shows in vitro antiproliferative activities against β-glucuronidase pretreated and untreated cancer cells with an IC50 value of 5.7 nM - 9.7 nM. Antitumor agent-122 shows potent antitumor efficacy in HCT-116 xenograft mouse model without inducing side effects.
For research use only. We do not sell to patients.
- Formula: C59H92N8O19
- Molecular Weight:1217.40
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
![β-Glucuronide-NB-bis[N(Me)-methyl ester]-MMAE Chemical Structure](https://file.medchemexpress.com/product_pic/hy-155313.gif "Click to View β-Glucuronide-NB-bis[N(Me)-methyl ester]-MMAE Chemical Structure")
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| A549 | IC50 |
1.52 μM
Compound: 20
|
Antiproliferative activity against human A549 cells assessed as inhibition of cell growth
Antiproliferative activity against human A549 cells assessed as inhibition of cell growth
|
[PMID: 37793497] |
| A549 | IC50 |
6.38 nM
Compound: 20
|
Antiproliferative activity against human A549 cells assessed as inhibition of cell growth in presence of beta-glucuronidase
Antiproliferative activity against human A549 cells assessed as inhibition of cell growth in presence of beta-glucuronidase
|
[PMID: 37793497] |
| HCT-116 | IC50 |
1.49 μM
Compound: 20
|
Antiproliferative activity against human HCT-116 cells assessed as inhibition of cell growth
Antiproliferative activity against human HCT-116 cells assessed as inhibition of cell growth
|
[PMID: 37793497] |
| HCT-116 | IC50 |
6.61 nM
Compound: 20
|
Antiproliferative activity against human HCT-116 cells assessed as inhibition of cell growth in presence of beta-glucuronidase
Antiproliferative activity against human HCT-116 cells assessed as inhibition of cell growth in presence of beta-glucuronidase
|
[PMID: 37793497] |
| HeLa | IC50 |
1.65 μM
Compound: 20
|
Antiproliferative activity against human HeLa cells assessed as inhibition of cell growth
Antiproliferative activity against human HeLa cells assessed as inhibition of cell growth
|
[PMID: 37793497] |
| HeLa | IC50 |
5.73 nM
Compound: 20
|
Antiproliferative activity against human HeLa cells assessed as inhibition of cell growth in presence of beta-glucuronidase
Antiproliferative activity against human HeLa cells assessed as inhibition of cell growth in presence of beta-glucuronidase
|
[PMID: 37793497] |
Chemical Information
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Molecular Weight 1217.40
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Formula C59H92N8O19
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SMILES
CN(C)[C@@H](C(C)C)C(N[C@@H](C(C)C)C(N(C)[C@@H]([C@@H](C)CC)[C@H](OC)CC(N1[C@H]([C@H](OC)[C@@H](C)C(N[C@H](C)[C@@H](OC(N(CCN(C)C(OCC2=CC([N+]([O-])=O)=C(O[C@H]3[C@H](O)[C@@H](O)[C@H](O)[C@@H](C(O)=O)O3)C=C2)=O)C)=O)C4=CC=CC=C4)=O)CCC1)=O)=O)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
β-Glucuronide-NB-bis[N(Me)-methyl ester]-MMAE Related Classifications
HY-155313 Related Classifications
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