1-(2-Chloroacetyl)-3-(2,3-dimethylphenyl)urea
1-(2-Chloroacetyl)-3-(2,3-dimethylphenyl) urea is an anticancer agent. 1-(2-Chloroacetyl)-3-(2,3-dimethylphenyl) urea inhibits the growth of colon cancer, cutaneous melanoma and breast cancer. 1-(2-Chloroacetyl)-3-(2,3-dimethylphenyl) urea can be used in the research of colon cancer, cutaneous melanoma and breast cancer.
For research use only. We do not sell to patients.
- CAS No.: 871544-55-7
- Formula: C11H13ClN2O2
- Molecular Weight:240.69
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HT-29 | GI50 |
6 μM
Compound: 4e
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Growth inhibition of human HT29 cells after 48 hrs
Growth inhibition of human HT29 cells after 48 hrs
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[PMID: 17498960] |
| M21 | GI50 |
4.7 μM
Compound: 4e
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Growth inhibition of human M21 cells after 48 hrs
Growth inhibition of human M21 cells after 48 hrs
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[PMID: 17498960] |
| MCF7 | GI50 |
6.5 μM
Compound: 4e
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Growth inhibition of human MCF7 cells after 48 hrs
Growth inhibition of human MCF7 cells after 48 hrs
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[PMID: 17498960] |
In Vitro
1-(2-Chloroacetyl)-3-(2,3-dimethylphenyl)urea (0.3-10 μM; 48 h) inhibits the growth of HT-29 human colon carcinoma, M21 human skin melanoma, and MCF-7 human breast carcinoma cells with GI50 values in the 1.7 to 10 μM range[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
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Cell Line:HT-29 human colon carcinoma, M21 human skin melanoma, MCF-7 human breast carcinoma cells
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Concentration:0.3-10 μM
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Incubation Time:48 h
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Result:Exhibited antiproliferative activity with GI50 values between 4.7 and 6.5 μM across the three tumor cell lines.
Chemical Information
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CAS No. 871544-55-7
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Molecular Weight 240.69
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Formula C11H13ClN2O2
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SMILES
O=C(NC1=CC=CC(C)=C1C)NC(CCl)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocols
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Breast Cancer Modeling
Breast cancer is a heterogeneous cancer, and it has been distinguished into four subtypes: luminal A, luminal B, HER2-positive and basal-like. Molecular mutations, epigenetic alterations, hormone exposure and immune microenvironment are related to the progression of breast cancer.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
1-(2-Chloroacetyl)-3-(2,3-dimethylphenyl)urea Related Classifications
HY-184827 Related Classifications
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