1,2-Dimyristoyl-sn-glycero-3-phosphoserine  (Synonyms: DMPS)

1,2-Dimyristoyl-sn-glycero-3-phosphoserine (DMPS) is an anionic, negatively charged phosphatidylserine phospholipid. 1,2-Dimyristoyl-sn-glycero-3-phosphoserine acts as an internal standard for liquid chromatography/mass spectrometry analyses^[1][2].

1,2-Dimyristoyl-sn-glycero-3-phosphoserine binds preferentially to myristoylated recoverin in the presence of calcium via electrostatic interactions mediated by the protein's N-terminal cluster of positive charges, with a maximum insertion pressure of 36.7 mN/m^[2].
1,2-Dimyristoyl-sn-glycero-3-phosphoserine exhibits a selectively observed calcium-myristoyl switch of myristoylated recoverin upon binding to its monolayers, with Ca²⁺ increasing the maximum insertion pressure by 49.8% and driving preferential binding with a synergy value of 0.6^[2].
1,2-Dimyristoyl-sn-glycero-3-phosphoserine is specifically bound by myristoylated recoverin in the presence of calcium²⁺ in phospholipid monolayers, regardless of DMPS's physical state^[2].
1,2-Dimyristoyl-sn-glycero-3-phosphoserine is slightly penetrated by myristoylated recoverin in the presence of calcium²⁺ into its phospholipid monolayers, rather than binding only at the monolayer's aqueous interface^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

679.87

C₃₄H₆₆NO₁₀P

64023-32-1

[C@@H](COP(OC[C@@H](C(O)=O)N)(=O)O)(OC(CCCCCCCCCCCCC)=O)COC(CCCCCCCCCCCCC)=O

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Ju KY, et al. Highly water-dispersible composition having high ceramide content. Korea, WO2024210692 A. 2024-10-10.
  

  [2]. Calvez P, et al. Phosphatidylserine Allows Observation of the Calcium-Myristoyl Switch of Recoverin and Its Preferential Binding. J Am Chem Soc. 2016;138(41):13533-13540.  [Content Brief]