2. Cell Cycle/DNA Damage
  3. Nucleoside Antimetabolite/Analog
  4. 2-Amino-9-β-D-ribofuranosylpurine

2-Amino-9-β-D-ribofuranosylpurine  (Synonyms: 9-Pentofuranosyl-9H-purin-2-amine)

Art. -Nr.: HY-W354252 Reinheit: 99.71%
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(2R,3R,4S,5R)-2-(2-amino-9H-purin-9-yl)-5-(hydroxymethyl)tetrahydrofuran-3,4-diol (9-pentofuranosyl-9H-purin-2-amine) is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.

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2-Amino-9-β-D-ribofuranosylpurine

2-Amino-9-β-D-ribofuranosylpurine Chemische Struktur

CAS. Nr. : 4546-54-7

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Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 Auf Lager
Solution
10 mM * 1 mL in DMSO Auf Lager
Solid
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2-Amino-9-β-D-ribofuranosylpurine Related Antibodies

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Beschreibung

(2R,3R,4S,5R)-2-(2-amino-9H-purin-9-yl)-5-(hydroxymethyl)tetrahydrofuran-3,4-diol (9-pentofuranosyl-9H-purin-2-amine) is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].

Molekulargewicht

267.24

Formel

C10H13N5O4
CAS. Nr.
Appearance

Solid

Color

White to off-white

SMILES

O[C@@H]1[C@H](O)[C@@H](CO)O[C@H]1N2C=NC3=CN=C(N)N=C32
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Lösungsmittel & Löslichkeit
In Vitro: 

DMSO : 50 mg/mL (187.10 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.7420 mL 18.7098 mL 37.4195 mL
5 mM 0.7484 mL 3.7420 mL 7.4839 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molaritätsrechner

  • Verdünnungsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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(per animal)

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Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Reinheit & Dokumentation
Verweise

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.7420 mL 18.7098 mL 37.4195 mL 93.5489 mL
5 mM 0.7484 mL 3.7420 mL 7.4839 mL 18.7098 mL
10 mM 0.3742 mL 1.8710 mL 3.7420 mL 9.3549 mL
15 mM 0.2495 mL 1.2473 mL 2.4946 mL 6.2366 mL
20 mM 0.1871 mL 0.9355 mL 1.8710 mL 4.6774 mL
25 mM 0.1497 mL 0.7484 mL 1.4968 mL 3.7420 mL
30 mM 0.1247 mL 0.6237 mL 1.2473 mL 3.1183 mL
40 mM 0.0935 mL 0.4677 mL 0.9355 mL 2.3387 mL
50 mM 0.0748 mL 0.3742 mL 0.7484 mL 1.8710 mL
60 mM 0.0624 mL 0.3118 mL 0.6237 mL 1.5591 mL
80 mM 0.0468 mL 0.2339 mL 0.4677 mL 1.1694 mL
100 mM 0.0374 mL 0.1871 mL 0.3742 mL 0.9355 mL
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2-Amino-9-β-D-ribofuranosylpurine Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

2-Amino-9-β-D-ribofuranosylpurine4546-54-79-Pentofuranosyl-9H-purin-2-amineNucleoside Antimetabolite/Analogindolent lymphoid malignanciesantitumorInhibitorinhibitorinhibit

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