2-O-(p-Nitrophenyl)-α-D-N-acetylneuraminic acid
2-O-(p-Nitrophenyl)-α-D-N-acetylneuraminic acid (PNP-α-NeuNAc) is a classic chromogenic substrate for neuraminidase. 2-O-(p-Nitrophenyl)-α-D-N-acetylneuraminic acid releases p-nitrophenol upon enzymatic hydrolysis, allowing quantification of enzyme activity and inhibitory effects via spectrophotometry. 2-O-(p-Nitrophenyl)-α-D-N-acetylneuraminic acid (PNP-α-NeuNAc) acts as a sialyl donor in the process of enzyme-catalyzed trans-sialylation.
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- CAS No.: 26112-88-9
- Formula: C17H22N2O11
- Molecular Weight:430.36
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
In Vitro
Chemical Information
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CAS No. 26112-88-9
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Molecular Weight 430.36
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Formula C17H22N2O11
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SMILES
O=C([C@@]1(OC2=CC=C([N+]([O-])=O)C=C2)C[C@H](O)[C@@H](NC(C)=O)[C@H]([C@H](O)[C@H](O)CO)O1)O
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Synonyms
PNP-α-NeuNAc
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Hľasová Z, et al. Methods and Current Trends in Determination of Neuraminidase Activity and Evaluation of Neuraminidase Inhibitors. Crit Rev Anal Chem. 2019;49(4):350-367. [Content Brief]
[2]. Guo Y, et al. A Pasteurella multocida sialyltransferase displaying dual trans-sialidase activities for production of 3'-sialyl and 6'-sialyl glycans. J Biotechnol. 2014 Jan 20;170:60-7. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
2-O-(p-Nitrophenyl)-α-D-N-acetylneuraminic acid Related Classifications
HY-137878 Related Classifications
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