2. PROTAC
  3. PROTAC Linkers
  4. 3-Mercaptopropionic acid NHS ester

NHS ester  (Synonyms: 3-Mercaptopropionic acid NHS ester)

製品番号: HY-136159 純度: 95.0%
COA 取扱説明書 Technical Support

3-Mercaptopropanyl-N-hydroxysuccinimide ester is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs.

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3-Mercaptopropionic acid NHS ester

NHS ester 構造式

CAS 番号 : 117235-10-6

容量 価格（税別） 在庫状況 数量
100 mg $25 在庫あり
500 mg $60 在庫あり
1 g   お問い合わせ  
5 g   お問い合わせ  

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Based on 1 publication(s) in Google Scholar

NHS ester 関連抗体

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PEG Linkers Alkyl-Chain Linkers Alkyl/ether Linkers

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製品説明

3-Mercaptopropanyl-N-hydroxysuccinimide ester is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs[1].

IC50 & Target

Alkyl/ether

 

体外実験

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

NHS ester 関連抗体
分子量

203.22

分子式

C7H9NO4S
CAS 番号
Appearance

Liquid (Density: 1.40±0.1 g/cm3)

Color

Colorless to light yellow

SMILES

O=C(ON1C(CCC1=O)=O)CCS
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
溶剤 & 溶解度
体外: 

DMSO : 100 mg/mL (492.08 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.9208 mL 24.6039 mL 49.2078 mL
5 mM 0.9842 mL 4.9208 mL 9.8416 mL
10 mM 0.4921 mL 2.4604 mL 4.9208 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始）

C1

×
体積 （開始）

V1

=
濃度 （終了）

C2

×
体積 （終了）

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
純度とドキュメンテーション

純度: ≥97.0%

COA (249 KB) HNMR (267 KB) MS (78 KB)

取扱説明書 (2659 KB)
参考文献

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 4.9208 mL 24.6039 mL 49.2078 mL 123.0194 mL
5 mM 0.9842 mL 4.9208 mL 9.8416 mL 24.6039 mL
10 mM 0.4921 mL 2.4604 mL 4.9208 mL 12.3019 mL
15 mM 0.3281 mL 1.6403 mL 3.2805 mL 8.2013 mL
20 mM 0.2460 mL 1.2302 mL 2.4604 mL 6.1510 mL
25 mM 0.1968 mL 0.9842 mL 1.9683 mL 4.9208 mL
30 mM 0.1640 mL 0.8201 mL 1.6403 mL 4.1006 mL
40 mM 0.1230 mL 0.6151 mL 1.2302 mL 3.0755 mL
50 mM 0.0984 mL 0.4921 mL 0.9842 mL 2.4604 mL
60 mM 0.0820 mL 0.4101 mL 0.8201 mL 2.0503 mL
80 mM 0.0615 mL 0.3075 mL 0.6151 mL 1.5377 mL
100 mM 0.0492 mL 0.2460 mL 0.4921 mL 1.2302 mL
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3-Mercaptopropionic acid NHS ester Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質量   濃度   体積   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

3-Mercaptopropionic acid NHS ester117235-10-6PROTAC LinkersInhibitorinhibitorinhibit

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製品名:
3-Mercaptopropionic acid NHS ester
製品番号:
HY-136159
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