3’-β-C-Ethynylguanosine
3’-β-C-Ethynylguanosine is a guanosine analog. Some guanosine analogs have immunostimulatory activity. In some animal models, they also induce type I interferons, producing antiviral effects. Studies have shown that the functional activity of guanosine analogs is dependent on the activation of Toll-like receptor 7 (TLR7). 3’-β-C-Ethynylguanosine is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
For research use only. We do not sell to patients.
- CAS No.: 180300-56-5
- Formula: C12H13N5O5
- Molecular Weight:307.26
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| KB | IC50 |
>300 μM
Compound: EGuo(17)
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In vitro tumor cell growth inhibitory activity against human nasopharyngeal KB cell lines
In vitro tumor cell growth inhibitory activity against human nasopharyngeal KB cell lines
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[PMID: 8960561] |
| L1210 | IC50 |
>300 μM
Compound: EGuo(17)
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In vitro tumor cell growth inhibitory activity against mouse leukemia L1210 cell lines.
In vitro tumor cell growth inhibitory activity against mouse leukemia L1210 cell lines.
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[PMID: 8960561] |
Chemical Information
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CAS No. 180300-56-5
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Molecular Weight 307.26
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Formula C12H13N5O5
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SMILES
OC[C@@H]1[C@](O)(C#C)[C@@H](O)[C@H](N2C=NC3=C2N=C(N)NC3=O)O1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88. [Content Brief]
[2]. Lee J, et al. Molecular basis for the immunostimulatory activity of guanine nucleoside analogs: activation of Toll-like receptor 7. Proc Natl Acad Sci U S A. 2003 May 27;100(11):6646-51. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
3’-β-C-Ethynylguanosine Related Classifications
HY-152478 Related Classifications
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