4-[2-(Trimethylsilyl)ethynyl]benzaldehyde
Based on 1 Customer Validation
4-[2-(Trimethylsilyl)ethynyl]benzaldehyde is a PROTAC linker that can be used in the synthesis of PROTACs.
For research use only. We do not sell to patients.
- CAS No.: 77123-57-0
- Formula: C12H14OSi
- Molecular Weight:202.33
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Storage:
4°C, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
![4-[2-(Trimethylsilyl)ethynyl]benzaldehyde Chemical Structure](https://file.medchemexpress.com/product_pic/hy-w086076.gif "Click to View 4-[2-(Trimethylsilyl)ethynyl]benzaldehyde Chemical Structure")
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
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Help & FAQs
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Biological Activity
Description
In Vitro
PROTACs contain two different ligands connected by a linker; one is a ligand for an E366 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. .
Chemical Information
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CAS No. 77123-57-0
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Appearance Solid
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Molecular Weight 202.33
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Formula C12H14OSi
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Color Off-white to light brown
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SMILES
O=CC1=CC=C(C#C[Si](C)(C)C)C=C1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
Solvent & Solubility
In Vitro:
DMSO : 100 mg/mL (494.24 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (240 KB)
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SDS (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 4.9424 mL | 24.7121 mL | 49.4242 mL | 123.5605 mL |
| 5 mM | 0.9885 mL | 4.9424 mL | 9.8848 mL | 24.7121 mL | |
| 10 mM | 0.4942 mL | 2.4712 mL | 4.9424 mL | 12.3561 mL | |
| 15 mM | 0.3295 mL | 1.6475 mL | 3.2949 mL | 8.2374 mL | |
| 20 mM | 0.2471 mL | 1.2356 mL | 2.4712 mL | 6.1780 mL | |
| 25 mM | 0.1977 mL | 0.9885 mL | 1.9770 mL | 4.9424 mL | |
| 30 mM | 0.1647 mL | 0.8237 mL | 1.6475 mL | 4.1187 mL | |
| 40 mM | 0.1236 mL | 0.6178 mL | 1.2356 mL | 3.0890 mL | |
| 50 mM | 0.0988 mL | 0.4942 mL | 0.9885 mL | 2.4712 mL | |
| 60 mM | 0.0824 mL | 0.4119 mL | 0.8237 mL | 2.0593 mL | |
| 80 mM | 0.0618 mL | 0.3089 mL | 0.6178 mL | 1.5445 mL | |
| 100 mM | 0.0494 mL | 0.2471 mL | 0.4942 mL | 1.2356 mL |
4-[2-(Trimethylsilyl)ethynyl]benzaldehyde Related Classifications
HY-W086076 Related Classifications
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