4',6,7-Trimethoxyisoflavone
Based on 1 Customer Validation
4',6,7-Trimethoxyisoflavone is an isoflavone with antimicrobial activities against a wide range of bacteria and fungi. 4',6,7-Trimethoxyisoflavone also has antioxidant effects.
For research use only. We do not sell to patients.
- Purity : 97.04%
- CAS No.: 798-61-8
- Formula: C18H16O5
- Molecular Weight:312.32
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Storage:
Store at room temperature 3 years.
In solvent -80°C, 2 years , -20°C, 1 year
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Protocols
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
Cellular Effect
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Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| A-375 | IC50 |
>10 μM
Compound: 9ca
|
Growth inhibition of human A375 cells measured after 48 hrs by MTS assay
Growth inhibition of human A375 cells measured after 48 hrs by MTS assay
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[PMID: 27100701] |
| A549 | IC50 |
>10 μM
Compound: 9ca
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Growth inhibition of human A549 cells by MTS assay
Growth inhibition of human A549 cells by MTS assay
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[PMID: 27100701] |
| DU-145 | IC50 |
>10 μM
Compound: 9ca
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Growth inhibition of human DU145 cells measured after 48 hrs by MTS assay
Growth inhibition of human DU145 cells measured after 48 hrs by MTS assay
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[PMID: 27100701] |
| HCT-116 | IC50 |
>10 μM
Compound: 9ca
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Growth inhibition of human HCT116 cells measured after 48 hrs by MTS assay
Growth inhibition of human HCT116 cells measured after 48 hrs by MTS assay
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[PMID: 27100701] |
| MDA-MB-231 | IC50 |
>10 μM
Compound: 9ca
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Growth inhibition of human MDA-MB-231 cells measured after 48 hrs by MTS assay
Growth inhibition of human MDA-MB-231 cells measured after 48 hrs by MTS assay
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[PMID: 27100701] |
| PBMC | IC50 |
>10 μM
Compound: 9ca
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Growth inhibition of human PBMC cells measured after 48 hrs by MTS assay
Growth inhibition of human PBMC cells measured after 48 hrs by MTS assay
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[PMID: 27100701] |
| PC-3 | IC50 |
>10 μM
Compound: 9ca
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Growth inhibition of human PC3 cells measured after 48 hrs by MTS assay
Growth inhibition of human PC3 cells measured after 48 hrs by MTS assay
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[PMID: 27100701] |
| SK-OV-3 | IC50 |
>10 μM
Compound: 9ca
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Growth inhibition of human SKOV3 cells measured after 48 hrs by MTS assay
Growth inhibition of human SKOV3 cells measured after 48 hrs by MTS assay
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[PMID: 27100701] |
Chemical Information
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CAS No. 798-61-8
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Appearance Solid
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Molecular Weight 312.32
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Formula C18H16O5
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Color Off-white to light yellow
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SMILES
O=C1C(C2=CC=C(OC)C=C2)=COC3=CC(OC)=C(OC)C=C13
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Structure Classification
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Store at room temperature 3 years
In solvent -80°C 2 years -20°C 1 year
Solvent & Solubility
In Vitro:
DMSO : 50 mg/mL (160.09 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Protocols
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Research Protocol for Infectious Diseases
Infectious-disease experiments test how pathogens interact with host barriers, innate immune receptors, inflammatory signaling, pathogen replication, and tissue injury; pattern-recognition receptors such as TLRs, RIG-I-like receptors, NOD-like receptors, and inflammasomes detect microbial molecules and activate NF-κB, interferon, and cytokine responses. The central hypothesis is that infection severity reflects the balance between pathogen burden and host response: protective inflammation restricts pathogen growth, whereas excessive or mislocalized inflammation contributes to tissue damage and disease phenotype. Unresolved questions include which host pathways are protective versus pathogenic, why some infection models fail to translate to human disease, and which combined readouts best predict clinically relevant infection outcomes.
Purity & Documentation
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Data Sheet (268 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.2018 mL | 16.0092 mL | 32.0184 mL | 80.0461 mL |
| 5 mM | 0.6404 mL | 3.2018 mL | 6.4037 mL | 16.0092 mL | |
| 10 mM | 0.3202 mL | 1.6009 mL | 3.2018 mL | 8.0046 mL | |
| 15 mM | 0.2135 mL | 1.0673 mL | 2.1346 mL | 5.3364 mL | |
| 20 mM | 0.1601 mL | 0.8005 mL | 1.6009 mL | 4.0023 mL | |
| 25 mM | 0.1281 mL | 0.6404 mL | 1.2807 mL | 3.2018 mL | |
| 30 mM | 0.1067 mL | 0.5336 mL | 1.0673 mL | 2.6682 mL | |
| 40 mM | 0.0800 mL | 0.4002 mL | 0.8005 mL | 2.0012 mL | |
| 50 mM | 0.0640 mL | 0.3202 mL | 0.6404 mL | 1.6009 mL | |
| 60 mM | 0.0534 mL | 0.2668 mL | 0.5336 mL | 1.3341 mL | |
| 80 mM | 0.0400 mL | 0.2001 mL | 0.4002 mL | 1.0006 mL | |
| 100 mM | 0.0320 mL | 0.1601 mL | 0.3202 mL | 0.8005 mL |
4',6,7-Trimethoxyisoflavone Related Classifications
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