6-Hydroxy-7-methoxy-2-[2-(4-methoxyphenyl)ethyl]chromone
6-Hydroxy-7-methoxy-2-[2-(4-methoxyphenyl) ethyl]chromone is a 2-(2-phenylethyl) chromone derivative that can be isolated and extracted from Gyrinops salicifolia Ridl. 6-Hydroxy-7-methoxy-2-[2-(4-methoxyphenyl) ethyl]chromone exhibits antitumor activity. 6-Hydroxy-7-methoxy-2-[2-(4-methoxyphenyl) ethyl]chromone can be used in research on myeloid leukemia, hepatocellular carcinoma, and gastric cancer.
For research use only. We do not sell to patients.
- CAS No.: 2170997-55-2
- Formula: C19H18O5
- Molecular Weight:326.34
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
![6-Hydroxy-7-methoxy-2-[2-(4-methoxyphenyl)ethyl]chromone Chemical Structure](https://file.medchemexpress.com/product_pic/hy-n22063.gif "Click to View 6-Hydroxy-7-methoxy-2-[2-(4-methoxyphenyl)ethyl]chromone Chemical Structure")
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
All Endogenous Metabolite Isoforms
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Biological Activity
Description
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| SGC-7901 | IC50 |
17.8 μM
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Cytotoxicity against human gastric carcinoma SGC-7901 cells assessed as reduction in cell viability by MTT assay.
Cytotoxicity against human gastric carcinoma SGC-7901 cells assessed as reduction in cell viability by MTT assay.
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molecules21101313 |
| K562 | IC50 |
13.9 μM
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Cytotoxicity against human myeloid leukemia K562 cells assessed as reduction in cell viability by MTT assay.
Cytotoxicity against human myeloid leukemia K562 cells assessed as reduction in cell viability by MTT assay.
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molecules21101313 |
| Bel-7402 | IC50 |
31.9 μM
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Cytotoxicity against human hepatocellular carcinoma BEL-7402 cells assessed as reduction in cell viability by MTT assay.
Cytotoxicity against human hepatocellular carcinoma BEL-7402 cells assessed as reduction in cell viability by MTT assay.
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molecules21101313 |
In Vitro
6-Hydroxy-7-methoxy-2-[2-(4-methoxyphenyl) ethyl]chromone (compound 2) exhibited moderate cytotoxicity against SGC-7901 and K562 cells and weak cytotoxicity against BEL-7402 cells, with IC50 values of 17.8, 13.9, and 31.9 μM, respectively[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
Chemical Information
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CAS No. 2170997-55-2
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Molecular Weight 326.34
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Formula C19H18O5
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SMILES
OC(C=C1C(OC(CCC2=CC=C(C=C2)OC)=CC1=O)=C3)=C3OC
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocols
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Liver Cancer Modeling
Liver cancer can be classified into primary liver cancer and secondary liver cancer. Secondary liver cancer is the metastatic liver cancer. Primary liver cancer includes hepatocellular carcinoma (HCC), intrahepatic cholangiocarcinoma (ICC) and fibrolamellar HCC, of which HCC is the most common form, accounting for approximately 90% of primary liver cancers[1]. HCC mouse models include chemical agent-induced models, transplanted tumor models, and genetic engineered models.
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Subcutaneous Cell-Line-Derived Xenograft
Subcutaneous cell-line-derived xenograft (CDX) models are established by implanting cultured human cancer cell lines into immunodeficient mice, where the injected cells form localized tumors that can be monitored in vivo as a measure of tumorigenic potential, growth kinetics, and treatment response. These models are widely used in oncology research because they allow reproducible tumor formation and enable comparative assessment of tumor growth between different cell lines or genetic manipulations in a controlled in vivo microenvironment. Subcutaneous implantation of cancer cells in immunodeficient mice is a standard approach for evaluating tumor growth behavior and therapeutic response across multiple cancer types, including prostate, esophageal, pancreatic, and colon cancer models.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
6-Hydroxy-7-methoxy-2-[2-(4-methoxyphenyl)ethyl]chromone Related Classifications
HY-N22063 Related Classifications
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