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6β,7β-Epoxyasteriscunolide A

6β,7β-Epoxyasteriscunolide A, a sesquiterpenoid, shows cytotoxicity against the HL-60 and MOLT-3 leukemia cell lines, with IC₅₀s range 4.1-5.4 μM.

For research use only. We do not sell to patients.

CAS No.: 1927017-53-5
Formula: C₁₅H₁₈O₄
Molecular Weight:262.30

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (276 KB)

6β,7β-Epoxyasteriscunolide A Chemical Structure

CAS No.: 1927017-53-5

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Biological Activity
- Description
- Cellular Effect
Chemical Information
Purity & Documentation
References
Calculators
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Biological Activity

Description

6β,7β-Epoxyasteriscunolide A, a sesquiterpenoid, shows cytotoxicity against the HL-60 and MOLT-3 leukemia cell lines, with IC₅₀s range 4.1-5.4 μM^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
A549	IC₅₀	3.02 μM Compound: 11; HAE	Antiproliferative activity against human A549 cells incubated for 24 hrs by MTT assay Antiproliferative activity against human A549 cells incubated for 24 hrs by MTT assay	[PMID: 35093502]
Ca9-22	IC₅₀	2.94 μM Compound: 11; HAE	Antiproliferative activity against human Ca9-22 cells incubated for 24 hrs by MTT assay Antiproliferative activity against human Ca9-22 cells incubated for 24 hrs by MTT assay	[PMID: 35093502]
CHL-1	IC₅₀	3.63 μM Compound: 11; HAE	Antiproliferative activity against human CHL-1 cells incubated for 24 hrs by MTT assay Antiproliferative activity against human CHL-1 cells incubated for 24 hrs by MTT assay	[PMID: 35093502]
HCT-116	IC₅₀	1.22 μM Compound: 11; HAE	Antiproliferative activity against human HCT-116 cells incubated for 24 hrs by MTT assay Antiproliferative activity against human HCT-116 cells incubated for 24 hrs by MTT assay	[PMID: 35093502]
HeLa	IC₅₀	4.78 μM Compound: 11; HAE	Antiproliferative activity against human HeLa cells incubated for 24 hrs by MTT assay Antiproliferative activity against human HeLa cells incubated for 24 hrs by MTT assay	[PMID: 35093502]
HL-60	IC₅₀	5.4 μM Compound: 1	Cytotoxicity against human HL60 cells assessed as cell growth inhibition after 72 hrs by MTT assay Cytotoxicity against human HL60 cells assessed as cell growth inhibition after 72 hrs by MTT assay	[PMID: 27145162]
HT-1080	IC₅₀	6.54 μM Compound: 11; HAE	Antiproliferative activity against human HT-1080 cells incubated for 24 hrs by MTT assay Antiproliferative activity against human HT-1080 cells incubated for 24 hrs by MTT assay	[PMID: 35093502]
MOLT-3	IC₅₀	4.1 μM Compound: 1	Cytotoxicity against human MOLT3 cells assessed as cell growth inhibition after 72 hrs by MTT assay Cytotoxicity against human MOLT3 cells assessed as cell growth inhibition after 72 hrs by MTT assay	[PMID: 27145162]
PC-3	IC₅₀	1.81 μM Compound: 11; HAE	Antiproliferative activity against human PC-3 cells incubated for 24 hrs by MTT assay Antiproliferative activity against human PC-3 cells incubated for 24 hrs by MTT assay	[PMID: 35093502]
SK-MEL-28	IC₅₀	3.43 μM Compound: 11; HAE	Antiproliferative activity against human SK-MEL-28 cells incubated for 24 hrs by MTT assay Antiproliferative activity against human SK-MEL-28 cells incubated for 24 hrs by MTT assay	[PMID: 35093502]

Chemical Information

CAS No. 1927017-53-5
Molecular Weight 262.30
Formula C₁₅H₁₈O₄
SMILES

[H][C@]12C=C(C(O2)=O)CC[C@@H]3O[C@@]3(C(/C=C/C1(C)C)=O)C
Structure Classification
- Ketones, Aldehydes, Acids
Initial Source
- Plants
- other families
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (276 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Triana J, et al. Sesquiterpenoids Isolated from Two Species of the Asteriscus Alliance. J Nat Prod. 2016;79(5):1292-1297. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biological Activity
- Description
Chemical Information
Purity & Documentation
References

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