7-Aminomethyl-10-methyl-11-fluoro camptothecin TFA

Cat. No.: HY-132160A Purity: 96.52%: Data Sheet
COA

SDS
Handling Instructions
FAQs
Technical Support

7-Aminomethyl-10-methyl-11-fluoro camptothecin TFA is a cytotoxin of MC-AAA-NHCH2OCH2COO-7-aminomethyl-10-methyl-11-fluoro camptothecin (HY-132158). 7-Aminomethyl-10-methyl-11-fluoro camptothecin TFA can be used for the synthesis of camptothecin antibody-drug conjugate (ADC).

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

7-Aminomethyl-10-methyl-11-fluoro camptothecin TFA 화학구조

사이즈	재고	수량
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	해외재고보유	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	해외재고보유	Estimated Time of Arrival: December 31
Solid
1 mg	해외재고보유	Estimated Time of Arrival: December 31
5 mg	해외재고보유	Estimated Time of Arrival: December 31
10 mg	해외재고보유	Estimated Time of Arrival: December 31
25 mg	해외재고보유	Estimated Time of Arrival: December 31
50 mg	해외재고보유	Estimated Time of Arrival: December 31
100 mg	견적 받기
200 mg	견적 받기

or 대량구매 문의

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

This product is a controlled substance and not for sale in your territory.

고객리뷰

Based on 1 Customer Validation

Other Forms of 7-Aminomethyl-10-methyl-11-fluoro camptothecin TFA:

7-Aminomethyl-10-methyl-11-fluoro camptothecin In-stock

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Biological Activity
순도&문서
References
고객리뷰

제품 설명

분자량

523.43

화학식

C₂₄H₂₁F₄N₃O₆

Appearance

Solid

Color

Light yellow to yellow

SMILES

NCC1=C2C(C(N3C2)=CC([C@]4(CC)O)=C(C3=O)COC4=O)=NC5=CC(F)=C(C=C51)C.OC(C(F)(F)F)=O

선적

Room temperature in continental US; may vary elsewhere.

보관

-20°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

용액&용해도

In Vitro:

DMSO : 25 mg/mL (47.76 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.9105 mL	9.5524 mL	19.1048 mL
5 mM	0.3821 mL	1.9105 mL	3.8210 mL
10 mM	0.1910 mL	0.9552 mL	1.9105 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

몰농도 계산기
농도 희석 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

순도&문서

Purity: 96.52%

Select Batch:

Data Sheet (269 KB) SDS (252 KB)

COA (250 KB) HNMR (420 KB) LCMS (101 KB)

Handling Instructions (2659 KB)

References

[1]. Li W, et, al. Synthesis and Evaluation of Camptothecin Antibody-Drug Conjugates. ACS Med Chem Lett. 2019 Sep 6;10(10):1386-1392. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.9105 mL	9.5524 mL	19.1048 mL	47.7619 mL
	5 mM	0.3821 mL	1.9105 mL	3.8210 mL	9.5524 mL
	10 mM	0.1910 mL	0.9552 mL	1.9105 mL	4.7762 mL
	15 mM	0.1274 mL	0.6368 mL	1.2737 mL	3.1841 mL
	20 mM	0.0955 mL	0.4776 mL	0.9552 mL	2.3881 mL
	25 mM	0.0764 mL	0.3821 mL	0.7642 mL	1.9105 mL
	30 mM	0.0637 mL	0.3184 mL	0.6368 mL	1.5921 mL
	40 mM	0.0478 mL	0.2388 mL	0.4776 mL	1.1940 mL