(7RS)-Nivegacetor
Based on 1 Customer Validation
(7RS)-Nivegacetor is the racemate of Nivegacetor (HY-159836). Nivegacetor is a potent and selective γ-secretase modulator. It reduces Aβ42 production and can be used in Alzheimer's disease research.
For research use only. We do not sell to patients.
- Formula: C23H25F2N7O2
- Molecular Weight:469.49
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Storage:
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Chemical Information
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Appearance Solid
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Molecular Weight 469.49
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Formula C23H25F2N7O2
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SMILES
[H][C@@]1(CC2)CN(C3=CN=NC(OC)=C3)C[C@@]2([H])[C@@H]1NC4=NN(CCC5OC6=CC(F)=CC(F)=C6)C5=N4
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Synonyms
(7RS)-RG6289
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Solvent & Solubility
DMSO : 100 mg/mL (213.00 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
References
[1]. Tariot P N, et al. Safety and efficacy of crenezumab in cognitively unimpaired carriers of the PSEN1Glu280Ala mutation at risk for autosomal-dominant Alzheimer's disease in Colombia (API ADAD Colombia Trial): a phase 2, randomised, double-blind, placebo-controlled trial[J]. The Lancet Neurology, 2026, 25(2): 147-159. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.1300 mL | 10.6499 mL | 21.2997 mL | 53.2493 mL |
| 5 mM | 0.4260 mL | 2.1300 mL | 4.2599 mL | 10.6499 mL | |
| 10 mM | 0.2130 mL | 1.0650 mL | 2.1300 mL | 5.3249 mL | |
| 15 mM | 0.1420 mL | 0.7100 mL | 1.4200 mL | 3.5500 mL | |
| 20 mM | 0.1065 mL | 0.5325 mL | 1.0650 mL | 2.6625 mL | |
| 25 mM | 0.0852 mL | 0.4260 mL | 0.8520 mL | 2.1300 mL | |
| 30 mM | 0.0710 mL | 0.3550 mL | 0.7100 mL | 1.7750 mL | |
| 40 mM | 0.0532 mL | 0.2662 mL | 0.5325 mL | 1.3312 mL | |
| 50 mM | 0.0426 mL | 0.2130 mL | 0.4260 mL | 1.0650 mL | |
| 60 mM | 0.0355 mL | 0.1775 mL | 0.3550 mL | 0.8875 mL | |
| 80 mM | 0.0266 mL | 0.1331 mL | 0.2662 mL | 0.6656 mL | |
| 100 mM | 0.0213 mL | 0.1065 mL | 0.2130 mL | 0.5325 mL |
(7RS)-Nivegacetor Related Classifications
HY-159836A Related Classifications
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