country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Country or Region:

United States

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

Cat. No.: HY-163330

Copy Link Print Information

8-Azakinetin riboside

8-Azakinetin riboside is a structural analog of kinetin riboside. Azakinetin riboside shows cytotoxic activity.

For research use only. We do not sell to patients.

CAS No.: 2347524-00-7
Formula: C₁₄H₁₆N₆O₅
Molecular Weight:348.31

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (271 KB)

8-Azakinetin riboside Chemical Structure

CAS No.: 2347524-00-7

Size

Price

Stock

Quantity

Amount: USD 0.00

* Please select Quantity before adding items.

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

8-Azakinetin riboside is a structural analog of kinetin riboside. Azakinetin riboside shows cytotoxic activity^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
Caco-2	IC₅₀	11.5 μM Compound: 7; 8-azaKR	Cytotoxicity against human Caco-2 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay Cytotoxicity against human Caco-2 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay	[PMID: 38280656]
Caco-2	IC₅₀	18.7 μM Compound: 7; 8-azaKR	Cytotoxicity against human Caco-2 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay Cytotoxicity against human Caco-2 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay	[PMID: 38280656]
Caco-2	IC₅₀	25 μM Compound: 7; 8-azaKR	Cytotoxicity against human Caco-2 cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay Cytotoxicity against human Caco-2 cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay	[PMID: 38280656]
HeLa	IC₅₀	>100 μM Compound: 7; 8-azaKR	Cytotoxicity against human HeLa cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay Cytotoxicity against human HeLa cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay	[PMID: 38280656]
HeLa	IC₅₀	14.5 μM Compound: 7; 8-azaKR	Cytotoxicity against human HeLa cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay Cytotoxicity against human HeLa cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay	[PMID: 38280656]
HeLa	IC₅₀	4.6 μM Compound: 7; 8-azaKR	Cytotoxicity against human HeLa cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay Cytotoxicity against human HeLa cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay	[PMID: 38280656]
MCF7	IC₅₀	27 μM Compound: 7; 8-azaKR	Cytotoxicity against human MCF7 cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay Cytotoxicity against human MCF7 cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay	[PMID: 38280656]
MCF7	IC₅₀	3.8 μM Compound: 7; 8-azaKR	Cytotoxicity against human MCF7 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay Cytotoxicity against human MCF7 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay	[PMID: 38280656]
MCF7	IC₅₀	4.3 μM Compound: 7; 8-azaKR	Cytotoxicity against human MCF7 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay Cytotoxicity against human MCF7 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay	[PMID: 38280656]
MIA PaCa-2	IC₅₀	>100 μM Compound: 7; 8-azaKR	Cytotoxicity against human MIA PaCa-2 cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay Cytotoxicity against human MIA PaCa-2 cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay	[PMID: 38280656]
MIA PaCa-2	IC₅₀	1.1 μM Compound: 7; 8-azaKR	Cytotoxicity against human MIA PaCa-2 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay Cytotoxicity against human MIA PaCa-2 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay	[PMID: 38280656]
MIA PaCa-2	IC₅₀	2.8 μM Compound: 7; 8-azaKR	Cytotoxicity against human MIA PaCa-2 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay Cytotoxicity against human MIA PaCa-2 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay	[PMID: 38280656]
MRC5	IC₅₀	>100 μM Compound: 7; 8-azaKR	Cytotoxicity against human MRC5 cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay Cytotoxicity against human MRC5 cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay	[PMID: 38280656]
MRC5	IC₅₀	11.7 μM Compound: 7; 8-azaKR	Cytotoxicity against human MRC5 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay Cytotoxicity against human MRC5 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay	[PMID: 38280656]
MRC5	IC₅₀	4.6 μM Compound: 7; 8-azaKR	Cytotoxicity against human MRC5 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay Cytotoxicity against human MRC5 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay	[PMID: 38280656]
OVCAR-3	IC₅₀	>100 μM Compound: 7; 8-azaKR	Cytotoxicity against human OVCAR-3 cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay Cytotoxicity against human OVCAR-3 cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay	[PMID: 38280656]
OVCAR-3	IC₅₀	1.1 μM Compound: 7; 8-azaKR	Cytotoxicity against human OVCAR-3 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay Cytotoxicity against human OVCAR-3 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay	[PMID: 38280656]
OVCAR-3	IC₅₀	76 μM Compound: 7; 8-azaKR	Cytotoxicity against human OVCAR-3 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay Cytotoxicity against human OVCAR-3 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay	[PMID: 38280656]

In Vitro

Azakinetin riboside (compound 7) (0-100 μM; 24, 48, 72 h) shows cytotoxic activity for HeLaWT, MCF7, Caco-2, OVCAR-3, MIAPaCa-2, MRC-5 cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cytotoxicity Assay^[1]

Cell Line:

HeLaWT, MCF7, Caco-2, OVCAR-3, MIAPaCa-2, MRC-5 cells
Concentration:

0-100 µM
Incubation Time:

24, 48, 72 h
Result:

Showed cytotoxic activity for HeLaWT, MCF7, Caco-2, OVCAR-3, MIAPaCa-2, MRC-5 cells with IC₅₀s of >100, 27, 25, >100, >100, >100 µM at 24 h, 14.5, 4.3, 18.7, 76, 2.8, 11.7 at 48 h, 4.6, 3.8, 11.5, 1.1, 1.1, 4.6 µM at 72 h, respectively.

Chemical Information

CAS No. 2347524-00-7
Molecular Weight 348.31
Formula C₁₄H₁₆N₆O₅
SMILES

O[C@H]1[C@@H](O)[C@H](N2C(N=CN=C3NCC4=CC=CO4)=C3N=N2)O[C@@H]1CO
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (271 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Totoń E, et al. Cytotoxic effects of kinetin riboside and its selected analogues on cancer cell lines. Bioorg Med Chem Lett. 2024 Mar 1;100:129628. [Content Brief]

Calculators

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Dilution Calculator

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

MOQ

Minimum order quantity

100 mg

Get Quote In-stock

Other size

Get Quote