8-pCPT-2′-O-Me-cAMP sodium (Standard)
8-pCPT-2′-O-Me-cAMP sodium (Standard) is the analytical standard of 8-pCPT-2′-O-Me-cAMP (sodium) (HY-107543). This product is intended for research and analytical applications. 8-pCPT-2′-O-Me-cAMP (8-CPT-2'-O-Me-cAMP) sodium, an analog of cAMP, is an activator of exchange proteins activated by cAMP (Epac). 8-pCPT-2′-O-Me-cAMP sodium activates Epac1 (EC50 = 2.2 μM), but not PKA (EC50 >10 μM). 8-pCPT-2′-O-Me-cAMP sodium stimulates Epac-mediated Ca2+ release in pancreatic β-cells in vitro. 8-pCPT-2′-O-Me-cAMP sodium is a Rap1 activator. 8-pCPT-2′-O-Me-cAMP sodium enhances the retinal pigment epithelium barrier against the pathological choroidal endothelial cell invasion that occurs in macular degeneration.
For research use only. We do not sell to patients.
- CAS No.: 634207-53-7
- Formula: C17H16ClN5NaO6PS
- Molecular Weight:507.82
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Product Information
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Chemical Information
- Purity & Documentation
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Help & FAQs
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HY-107543
8-pCPT-2′-O-Me-cAMP sodium -
HY-101379A
8-Bromo-cGMP sodium -
HY-107545
Dynole 34-2 -
HY-D0839
Tetradecyltrimethylammonium bromide -
HY-W013158
Trimethyloctadecylammonium bromide -
HY-B0764
Bucladesine sodium -
HY-12306
8-Bromo-cAMP sodium salt -
HY-131768
2'-O-Succinyl-cAMP -
HY-107544
8-pCPT-2'-O-Me-cAMP-AM -
HY-101325
(S,S)-BRL-37344 sodium -
HY-15702
HJC0350 -
HY-103322
6-Bnz-cAMP sodium salt
Product Information
Information
Application
The compound is the grade of analytical standard, which is the reference standard supplied assay. It is commonly used in qualitative, quantitative and methodological research experiments in HPLC, GC and MS.
Chemical Information
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CAS No. 634207-53-7
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Molecular Weight 507.82
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Formula C17H16ClN5NaO6PS
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SMILES
NC1=C2C(N([C@H]3[C@@H]([C@@](O4)([H])[C@](COP4(O[Na])=O)([H])O3)OC)C(SC5=CC=C(Cl)C=C5)=N2)=NC=N1
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Synonyms
8-CPT-2'-O-Me-cAMP sodium (Standard)
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Wittchen ES, et al. Rap1 GTPase activation and barrier enhancement in rpe inhibits choroidal neovascularization in vivo. PLoS One. 2013 Sep 10;8(9):e73070. [Content Brief]
[2]. Enserink JM, Christensen AE, de Rooij J, van Triest M, Schwede F, Genieser HG, Døskeland SO, Blank JL, Bos JL. A novel Epac-specific cAMP analogue demonstrates independent regulation of Rap1 and ERK. Nat Cell Biol. 2002 Nov;4(11):901-6. [Content Brief]
[3]. Kang G, Joseph JW, Chepurny OG, Monaco M, Wheeler MB, Bos JL, Schwede F, Genieser HG, Holz GG. Epac-selective cAMP analog 8-pCPT-2'-O-Me-cAMP as a stimulus for Ca2+-induced Ca2+ release and exocytosis in pancreatic beta-cells. J Biol Chem. 2003 Mar 7;278. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
8-pCPT-2′-O-Me-cAMP sodium (Standard) Related Classifications
HY-107543R Related Classifications
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