Ubavitinib tosylate
Based on 1 Customer Validation
AZD3229 Tosylate is a potent pan-KIT mutant inhibitor for the treatment of gastrointestinal stromal tumors.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度 : 98.83%
- CAS 番号: 2248003-71-4
- 分子式: C31H34FN7O6S
- 分子量:651.71
-
保管条件:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
生物活性
-
化学情報
-
溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
-
Help & FAQs
-
HY-101443
ISCK03SCF/c-Kit Inhibitor -
HY-112802
Ubavitinibc-Kit Inhibitor -
HY-101561
AvapritinibKIT/PDGFRA Inhibitor -
HY-145557
Bezuclastinibc-kit Inhibitor -
HY-15240
c-Kit-IN-1c-Kit/c-Met Inhibitor -
HY-10229
Motesanib DiphosphateVEGFR1/2/3 Inhibitor -
HY-16961
SitravatinibRTK Inhibitor -
HY-16749
PexidartinibCSF1R/c-Kit Inhibitor -
HY-10228
MotesanibVEGFR1/2/3 Inhibitor -
HY-10501
SU14813Multiple RTK Inhibitor -
HY-50946
Imatinib Mesylatec-Kit Inhibitor -
HY-152839
ElenestinibTyrosine Kinase Inhibitor
生物活性
製品説明
IC50 & Target
KIT[1].
体外実験
AZD3229 is a potent, pan-KIT mutant inhibitor with potent single digit nM growth inhibition against a diverse panel of mutant KIT driven Ba/F3 cell lines (GI50=1-50 nM). AZD3229 demonstrates potent single digit nM growth inhibition across a broad cell panel, with good margin to KDR-driven effects. Selectivity over KDR can be rationalised predominantly by the interaction of water molecules with the protein and ligand in the active site and its kinome selectivity is similar to the best of the approved GIST agents[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. .
化学情報
-
CAS 番号 2248003-71-4
-
性状 Solid
-
分子量 651.71
-
分子式 C31H34FN7O6S
-
Color Light yellow to yellow
-
SMILES
COCCOC1=CC(F)=C2C(N=CN=C2NC3=CC=C(NC(CN4C=C(C(C)C)N=N4)=O)C=C3)=C1.CC5=CC=C(S(O)(=O)=O)C=C5
-
別名
AZD3229 tosylate
-
輸送条件
Room temperature in continental US; may vary elsewhere.
-
保管条件
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
溶剤 & 溶解度
体外:
DMSO : ≥ 100 mg/mL (153.44 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
-
データシート (273 KB)
-
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
-
取扱説明書 (2659 KB)
参考文献
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.5344 mL | 7.6721 mL | 15.3442 mL | 38.3606 mL |
| 5 mM | 0.3069 mL | 1.5344 mL | 3.0688 mL | 7.6721 mL | |
| 10 mM | 0.1534 mL | 0.7672 mL | 1.5344 mL | 3.8361 mL | |
| 15 mM | 0.1023 mL | 0.5115 mL | 1.0229 mL | 2.5574 mL | |
| 20 mM | 0.0767 mL | 0.3836 mL | 0.7672 mL | 1.9180 mL | |
| 25 mM | 0.0614 mL | 0.3069 mL | 0.6138 mL | 1.5344 mL | |
| 30 mM | 0.0511 mL | 0.2557 mL | 0.5115 mL | 1.2787 mL | |
| 40 mM | 0.0384 mL | 0.1918 mL | 0.3836 mL | 0.9590 mL | |
| 50 mM | 0.0307 mL | 0.1534 mL | 0.3069 mL | 0.7672 mL | |
| 60 mM | 0.0256 mL | 0.1279 mL | 0.2557 mL | 0.6393 mL | |
| 80 mM | 0.0192 mL | 0.0959 mL | 0.1918 mL | 0.4795 mL | |
| 100 mM | 0.0153 mL | 0.0767 mL | 0.1534 mL | 0.3836 mL |
Ubavitinib tosylate 関連分類
HY-112802A 関連分類
Powered by Bioz