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Cat. No.: HY-107774

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BMS-986163

BMS-986163 is a negative allosteric modulator of GluN2B. The proagent BMS-986163 rapidly converts to its active parent molecule BMS-986169 (K_i=4 nM, IC₅₀=24 nM).

For research use only. We do not sell to patients.

CAS No.: 1801151-09-6
Formula: C₂₃H₂₈FN₂O₅P
Molecular Weight:462.45

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (266 KB)

BMS-986163 Chemical Structure

CAS No.: 1801151-09-6

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

BMS-986163 is a negative allosteric modulator of GluN2B. The proagent BMS-986163 rapidly converts to its active parent molecule BMS-986169 (K_i=4 nM, IC₅₀=24 nM).

IC₅₀ & Target

IC50: 24 nM (GluN2B, BMS-986169)^[1]

Ki: 4 nM (GluN2B, BMS-986169)^[1]

All iGluR Isoforms :

Chemical Information

CAS No. 1801151-09-6
Molecular Weight 462.45
Formula C₂₃H₂₈FN₂O₅P
SMILES

CC1=CC=C(CN2CC[C@@H](N3C[C@@H](F)[C@H](C4=CC=C(OP(O)(O)=O)C=C4)CC3)C2=O)C=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (266 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Marcin LR, et al. BMS-986163, a Negative Allosteric Modulator of GluN2B with Potential Utility in Major Depressive Disorder. ACS Med Chem Lett. 2018 Apr 13;9(5):472-477. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biological Activity
- Description
- IC₅₀ & Target
Chemical Information
Purity & Documentation
References

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BMS-986163

All iGluR Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

BMS-986163 Related Classifications

HY-107774 Related Classifications