DuP 105
Based on 1 Customer Validation
DuP 105 is an orally active oxazolidinone with activity against Gram-positive bacteria. DuP 105 protects staphylococcal and streptococcal infections in mice. DuP 105 can be used for the study of infections caused by gram-positive bacteria.
For research use only. We do not sell to patients.
- Purity: 99.38%
- CAS No.: 96800-41-8
- Formula: C13H16N2O4S
- Molecular Weight:296.34
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Anti-Infection Compound Library
HY-L002
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Antibacterial Compound Library
HY-L049
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Orally Active Compound Library
HY-L061
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Heterocyclic Compound Library
HY-L138
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Bioactive Compound Library Max
HY-L181
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MCE Bioactive Compound Library
HY-L001V
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Bioactive Compound Library
HY-L001
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High-Throughput Bioactive Compound Library
HY-L205
Biological Activity
DuP 105 (4-16 μg/mL) inhibits the growth of all tested clinical isolates of staphylococci (including Staphylococcus aureus, Staphylococcus epidermidis, Staphylococcus haemolyticus, Staphylococcus hominis), streptococci (Lancefield groups A, B, D including Streptococcus faecalis ) and Bacteroides fragilis[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Staphylococcus aureus 1A (2×107 CFU/mouse, i.v.) was injected in kidneys of CF-1 female mice (20±2 g)[1]
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Dosage:100 mg/kg
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Administration:s.c. or p.o., twice daily for 4 days
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Result:Reduced Staphylococcus aureus 1A load in kidneys of CF-1 female mice.
Chemical Information
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CAS No. 96800-41-8
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Appearance Solid
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Molecular Weight 296.34
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Formula C13H16N2O4S
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Color White to off-white
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SMILES
CC(NC[C@H]1CN(C2=CC=C(S(C)=O)C=C2)C(O1)=O)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 125 mg/mL (421.81 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (272 KB)
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SDS (254 KB)
- English - EN (254 KB)
- Français - FR (254 KB)
- Deutsch - DE (254 KB)
- Norwegian - NO (254 KB)
- Español - ES (254 KB)
- Swedish - SV (254 KB)
- Italian - IT (254 KB)
- Korean - KR (254 KB)
- Portuguese - PT (254 KB)
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Handling Instructions (2659 KB)
References
[1]. Slee AM, et al. Oxazolidinones, a new class of synthetic antibacterial agents: in vitro and in vivo activities of DuP 105 and DuP 721. Antimicrob Agents Chemother. 1987 Nov;31(11):1791-7. [Content Brief]
[2]. Barry AL, et al. In vitro evaluation of DuP 105 and DuP 721, two new oxazolidinone antimicrobial agents. Antimicrob Agents Chemother. 1988 Jan;32(1):150-2. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.3745 mL | 16.8725 mL | 33.7450 mL | 84.3626 mL |
| 5 mM | 0.6749 mL | 3.3745 mL | 6.7490 mL | 16.8725 mL | |
| 10 mM | 0.3375 mL | 1.6873 mL | 3.3745 mL | 8.4363 mL | |
| 15 mM | 0.2250 mL | 1.1248 mL | 2.2497 mL | 5.6242 mL | |
| 20 mM | 0.1687 mL | 0.8436 mL | 1.6873 mL | 4.2181 mL | |
| 25 mM | 0.1350 mL | 0.6749 mL | 1.3498 mL | 3.3745 mL | |
| 30 mM | 0.1125 mL | 0.5624 mL | 1.1248 mL | 2.8121 mL | |
| 40 mM | 0.0844 mL | 0.4218 mL | 0.8436 mL | 2.1091 mL | |
| 50 mM | 0.0675 mL | 0.3375 mL | 0.6749 mL | 1.6873 mL | |
| 60 mM | 0.0562 mL | 0.2812 mL | 0.5624 mL | 1.4060 mL | |
| 80 mM | 0.0422 mL | 0.2109 mL | 0.4218 mL | 1.0545 mL | |
| 100 mM | 0.0337 mL | 0.1687 mL | 0.3375 mL | 0.8436 mL |
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