Evatanepag (Synonyms: CP-533536 free acid)

Name: Evatanepag
Brand: MedChemExpress
SKU: HY-14839
Rating: 5.0 (2 reviews)

Cat. No.: HY-14839 Pureza: 98.58%: Ficha de datos
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Evatanepag (CP-533536) is a non-prostanoid, potent and selective EP₂ receptor agonist. Evatanepag can induce local bone formation in vivo. Evatanepag can be used in the research of fractures, bone defects, asthma.

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Evatanepag Estructura química

No. CAS : 223488-57-1

Tamaño	Stock	Cantidad

Muestra gratis (0.1 - 0.2 mg)	Solicite ahora
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	En stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	En stock	Estimated Time of Arrival: December 31
Solid
5 mg	En stock	Estimated Time of Arrival: December 31
10 mg	En stock	Estimated Time of Arrival: December 31
25 mg	En stock	Estimated Time of Arrival: December 31
50 mg	En stock	Estimated Time of Arrival: December 31
100 mg	En stock	Estimated Time of Arrival: December 31
200 mg	Obtener un presupuesto
500 mg	Obtener un presupuesto

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Revisión del cliente

Based on 2 publication(s) in Google Scholar

Other Forms of Evatanepag:

Evatanepag sodium Obtener un presupuesto

2 Publications Citing Use of MCE Evatanepag

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Ver todas las isoformas

DP EP FP IP TXA₂/TP TXB₂

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Descripciòn

IC₅₀ & Target^[1]

EP2

Cellular Effect

Cell Line	Type	Value	Description	References
HEK293	EC₅₀	0.3 nM Compound: 7f, CP-533536	Agonist activity against rat EP2 receptor expressed in HEK293 cells assessed as stimulation of cAMP release Agonist activity against rat EP2 receptor expressed in HEK293 cells assessed as stimulation of cAMP release	[PMID: 19250823]
HEK293	IC₅₀	>3200 nM Compound: 7f, CP-533536	Inhibition of rat EP4 receptor expressed in HEK293 cells Inhibition of rat EP4 receptor expressed in HEK293 cells	[PMID: 19250823]
HEK293	IC₅₀	50 nM Compound: 7f, CP-533536	Inhibition of rat EP2 receptor expressed in HEK293 cells Inhibition of rat EP2 receptor expressed in HEK293 cells	[PMID: 19250823]

In Vitro

Evatanepag (10 nM, 30 min) inhibits hFcεRI-induced mast cells degranulation in a dose-dependent manner^[2].
Evatanepag (0.1 nM-10 μM, 12 min) results in an equivalent increase in intracellular cAMP in HEK-293 cells, with an IC₅₀ of 50 nM^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Evatanepag (0.3-3.0 mg/kg, directly injected into the marrow cavity of the tibia) promotes bone formation in rats^[1].
Evatanepag (0.3, 3.0 mg/kg, intranasal administration, from day1 to day4) reduces HDM aeroallergen-induced increased RL response to methacholine in mice^[2].
Evatanepag (1 mg/kg, intravenous injection) demonstrates high i.v. clearance (Cl: 56 mL/min/kg) and a short half-life (t_1/2: 0.33 h)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Rats^[1]
Dosage:	0.3, 1.0, 3.0 mg/kg
Administration:	Directly injected into the marrow cavity of the tibia
Result:	Dose-dependently increased in bone area, bone mineral content, bone mineral density.

Animal Model:	HDM (house dust mite)-sensitized BALB/c mice^[2]
Dosage:	0.3 mg/kg, 3 mg/kg
Administration:	Intranasal administration, from day1 to day4
Result:	Prevented aeroallergen-driven increased RL (lung resistance) at 0.3 mg/kg. Prevented the enhanced MC activity by approximately 48% at 3 mg/kg.

Peso molecular

468.57

Fòrmula

C₂₅H₂₈N₂O₅S

No. CAS

223488-57-1

Appearance

Solid

Color

White to off-white

SMILES

CC(C)(C)C(C=C1)=CC=C1CN(S(C2=CN=CC=C2)(=O)=O)CC3=CC(OCC(O)=O)=CC=C3

Envío

Room temperature in continental US; may vary elsewhere.

Almacenamiento

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	2 years
	-20°C	1 year

Solvente y solubilidad

In Vitro:

DMSO : ≥ 32 mg/mL (68.29 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.1342 mL	10.6708 mL	21.3415 mL
5 mM	0.4268 mL	2.1342 mL	4.2683 mL
10 mM	0.2134 mL	1.0671 mL	2.1342 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Calculadora de molaridad
Calculadora de dilución

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Pureza y Documentación

Purity: 98.58%

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Ficha de datos (281 KB) SDS (396 KB)

COA (257 KB) HNMR (155 KB) LCMS (339 KB)

Instrucciones de manejo (2659 KB)

Referencias

[1]. Cameron KO, et al. Discovery of CP-533536: an EP2 receptor selective prostaglandin E2 (PGE2) agonist that induces local bone formation. Bioorg Med Chem Lett. 2009 Apr 1;19(7):2075-8. [Content Brief]

[2]. Judith Plaza, et al. In Vitro and In Vivo Validation of EP2-Receptor Agonism to Selectively Achieve Inhibition of Mast Cell Activity. Allergy Asthma Immunol Res. 2020 Jul;12(4):712-728. [Content Brief]

[3]. V M Paralkar, et al. An EP2 receptor-selective prostaglandin E2 agonist induces bone healing. Proc Natl Acad Sci U S A. 2003 May 27;100(11):6736-40. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.1342 mL	10.6708 mL	21.3415 mL	53.3538 mL
	5 mM	0.4268 mL	2.1342 mL	4.2683 mL	10.6708 mL
	10 mM	0.2134 mL	1.0671 mL	2.1342 mL	5.3354 mL
	15 mM	0.1423 mL	0.7114 mL	1.4228 mL	3.5569 mL
	20 mM	0.1067 mL	0.5335 mL	1.0671 mL	2.6677 mL
	25 mM	0.0854 mL	0.4268 mL	0.8537 mL	2.1342 mL
	30 mM	0.0711 mL	0.3557 mL	0.7114 mL	1.7785 mL
	40 mM	0.0534 mL	0.2668 mL	0.5335 mL	1.3338 mL
	50 mM	0.0427 mL	0.2134 mL	0.4268 mL	1.0671 mL
	60 mM	0.0356 mL	0.1778 mL	0.3557 mL	0.8892 mL

Evatanepag Related Classifications

Inflammation/Immunology Endocrinology Cardiovascular Disease

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Evatanepag223488-57-1CP-533536CP533536CP 533536Prostaglandin ReceptorFracture healingboneHDMallergymast cellasthmainflammationInhibitorinhibitorinhibit

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Evatanepag (Synonyms: CP-533536 free acid)

Revisión del cliente

Other Forms of Evatanepag:

Evatanepag Related Antibodies

2 Publications Citing Use of MCE Evatanepag

Recomendaciones destacadas

•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

Ver todos los productos específicos de isoformas Prostaglandin Receptor:

Actividad biológica

Pureza y Documentación

Referencias

Revisión del cliente

Evatanepag Related Antibodies

Calculadora de molaridad

Calculadora de dilución

Complete Stock Solution Preparation Table

Evatanepag Related Classifications

Keywords:

Productos vistos recientemente:

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SAFETY DATA SHEET (SDS)

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