1. GPCR/G Protein
    Neuronal Signaling
  2. 5-HT Receptor
  3. LY 344864 hydrochloride

LY 344864 hydrochloride 

Cat. No.: HY-13788B
Handling Instructions

LY 344864 hydrochloride is a selective 5-HT1F agonist with a Ki of 6 nM.

For research use only. We do not sell to patients.

LY 344864 hydrochloride Chemical Structure

LY 344864 hydrochloride Chemical Structure

CAS No. : 1217756-94-9

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Description

LY 344864 hydrochloride is a selective 5-HT1F agonist with a Ki of 6 nM.

IC50 & Target[1]

5-HT1F Receptor

6 nM (Ki)

In Vitro

LY344864 is a selective receptor agonist with an affinity of 6 nM (Ki) at the recently cloned 5-HT1F receptor. It possesses little affinity for the 56 other serotonergic and non-serotonergic neuronal binding sites examined. When examined for its ability to inhibit forskolininduced cyclic AMP accumulation in cells stably transfected with human 5-HT1F receptors, LY344864 is shown to be a full agonist producing an effect similar in magnitude to serotonin itself[1].

In Vivo

After an intravenous dose of 1 mg/kg, rat plasma LY344864 levels decline with time whereas brain cortex levels remaine relatively constant for the first 6 hours after injection. Oral and intravenous LY344864 administration potently inhibit dural protein extravasation caused by electrical stimulation of the trigeminal ganglion in rats[1]. Co-injection of LY 344864 and systemically ineffective doses of METH significantly decreases preference scores and the rewarding properties of METH during the reinstatement phase. In addition, administration of LY 344864 has no effect on the acquisition of CPP in rats[2].

Molecular Weight

387.88

Formula

C₂₁H₂₃ClFN₃O

CAS No.

1217756-94-9

SMILES

O=C(NC1=CC2=C(NC3=C2C[[email protected]](N(C)C)CC3)C=C1)C4=CC=C(F)C=C4.[H]Cl

Shipping

Room temperature in continental US; may vary elsewhere

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
Animal Administration
[2]

Rats[2]

Male albino Wistar rats are divided into different groups. Rats in the experimental LY344864 and sham groups receive LY 344864 (1 or 2 μg/5 μL; intracerebroventricular [i.c.v.]), vehicle (5 μl/rat i.c.v.), or saline (5 μl/rat i.c.v.) during the acquisition phase[2]

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

References
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LY 344864 hydrochloride
Cat. No.:
HY-13788B
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