LY 344864 hydrochloride
Based on 2 publication(s) in Google Scholar
LY 344864 hydrochloride is a selective, orally active 5-HT1F receptor agonist with a Ki of 6 nM. LY 344864 hydrochloride is a full agonist producing an effect similar in magnitude to serotonin itself. LY 344864 hydrochloride can cross the blood brain barrier to some extent.
For research use only. We do not sell to patients.
- CAS No.: 1217756-94-9
- Formula: C21H23ClFN3O
- Molecular Weight:387.88
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
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- References
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Publications Citing Use of MedChemExpress (MCE) LY 344864 hydrochloride
MoreAll 5-HT Receptor Isoforms
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Biological Activity
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human 5-HT1F Receptor 0.006 μM (Ki) |
5-HT1F Receptor |
human 5-HT1A Receptor 0.530 μM (Ki) |
human 5-HT1B Receptor 0.549 μM (Ki) |
human 5-HT1D Receptor 0.575 μM (Ki) |
human 5-HT1E Receptor 1.415 μM (Ki) |
human 5-HT2B Receptor 1.695 μM (Ki) |
Human 5-HT2C Receptor 3.499 μM (Ki) |
Human 5-HT3A Receptor 3.935 μM (Ki) |
Human 5-HT7 Receptor 4.851 μM (Ki) |
rat α2-adrenergic receptor 3.69 μM (Ki) |
rat α1-adrenergic receptor 5.06 μM (Ki) |
LY 344864 binds to human 5-HT1F, 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, 5-HT3A, 5-HT2B, 5-HT2C, 5-HT7, rat α1-adrenergic, rat α2-adrenergic receptors with Kis of 0.006, 0.530, 0.549, 0.575, 1.415, 3.935, 1.695, 3.499, 4.851, 5.06 and 3.69 μM, respectively[1].
LY 344864 is a inducer of mitochondrial biogenesis[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
LY 344864 (1 mg/kg; i.v.; once) can cross the blood brain barrier to some extent in rats[1].
LY 344864 (2 mg/kg; i.p.; daily for 14 days) attenuates dopaminergic neuron loss and improved behavioral endpoints in a Parkinson’s disease mouse model[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Male Wistar rats, migraine pain model[1]
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Dosage:1-10 ng/kg (oral), 0.3-2 ng/kg (intravenous)
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Administration:Oral, 75 minutes before trigeminal stimulation or intravenous, 10 minutes before trigeminal stimulation
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Result:When given intravenously 10 minutes before stimulation, inhibited inflammation with an ID50 (median infective dose) of 0.6 ng/kg. When administered orally 75 minutes before trigeminal stimulation, an ID50 of 1.2 ng/kg was obtained.
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Animal Model:Male C57BL/6 mice, Parkinson’s disease model[2]
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Dosage:2 mg/kg
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Administration:Intraperitoneal injection, daily for 14d beginning 7d post-lesion
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Result:Attenuated TH-ir loss in the striatum and substantia nigra compared to vehicle-treated lesioned animals, also increased locomotor activity in 6-hydroxydopamine lesioned mice, while vehicle treatment had no effect.
Chemical Information
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CAS No. 1217756-94-9
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Molecular Weight 387.88
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Formula C21H23ClFN3O
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SMILES
O=C(NC1=CC2=C(NC3=C2C[C@H](N(C)C)CC3)C=C1)C4=CC=C(F)C=C4.[H]Cl
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (2)
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Journal Impact Factor
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Most Recent
Purity & Documentation
References
[1]. Phebus LA, et al. Characterization of LY344864 as a pharmacological tool to study 5-HT1F receptors: binding affinities, brain penetration and activity in the neurogenic dural inflammation model of migraine. Life Sci. 1997;61(21):2117-26. [Content Brief]
[2]. Scholpa NE, et al. 5-HT1F receptor-mediated mitochondrial biogenesis for the treatment of Parkinson's disease. Br J Pharmacol. 2018 Jan;175(2):348-358. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
LY 344864 hydrochloride Related Classifications
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