1. GPCR/G Protein
    Neuronal Signaling
  2. 5-HT Receptor

LY 344864 hydrochloride 

Cat. No.: HY-13788B
Handling Instructions

LY 344864 hydrochloride is a selective 5-HT1F agonist with a Ki of 6 nM.

For research use only. We do not sell to patients.

LY 344864 hydrochloride Chemical Structure

LY 344864 hydrochloride Chemical Structure

CAS No. : 1217756-94-9

Size Stock
250 mg Get quote
500 mg Get quote

* Please select Quantity before adding items.

Other Forms of LY 344864 hydrochloride:

  • Biological Activity

  • Protocol

  • Technical Information

  • Purity & Documentation

  • References

Description

LY 344864 hydrochloride is a selective 5-HT1F agonist with a Ki of 6 nM.

IC50 & Target[1]

5-HT1F Receptor

6 nM (Ki)

In Vitro

LY344864 is a selective receptor agonist with an affinity of 6 nM (Ki) at the recently cloned 5-HT1F receptor. It possesses little affinity for the 56 other serotonergic and non-serotonergic neuronal binding sites examined. When examined for its ability to inhibit forskolininduced cyclic AMP accumulation in cells stably transfected with human 5-HT1F receptors, LY344864 is shown to be a full agonist producing an effect similar in magnitude to serotonin itself[1].

In Vivo

After an intravenous dose of 1 mg/kg, rat plasma LY344864 levels decline with time whereas brain cortex levels remaine relatively constant for the first 6 hours after injection. Oral and intravenous LY344864 administration potently inhibit dural protein extravasation caused by electrical stimulation of the trigeminal ganglion in rats[1]. Co-injection of LY 344864 and systemically ineffective doses of METH significantly decreases preference scores and the rewarding properties of METH during the reinstatement phase. In addition, administration of LY 344864 has no effect on the acquisition of CPP in rats[2].

Solvent & Solubility
In Vitro: 

10 mM in DMSO

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.5781 mL 12.8906 mL 25.7812 mL
5 mM 0.5156 mL 2.5781 mL 5.1562 mL
10 mM 0.2578 mL 1.2891 mL 2.5781 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Animal Administration
[2]

Rats[2]

Male albino Wistar rats are divided into different groups. Rats in the experimental LY344864 and sham groups receive LY 344864 (1 or 2 μg/5 μL; intracerebroventricular [i.c.v.]), vehicle (5 μl/rat i.c.v.), or saline (5 μl/rat i.c.v.) during the acquisition phase[2]

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

References
Molecular Weight

387.88

Formula

C₂₁H₂₃ClFN₃O

CAS No.

1217756-94-9

SMILES

O=C(NC1=CC2=C(NC3=C2C[[email protected]](N(C)C)CC3)C=C1)C4=CC=C(F)C=C4.[H]Cl

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Shipping

Room temperature in continental US; may vary elsewhere

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Inquiry Online

Your information is safe with us. * Required Fields.

Product name

 

Salutation

Applicant name *

 

Email address *

Phone number *

 

Organization name *

Country or Region *

 

Requested quantity *

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
LY 344864 hydrochloride
Cat. No.:
HY-13788B
Quantity:

LY 344864 hydrochloride

Cat. No.: HY-13788B