Lurasidone Metabolite 14283 hydrochloride

製品番号: HY-G0001A 純度: 99.06%: Data Sheet SDS COA 取扱説明書
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Lurasidone Metabolite 14283 hydrochloride is a major active metabolite of Lurasidone. Lurasidone is a FDA approved agent for the treatment of schizophrenia.

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Lurasidone Metabolite 14283 hydrochloride 構造式

CAS 番号 : 186204-32-0

容量	価格（税別）	在庫状況	数量
1 mg	$316	在庫あり	Estimated Time of Arrival: December 31
5 mg	$790	在庫あり	Estimated Time of Arrival: December 31
10 mg		お問い合わせ
50 mg		お問い合わせ

or バルクお問い合わせ

* アイテムを追加する前、数量をご選択ください

This product is a controlled substance and not for sale in your territory.

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Other Forms of Lurasidone Metabolite 14283 hydrochloride:

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製品説明

Lurasidone Metabolite 14283 hydrochloride is a major active metabolite of Lurasidone. Lurasidone is a FDA approved agent for the treatment of schizophrenia.

分子量

545.14

分子式

C₂₈H₃₇ClN₄O₃S

CAS 番号

186204-32-0

Appearance

Solid

Color

White to off-white

SMILES

O=C([C@]([C@@H]1C[C@@H](O)[C@H]2C1)([H])[C@]2([H])C3=O)N3C[C@H]4[C@H](CN(CC5)CCN5C6=NSC7=C6C=CC=C7)CCCC4.Cl[H]

輸送条件

Room temperature in continental US; may vary elsewhere.

保管条件

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

溶剤 & 溶解度

体外:

Ethanol : 100 mg/mL (183.44 mM; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.8344 mL	9.1720 mL	18.3439 mL
5 mM	0.3669 mL	1.8344 mL	3.6688 mL
10 mM	0.1834 mL	0.9172 mL	1.8344 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

一般には略語で表示されます：C₁V₁ = C₂V₂

濃度 _（開始）

体積 _（開始）

濃度 _（終了）

体積 _（終了）

体内:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% EtOH 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (4.59 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL EtOH stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Protocol 2

Add each solvent one by one: 10% EtOH 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (4.59 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL EtOH stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Protocol 3

Add each solvent one by one: 10% EtOH 90% Corn Oil
Solubility: ≥ 2.5 mg/mL (4.59 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Taking 1 mL working solution as an example, add 100 μL EtOH stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

純度とドキュメンテーション

純度: 99.06%

Select Batch:

データシート (274 KB) SDS (251 KB)

COA (255 KB) HNMR (163 KB) RP-HPLC (204 KB) LCMS (295 KB)

取扱説明書 (2659 KB)

参考文献

[1]. Sanford M, et al. Lurasidone : in the treatment of schizophrenia. CNS Drugs. 2013 Jan;27(1):67-80. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

Ethanol	1 mM	1.8344 mL	9.1720 mL	18.3439 mL	45.8598 mL
	5 mM	0.3669 mL	1.8344 mL	3.6688 mL	9.1720 mL
	10 mM	0.1834 mL	0.9172 mL	1.8344 mL	4.5860 mL
	15 mM	0.1223 mL	0.6115 mL	1.2229 mL	3.0573 mL
	20 mM	0.0917 mL	0.4586 mL	0.9172 mL	2.2930 mL
	25 mM	0.0734 mL	0.3669 mL	0.7338 mL	1.8344 mL
	30 mM	0.0611 mL	0.3057 mL	0.6115 mL	1.5287 mL
	40 mM	0.0459 mL	0.2293 mL	0.4586 mL	1.1465 mL
	50 mM	0.0367 mL	0.1834 mL	0.3669 mL	0.9172 mL
	60 mM	0.0306 mL	0.1529 mL	0.3057 mL	0.7643 mL
	80 mM	0.0229 mL	0.1146 mL	0.2293 mL	0.5732 mL
	100 mM	0.0183 mL	0.0917 mL	0.1834 mL	0.4586 mL