Men 10376
Based on 1 publication(s) in Google Scholar
Men 10376 is a selective tachykinin NK-2 receptor antagonist, with a Ki of 4.4 μM for rat small intestine NK-2 receptor.
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研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 135306-85-3
- 分子式: C57H68N12O10
- 分子量:1081.22
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
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MedChemExpress（MCE）の使用を引用している文献 Men 10376
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生物活性
製品説明
IC50 & Target
Ki: 4.4 μM (NK-2 receptor, rat small intestine)[1]
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| CHO | EC50 |
78.1 nM
Compound: MEN-10376
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Displacement of [3H]SR48968 from human recombinant NK2 receptor expressed in CHO cells
Displacement of [3H]SR48968 from human recombinant NK2 receptor expressed in CHO cells
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[PMID: 16562853] |
体外実験
Men 10376 is a selective tachykinin NK-2 receptor, with a Ki of 4.4 μM, and shows low selectivity for NK-1 and NK-3 receptors (Ki, >10 μM)[1]. Men 10376 shows pA2s of 5.66 and 8.08 for NK-1 (guinea-pig ileum) and NK-2 receptors (endothelium-deprived rabbit pulmonary artery). Men 10376 shows no effect on NK-3 receptor (Ki, >10 μM)[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. .
体内実験
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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CAS 番号 135306-85-3
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分子量 1081.22
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分子式 C57H68N12O10
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別名
Neurokinin-2 receptor antagonist
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配列
Asp-Tyr-{d-Trp}-Val-{d-Trp}-{d-Trp}-Lys-NH2
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シーケンスの短縮
DY-{d-Trp}-V-{d-Trp}{d-Trp}-K-NH2
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (1)
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Journal Impact Factor
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Most Recent
純度とドキュメンテーション
参考文献
[1]. Quartara L, et al. N-terminal truncated analogs of men 10376 as tachykinin NK-2 receptor antagonists. Life Sci. 1992;51(25):1929-36. [Content Brief]
[2]. Maggi CA, et al. In vivo evidence for tachykininergic transmission using a new NK-2 receptor-selective antagonist, MEN 10,376. J Pharmacol Exp Ther. 1991 Jun;257(3):1172-8. [Content Brief]
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Men 10376 関連分類
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