1. Cell Cycle/DNA Damage
    Anti-infection
  2. DNA/RNA Synthesis
    SARS-CoV
  3. Remdesivir

Remdesivir (Synonyms: GS-5734)

製品番号: HY-104077 純度: 99.74%
取扱説明書

Remdesivir (GS-5734), a nucleoside analogue with effective antiviral activity, has EC50s of 74 nM for SARS-CoV and MERS-CoV in HAE cells, and 30 nM for murine hepatitis virus in delayed brain tumor cells. Remdesivir is highly effective in the control of SARS-CoV-2 (COVID-19) infection in vitro.

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Remdesivir 構造式

Remdesivir 構造式

CAS 番号 : 1809249-37-3

容量 価格(税別) 在庫状況 数量
10 mM * 1 mL in DMSO USD 729 在庫あり
Estimated Time of Arrival: December 31
1 mg USD 220 在庫あり
Estimated Time of Arrival: December 31
5 mg USD 550 在庫あり
Estimated Time of Arrival: December 31
10 mg USD 850 在庫あり
Estimated Time of Arrival: December 31
50 mg   お問い合わせ  
100 mg   お問い合わせ  

* アイテムを追加する前、数量をご選択ください

カスタマーレビュー

Based on 26 publication(s) in Google Scholar

Other Forms of Remdesivir:

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製品説明

Remdesivir (GS-5734), a nucleoside analogue with effective antiviral activity, has EC50s of 74 nM for SARS-CoV and MERS-CoV in HAE cells, and 30 nM for murine hepatitis virus in delayed brain tumor cells. Remdesivir is highly effective in the control of SARS-CoV-2 (COVID-19) infection in vitro[1][2].

IC50 & Target

EC50: 30 nM (murine hepatitis virus, delayed brain tumor cell), 74 nM (SARS-CoV, HAE cell), 74 nM (MERS-CoV, HAE cell)[1]

体外実験

Remdesivir (GS-5734) is a potent antiviral agent. Remdesivir inhibits murine hepatitis virus (MHV) with an EC50 of 30 nM, and blocks SARS-CoV and MERS-CoV in HAE cells with EC50s of both 74 nM in HAE cells after treatment for 24 h[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

臨床実験
分子量

602.58

分子式

C₂₇H₃₅N₆O₈P

CAS 番号

1809249-37-3

SMILES

C[[email protected]](N[[email protected]@](OC1=CC=CC=C1)(OC[[email protected]]2O[[email protected]@](C#N)(C3=CC=C4C(N)=NC=NN43)[[email protected]](O)[[email protected]@H]2O)=O)C(OCC(CC)CC)=O

輸送条件

Room temperature in continental US; may vary elsewhere.

保管条件
Powder -20°C 3 years
In solvent -80°C 6 months
  -20°C 1 month
溶剤 & 溶解度
体外: 

DMSO : ≥ 100 mg/mL (165.95 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.6595 mL 8.2977 mL 16.5953 mL
5 mM 0.3319 mL 1.6595 mL 3.3191 mL
10 mM 0.1660 mL 0.8298 mL 1.6595 mL
*Please refer to the solubility information to select the appropriate solvent.
体内:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.17 mg/mL (3.60 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.17 mg/mL (3.60 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.17 mg/mL (3.60 mM); Clear solution

*All of the co-solvents are provided by MCE.
参考文献

純度: 99.74%

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The molarity calculator equation

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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× = ×
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Keywords:

RemdesivirGS-5734GS5734GS 5734DNA/RNA SynthesisSARS-CoVSARS coronavirusantiviralMERS-CoV2019-nCoVCOVID-19infectionInhibitorinhibitorinhibit

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製品名:
Remdesivir
製品番号:
HY-104077
数量:
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