Infection

Enniatin A-¹³C₃₆ is the ¹³C-labeled Enniatin A (HY-N6702). Enniatin A is a Fusarium mycotoxin. Enniatin A inhibits acyl-CoA: cholesterol acyltransferase (ACAT) activity with an IC₅₀ of 22 μM in an enzyme assay using rat liver microsomes.

1-Hydroxyauramycin B is an anthracycline antibiotic. 1-Hydroxyauramycin B has anti-Gram-positive bacteria and anti-tumor cell activity.

L 756423 is a potent HIV protease inhibitor. L 756423 has the potential for the research of HIV infection.

Zika virus-IN-1 (Compd 2) is a Zika virus inhibitor, with an EC₅₀ of 1.56 μM .

Insecticidal agent 31 is an insecticide targeting the γ-aminobutyric acid receptor (GABAR). Insecticidal agent 31 exhibits insecticidal activity against Plutella xylostella, Spodoptera frugiperda and Spodoptera exigua. Insecticidal agent 31 can serve as a lead compound for the design and synthesis of novel isoxazole-based insecticides.

l-Primaquine is an antimalarial drug with activity in inhibiting and preventing malaria. l-Primaquine is also used to inhibit Pneumocystis jiroveci pneumonia.

Metaldehyde (Standard) is the analytical standard of Metaldehyde. This product is intended for research and analytical applications. Metaldehyde is a commonly used pesticide for mollusks such as slugs and snails.

Antitrypanosomal agent 32 is a antitrypanosomal agent with nanomolar potency against multiple Trypanosoma cruzi strains, including CL-Brener, Y, Dm28c-Luc and Tulahuen. Antitrypanosomal agent 32 sustains inhibition of parasite growth after washing and reduces parasitemia levels in BALB/c mice. Antitrypanosomal agent 32 can be used for the research of trypanosome infection.

Thioridazine (Standard) is the analytical standard of Thioridazine. This product is intended for research and analytical applications. Thioridazine, an antagonist of the dopamine receptor D2 family proteins, exhibits potent anti-psychotic and anti-anxiety activities. Thioridazine is also a potent inhibitor of PI3K-Akt-mTOR signaling pathways with anti-angiogenic effect. Thioridazine shows antiproliferative and apoptosis induction effects in various types of cancer cells, with specificity on targeting cancer stem cells (CSCs).

TCMDC-125431 is a novel disruptor of the malaria parasite calcium dynamics but minimally inhibits heme crystallization.

20(R)-Ginsenoside Rh2 (Standard) is the analytical standard of 20(R)-Ginsenoside Rh2. This product is intended for research and analytical applications. 20(R)-Ginsenoside Rh2 is an orally active protopanaxadiol-type saponin with multiple biological activities. 20(R)-Ginsenoside Rh2 exerts a significant inhibitory effect on non-small cell lung cancer and liver cancer by inducing cell cycle arrest and promoting apoptosis. 20(R)-Ginsenoside Rh2 exerts anti-γ-herpesvirus effects by inhibiting viral DNA replication. 20(R)-Ginsenoside Rh2 inhibits inflammatory mediators by reducing the levels of NO, PGE2, and ROS; it can delay skin photoaging by reducing ROS and inhibiting MMP-9/2 activity. 20(R)-Ginsenoside Rh2 accelerates the recovery after muscle injury by activating the Akt1/PKB signaling pathway. 20(R)-Ginsenoside Rh2 can inhibit osteoclast formation and exert an anti-osteoporosis effect.

Chitin synthase inhibitor 13 (compound 12g) is a non-competitive inhibitor of chitin synthase, with an IC₅₀ of 106.7 μM. Chitin synthase inhibitor 13 exhibits a broad-spectrum of antifungal activity.

Enpyracymid is a succinate dehydrogenase inhibitor (SDHI) fungicide with fungicidal activity against fungal. It can be used in studies related to Fusarium head blight (FHB).

(Rac)-Tenofovir ((Rac)-GS 1278; (Rac)-PMPA) is an isomer of Tenofovir (HY-13910). Tenofovir is a nucleotide reverse transcriptase inhibitor to treat HIV and chronic Hepatitis B (HBV).

Haemanthamine hydrochloride is a crinine-type alkaloid isolated from the Amaryllidaceae plants with potent anticancer activity. Haemanthamine hydrochloride targets ribosomal that inhibits protein biosynthesis during the elongation stage of translation. Haemanthamine hydrochloride has pro-apoptotic, antioxidant, antiviral, antimalarial and anticonvulsant activities.

Leucomycin tartrate (Kitasamycin tartrate) is a potent 16-membered macrolideantibiotic.

cis-3-Hexenyl benzoate is a volatile organic compound with a grassy aroma, widely used in the fragrance and cosmetic industries. It exhibits weak antifungal activity. cis-3-Hexenyl benzoate shows no significant risks in genotoxicity, reproductive toxicity, or environmental toxicity, and its skin sensitization potential is controllable within defined concentration limits.

SARS-CoV-2 Mpro-IN-50 (Compound 30) is a noncovalent SARS-CoV-2 Mpro inhibitor with an IC₅₀ of 14  nM. SARS-CoV-2 Mpro-IN-50 is also a pan-CoV Mpro inhibitor with IC₅₀ s of 20-190 nM for SARS-CoV-1 Mpro, 229E Mpro, HKU1 Mpro, MERS Mpro, NL63 Mpro and OC43 Mpro. SARS-CoV-2 Mpro-IN-50 has significant antiviral activity against the SARS-CoV-2 omicron variant (EC₅₀ : 22  nM). SARS-CoV-2 Mpro-IN-50 can be used for coronavirus infections research.

Arcopilin A (compound Arcopilin A(1))is an antibacterial agent. Arcopilin A has weak inhibitory effects on fungal pathogens and Gram-positive bacteria, with IC₅₀ values of 8.9 μg/mL and 14 μg/mL for cells KB-3-1 and L929, but it can effectively destroy preformed biofilms of Staphylococcus aureus. Arcopilin A can enhance the activities of gentamicin (GM; HY-K1050) and vancomycin (Vac; HY-B0671) by 115 and 31 times, respectively.

Calpain inhibitor V (Mu-Val-HPh-FMK) is a cell-permeable and irreversible inhibitor of calpain that has anti-chlamydial activity.