Infection

Cyclothiazomycin selectively inhibits renin activity and does not inhibit pepsin, aspartic acid, serine, mercaptan protease and metalloproteinases. Cyclothiazomycin has weak antifungal activity.

Stevaladil, an vasodilator, is a amebicide agent.

Glycine ethyl ester-¹³C hydrochloride is a ¹³C-labeled Glycine ethyl ester hydrochloride (HY-76204). Glycine ethyl ester monohydrochloride is a Glycine (HY-Y0966) derivative.

Quinocetone (Standard) is the analytical standard of Quinocetone (HY-123581). This product is used for research and analytical purposes. Quinocetone is an orally active animal feed additive used to increase the meat production of livestock and poultry. Quinocetone exhibits antibacterial activity against a variety of pathogenic microorganisms. Quinocetone exhibits tissue-specific (liver, lymphocyte) toxicity. Quinocetone induces autophagy in cells through the ATF6/DAPK1 pathway. Quinocetone activates the NF-κB and iNOS pathways, leading to cell apoptosis, hepatocyte vacuolar degeneration and fibrosis. Quinocetone can inhibit Nrf2/HO-1 and induce the generation of reactive oxygen species (ROS), leading to oxidative stress and DNA damage.

Furalaxyl (Standard) is the analytical standard of Furalaxyl. This product is intended for research and analytical applications. Furalaxyl (CGA 38140) is a potent fungicide. Furalaxyl is highly selective to fungi of the order of the Peronosporales.

HCV-IN-50 (Compound 2) is a competitive and selective HCV NS5B RNA-dependent RNA polymerase inhibitor with an IC₅₀ of 0.3  μM for NS5B △C21 enzyme over △C55 enzyme. HCV-IN-50 has an antiviral activity and efficiently blocks replication of HCV subgenomic replicons especially mutant replicons.

DL-Methionine (Standard) is the analytical standard of DL-Methionine. This product is intended for research and analytical applications. DL-Methionine is an essential amino acid containing sulfur with oxidative stress defense effects. DL-Methionine can be used for animal natural feed. DL-Methionine also kills H. rostochiensis on potato plants.

Globotriaosylceramide porcine RBC is a trihexosylceramide (Gb3) in porcine erythrocytes. Globotriaosylceramide porcine RBC is a natural resistance factor against HIV-1 infection. The synthetase α-galactosyltransferase (A4GALT) of Globotriaosylceramide porcine RBC is associated with HIV-1 resistance.

Antifungal agent 141, a Phenoxazine (HY-34463) derivative, is an antifungal agent. Antifungal agent shows potent antifungal activity in Cryptococcus neoformans and Candida albicans with MIC values of 2 and 4 µg/mL. Antifungal agent 141 can be used for the research of cryptococcal meningitis.

Sulbactam-d₃ (CP45899-d₃) is deuterium labeled Sulbactam. Sulbactam (CP45899) is a competitive, irreversible beta-lactamase inhibitor. Sulbactam shows antimicrobial activity against multidrug-resistant (MDR) acinetobacter calcoaceticus--Acinetobacter baumannii (Acb) complex.

Cefetamet pivoxyl (Standard) (Ro 15-8075 (free base) (Standard)) is the analytical standard of Cefetamet pivoxyl (HY-B1894). This product is intended for research and analytical applications. Cefetamet pivoxyl (Ro 15-8075 free base) is an orally active cephalosporin Antibiotic and a prodrug of Cefetamet (HY-A0111). After ingestion, Cefetamet pivoxyl is hydrolyzed by gastrointestinal esterases to form Cefetamet. Cefetamet pivoxyl is primarily active against aerobic Gram-negative bacteria (such as Enterobacteriaceae, Neisseria, Haemophilus) and some Gram-positive bacteria (such as non-enterococcal streptococci). Cefetamet pivoxyl exhibits potent in vivo antibacterial activity against strains of Gram-positive bacteria (S. pyogenes) and Gram-negative bacteria (E. coli, K. pneumoniae, S. marcescens, P. vulgaris, P. mirabilis, H. influenzae).

Glisoprenin A is a cholesterol acyltransferase (ACAT) inhibitor, and it can inhibit the formation of Appressorium on the hydrophobic surface of Magnaporthegrisea.

Iodoantipyrine (Standard) is the analytical standard of Iodoantipyrine. This product is intended for research and analytical applications. Iodoantipyrine (4-Iodoantipyrine) is an iodinated Antipyrine (HY-B0171) with potential antiviral activity. Antipyrine (Phenazone) is an antipyretic and analgesic that also serves as a molecular probe of hepatic oxidative metabolites.

Chitinovorin A is a β-lactam antibiotic with a weak inhibitory activity against Gram-negative bacteria.

Concanamycin G has antifungal, antiviral, immunosuppressive, cytotoxic and other activities, and is a specific inhibitor of V-type ATPase (K_i=0.02 nM), which is an important tool for biochemical research.

EG35 is a nucleotide-binding domain-targeted DnaK inhibitor. EG35 binds to Escherichia coli DnaK and inhibits the ATPase activity stimulated by DnaJ and GrpE.

Bictegravir-d₅ is deuterated labeled Bictegravir (HY-17605). Bictegravir (GS-9883) is a potent inhibitor of HIV-1 integrase with an IC₅₀ of 7.5 nM.

Chrolactomycin is found in the strain of Streptomyces sp. 569N-3. The IC₅₀ of Chrolactomycin for ACHN, A431, McF-7 and T24 cells are 1.2 μM, 1.6 μM, 0.69 μM and 0.45 μM, respectively. Chrolactomycin has only anti-Gram-positive bacteria activity with the MIC of 5.2-10.4 μg/mL.

ACP1-01 is a bacterial ClpP activator with EC₅₀s of 3.4 and 2.6  μM for Neisseria meningitides ClpP (NmClpP) and Escherichia coli ClpP (EcClpP). ACP1-01 noncovalently binds to ClpP C sites and activates the protease. ACP1-01 has antibacterial activity. ACP1-01 can be used for bacterial infections research.

Phaseollinisoflavan, an antifungal isoflavonoid, is a phytoalexin.